Louise Causer

Senior Lecturer

Louise is a medical epidemiologist and senior lecturer at The Kirby Institute. She has interest and experience across a number of international public health issues, primarily those with an infectious disease focus including HIV, sexually transmissible infections (STIs) and malaria.

Louise completed her  PhD in 2016 at the Kirby Institute UNSW and her work focuses on evaluations of point-of-care (POC) diagnostics for STIs. Louise was a co-investigator on the NHMRC-funded TTANGO trial [Test, Treat and Go] – a large, multisite, randomised controlled trial to evaluate the impact, cost-effectiveness, feasibility and acceptability of a new molecular based point-of-care (POC) test for chlamydia and gonorrhoea in remote community across Australia. The TTANGO2 program builds upon the findings of the trial and is now underway, scaling up POC testing for STIs in remote and regional communities across 4 jurisdictions in Australia.

Prior to joining UNSW, Louise held positions as a medical epidemiologist and Epidemic Intelligence Service Officer (EIS) at the US Centres for Disease Control and Prevention (CDC), medical officer to the polio eradication program at the World Health Organisation (Bangladesh), and research assistant at the UK National Heart Forum and European Centre on Health for Societies in Transition (ECOHOST). Louise completed her clinical medical training with positions in Australia and USA.

Research Interests
Louise has a long standing interest and passion working and conducting research in the field of infectious diseases (including malaria, tuberculosis, HIV and other STIs). Her focus in recent years has been on STIs, including syphilis, chlamydia and gonorrhoea and the potential role and impact for POC tests in remote communities across Australia, PNG and other resource limited settings.

In order for POC tests to be considered for programmatic implementation they must demonstrate accuracy, reliability, acceptability and cost effectiveness in the required setting. Current and future collaborative work with colleagues in Australia and in the Asia Pacific region will evaluate new POC diagnostic platforms for STIs including syphilis, chlamydia, gonorrhoea and trichomonas and investigate the feasibility and scale up of their use in a variety of settings.

Broad Research Areas
Global Health, Infectious Diseases, HIV, STIs, POC diagnostics, operational research, implementation science

Qualifications
MBBS, MScPH, DTM&H, PhD

Specific Research Keywords
STI diagnosis; Point-of-care testing; syphilis; chlamydia; gonorrhoea; Indigenous health; remote Australia

