Matthew Perry

Senior Lecturer

publications

Journal articles
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Ng CA; Perry MD; Liang W; Smith NJ; Foo B; Shrier A; Lukacs GL; Hill AP; Vandenberg JI, 2020, 'High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants', Heart Rhythm, vol. 17, pp. 492 - 500, http://dx.doi.org/10.1016/j.hrthm.2019.09.020
2020
Lee W; Windley MJ; Perry MD; Vandenberg JI; Hill AP, 2019, 'Protocol-dependent differences in IC50 values measured in human ether-á-go-go–related gene assays occur in a predictable way and can be used to quantify state preference of drug binding', Molecular Pharmacology, vol. 95, pp. 537 - 550, http://dx.doi.org/10.1124/mol.118.115220
2019
Perry MD; Ng C-A; Mangala MM; Ng TYM; Hines AD; Liang W; Xu MJO; Hill AP; Vandenberg JI, 2019, 'Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization.', Cardiovasc Res, http://dx.doi.org/10.1093/cvr/cvz247
2019
Vandenberg JI; Perry MD; Hill AP, 2017, 'Recent advances in understanding and prevention of sudden cardiac death', F1000Research, vol. 6, http://dx.doi.org/10.12688/f1000research.11855.1
2017
Phan K; Ng CA; David E; Shishmarev D; Kuchel PW; Vandenberg JI; Perry MD, 2017, 'The S1 helix critically regulates the finely tuned gating of Kv11.1 channels', Journal of Biological Chemistry, vol. 292, pp. 7688 - 7705, http://dx.doi.org/10.1074/jbc.M117.779298
2017
Perry MD; Ng CA; Phan K; David E; Steer K; Hunter MJ; Mann SA; Imtiaz M; Hill AP; Ke Y; Vandenberg JI, 2016, 'Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations', Journal of Physiology, vol. 594, pp. 4031 - 4049, http://dx.doi.org/10.1113/JP271805
2016
Hill AP; Perry MD; Abi-Gerges N; Couderc JP; Fermini B; Hancox JC; Knollmann BC; Mirams GR; Skinner J; Zareba W; Vandenberg JI, 2016, 'Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century', Journal of Physiology, vol. 594, pp. 6893 - 6908, http://dx.doi.org/10.1113/JP272015
2016
Ng CA; Gravel AE; Perry MD; Arnold AA; Marcotte I; Vandenberg JI, 2016, 'Tyrosine residues from the s4-s5 linker of kv11.1 channels are critical for slow deactivation', Journal of Biological Chemistry, vol. 291, pp. 17293 - 17302, http://dx.doi.org/10.1074/jbc.M116.729392
2016
Perry MD; Ng CA; Mann SA; Sadrieh A; Imtiaz M; Hill AP; Vandenberg JI, 2015, 'Getting to the heart of hERG K+ channel gating', Journal of Physiology, vol. 593, pp. 2575 - 2585, http://dx.doi.org/10.1113/JP270095
2015
Fonoudi H; Ansari H; Abbasalizadeh S; Larijani MR; Kiani S; Hashemizadeh S; Zarchi AS; Bosman A; Blue GM; Pahlavan S; Perry M; Orr Y; Mayorchak Y; Vandenberg J; Talkhabi M; Winlaw DS; Harvey RP; Aghdami N; Baharvand H, 2015, 'A universal and robust integrated platform for the scalable production of human cardiomyocytes from pluripotent stem cells', Stem Cells Translational Medicine, vol. 4, pp. 1482 - 1494, http://dx.doi.org/10.5966/sctm.2014-0275
2015
Vandenberg JI; Perry MD, 2014, 'Can many subunits make light work of ion channel inactivation?', Journal of Physiology, vol. 592, pp. 4411 - 4412, http://dx.doi.org/10.1113/jphysiol.2014.281568
2014
Sadrieh A; Domanski L; Pitt-Francis J; Mann SA; Hodkinson EC; Ng CA; Perry MD; Taylor JA; Gavaghan D; Subbiah RN; Vandenberg JI; Hill AP, 2014, 'Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2', Nature Communications, vol. 5, http://dx.doi.org/10.1038/ncomms6069
2014
Ng CA; Phan K; Hill AP; Vandenberg JI; Perry MD, 2014, 'Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels', Journal of Biological Chemistry, vol. 289, pp. 25822 - 25832, http://dx.doi.org/10.1074/jbc.M114.558379
2014
Ke Y; Hunter MJ; Ng CA; Perry MD; Vandenberg JI, 2014, 'Role of the cytoplasmic N-terminal cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels', Journal of Biological Chemistry, vol. 289, pp. 13782 - 13791, http://dx.doi.org/10.1074/jbc.M113.531277
2014
Ng CA; Ke Y; Perry MD; Tan PS; Hill AP; Vandenberg JI, 2013, 'C-Terminal β9-Strand of the Cyclic Nucleotide-Binding Homology Domain Stabilizes Activated States of Kv11.1 Channels', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0077032
2013
Perry MD; Wong S; Ng CA; Vandenberg JI, 2013, 'Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels', Journal of General Physiology, vol. 142, pp. 275 - 288, http://dx.doi.org/10.1085/jgp.201310975
2013
Tan PS; Perry MD; Ng C; Vandenberg JI; Hill A, 2012, 'Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels', Journal of General Physiology, vol. 140, pp. 293 - 306, http://dx.doi.org/10.1085/jgp.201110761
2012
Perry M; Taylor AE, 1988, 'Phorbol myristate acetate-induced injury of isolated perfused rat lungs: Neutrophil dependence', Journal of Applied Physiology, vol. 65, pp. 2164 - 2169
1988
Martin D; Korthuis RJ; Perry M, 1986, 'Oxygen radical-mediated lung damage associated with α-napthylthiourea', Acta Physiologica Scandinavica, vol. 126, pp. 119 - 125
1986
Book Chapters
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Vandenberg JI; Ng CA; Mann SA; Perry MD, 2014, 'Voltage-Gated Potassium Channels (Kv10-Kv12)', in Reference Module in Biomedical Research, http://dx.doi.org/10.1016/B978-0-12-801238-3.04809-1
2014
Conference Abstracts
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Hill AP; Mann SA; Imtiaz MS; Perry MD; Vandenberg JI, 2014, 'Using Clinical Datasets to Optimize Models of Human Ventricular Electrophysiology: Implications for In Silico Drug Screening', in BIOPHYSICAL JOURNAL, CELL PRESS, San Francisco, CA, Vol. 112, pp. 465A - 465A, presented at 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, 15 February 2014 - 19 February 2014, http://dx.doi.org/10.1016/j.bpj.2016.11.2493
2014
Perry MD; Vandenberg JI, 2012, 'Critical Dual Role for the Pore Helix in Kv11.1 Channel Inactivation', in BIOPHYSICAL JOURNAL, CELL PRESS, San Diego, CA, Vol. 102, pp. 328A - 328A, presented at 56th Annual Meeting of the Biophysical-Society, San Diego, CA, 25 February 2012 - 29 February 2012, http://dx.doi.org/10.1016/j.bpj.2011.11.1801
2012
Conference Papers
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Tan PS; Perry M; Chai AN; Vandenberg JI; Hill AP, 2012, 'Bimodal Regulation of hERG Gating by the N-Terminal Tail Revealed by Voltage Clamp Fluorometry', in BIOPHYSICAL JOURNAL, CELL PRESS, San Diego, CA, pp. 328A - 328A, presented at 56th Annual Meeting of the Biophysical-Society, San Diego, CA, 25 February 2012 - 29 February 2012, http://dx.doi.org/10.1016/j.bpj.2011.11.1800
2012