Journal articles
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Saweri OPM; Batura N; Adawiyah RA; Causer L; Pomat W; Vallely A; Wiseman V, 2019, 'Cost and cost-effectiveness of point-of-care testing and treatment for sexually transmitted and genital infections in pregnancy in low-income and middle-income countries: A systematic review protocol', BMJ Open, vol. 9, pp. e029945, http://dx.doi.org/10.1136/bmjopen-2019-029945
2019
Badman SG; Causer LM; Guy R; Wand H; Donovan B; Tabrizi SN; Speers D; Shephard MD; Vallely A; Whiley D; Kaldor J; Wilson D; Regan D; Ward J; Fairley CK; Hengel B; Tangey A; Anderson D; Natoli L; Atkinson D, 2018, 'A reliable and easy to transport quality control method for chlamydia and gonorrhoea molecular point of care testing', Pathology, vol. 50, pp. 317 - 321, http://dx.doi.org/10.1016/j.pathol.2017.09.012
2018
Guy RJ; Ward J; Causer LM; Natoli L; Badman SG; Tangey A; Hengel B; Wand H; Whiley D; Tabrizi SN; Shephard M; Fairley CK; Donovan B; Anderson DA; Regan DG; Maher L; Kaldor JM, 2018, 'Molecular point-of-care testing for chlamydia and gonorrhoea in Indigenous Australians attending remote primary health services (TTANGO): a cluster-randomised, controlled, crossover trial', The Lancet Infectious Diseases, vol. 18, pp. 1117 - 1126, http://dx.doi.org/10.1016/S1473-3099(18)30429-8
2018
Causer LM; Guy RJ; Tabrizi SN; Whiley DM; Speers DJ; Ward J; Tangey A; Badman SG; Hengel B; Natoli LJ; Anderson DA; Wand H; Wilson D; Regan DG; Shephard M; Donovan B; Fairley CK; Kaldor JM, 2018, 'Molecular test for chlamydia and gonorrhoea used at point of care in remote primary healthcare settings: A diagnostic test evaluation', Sexually Transmitted Infections, vol. 94, pp. 340 - 345, http://dx.doi.org/10.1136/sextrans-2017-053443
2018
Utami S; Sawitri AAS; Wulandari LPL; Artawan Eka Putra IWG; Astuti PAS; Wirawan DN; Causer L; Mathers B, 2017, 'Mortality among people living with HIV on antiretroviral treatment in Bali, Indonesia: incidence and predictors', International Journal of STD and AIDS, vol. 28, pp. 1199 - 1207, http://dx.doi.org/10.1177/0956462417692942
2017
Marks M; Yin YP; Chen XS; Castro A; Causer L; Guy R; Wangnapi R; Mitjà O; Aziz A; Castro R; Da Luz Martins Pereira F; Taleo F; Guinard J; Bélec L; Tun Y; Bottomley C; Ballard RC; Mabey DCW, 2016, 'Metaanalysis of the Performance of a Combined Treponemal and Nontreponemal Rapid Diagnostic Test for Syphilis and Yaws', Clinical Infectious Diseases, vol. 63, pp. 627 - 633, http://dx.doi.org/10.1093/cid/ciw348
2016
Badman SG; Causer LM; Guy R; Tabrizi SN; Francis F; Donovan B; Whiley D, 2016, 'A preliminary evaluation of a new GeneXpert (Gx) molecular point-of-care test for the detection of Trichomonas vaginalis', Sexually Transmitted Infections, vol. 92, pp. 350 - 352, http://dx.doi.org/10.1136/sextrans-2015-052384
2016
Badman SG; Vallely LM; Toliman P; Kariwiga G; Lote B; Pomat W; Holmer C; Guy R; Luchters S; Morgan C; Garland SM; Tabrizi S; Whiley D; Rogerson SJ; Mola G; Wand H; Donovan B; Causer L; Kaldor J; Vallely A, 2016, 'A novel point-of-care testing strategy for sexually transmitted infections among pregnant women in high-burden settings: Results of a feasibility study in Papua New Guinea', BMC Infectious Diseases, vol. 16, http://dx.doi.org/10.1186/s12879-016-1573-4
2016
Causer LM; Kaldor JM; Conway DP; Leslie DE; Denham I; Karapanagiotidis T; Ryan C; Wand H; Anderson DA; Robertson PW; McNulty AM; Donovan B; Fairley CK; Guy RJ, 2015, 'An Evaluation of a Novel Dual Treponemal/Nontreponemal Point-of-Care Test for Syphilis as a Tool to Distinguish Active from Past Treated Infection', Clinical Infectious Diseases, vol. 61, pp. 184 - 191, http://dx.doi.org/10.1093/cid/civ243
2015
Bristow CC; Larson E; Javanbakht M; Huang E; Causer L; Klausner JD, 2015, 'A review of recent advances in rapid point-of-care tests for syphilis', Sexual Health, vol. 12, pp. 119 - 125, http://dx.doi.org/10.1071/SH14166
2015
Natoli L; Guy RJ; Shephard M; Causer L; Badman SG; Hengel B; Tangey A; Ward J; Coburn T; Anderson D; Kaldor J; Maher L; Donovan B; Wilson D; Regan D; Wand H; Whiley D; Tabrizi SN; Fairley C, 2015, '"I do feel like a scientist at times": A qualitative study of the acceptability of molecular point-of-care testing for chlamydia and gonorrhoea to primary care professionals in a remote high STI burden setting', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0145993
2015
Causer LM; Hengel B; Natoli L; Tangey A; Badman SG; Tabrizi SN; Whiley D; Ward J; Kaldor JM; Guy RJ, 2015, 'A field evaluation of a new molecular-based point-of-care test for chlamydia and gonorrhoea in remote Aboriginal health services in Australia', Sexual Health, vol. 12, pp. 27 - 33, http://dx.doi.org/10.1071/SH14158
2015
Causer LM; Kaldor JM; Fairley CK; Donovan B; Karapanagiotidis T; Leslie DE; Robertson PW; McNulty AM; Anderson D; Wand H; Conway DP; Denham I; Ryan C; Guy RJ, 2014, 'A laboratory-based evaluation of four rapid point-of-care tests for syphilis', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0091504
2014
Hui BB; Ward J; Causer L; Guy RJ; Law MG; Regan DG, 2014, 'Could point-of-care testing be effective for reducing the prevalence of trichomoniasis in remote Aboriginal communities?', Sexual Health, vol. 11, pp. 370 - 374, http://dx.doi.org/10.1071/SH14035
2014
Guy RJ; Natoli L; Ward J; Causer L; Hengel B; Whiley D; Tabrizi SN; Donovan B; Fairley CK; Badman SB; Tangey A; Wand H; Shephard M; Regan DG; Wilson D; Anderson D; Kaldor JM, 2013, 'A randomised trial of point-of-care tests for chlamydia and gonorrhoea infections in remote Aboriginal communities: Test, Treat ANd GO- the " TTANGO" trial protocol', BMC Infectious Diseases, vol. 13, http://dx.doi.org/10.1186/1471-2334-13-485
2013
Januraga PP; Wulandari LPL; Muliawan P; Sawitri S; Causer L; Wirawan DN; Kaldor JM, 2013, 'Sharply rising prevalence of HIV infection in Bali: A critical assessment of the surveillance data', International Journal of STD and AIDS, vol. 24, pp. 633 - 637, http://dx.doi.org/10.1177/0956462413477556
2013
Uluk T; Allison WE; Vince J; Wand HC; Tefuarani N; Causer LM; Ripa P; Kariko M; Kaminiel O; Cunningham PH; Graham SM; Kaldor JM, 2013, 'Evaluation of an interferon-gamma release assay in children with suspected tuberculosis in Papua New Guinea', Pediatric Infectious Disease Journal, vol. 32, pp. 187 - 189, http://dx.doi.org/10.1097/INF.0b013e31827412fc
2013
Watchirs Smith LA; Hillman R; Ward JW; Whiley DM; Causer LM; Skov S; Donovan B; Kaldor JM; Guy R, 2012, 'Point-of-care tests for the diagnosis of Neisseria gonorrhoeae infection; a systematic review of operational and performance characteristic', Sexually Transmitted Infections, vol. Oct 23, pp. 320 - 326, http://dx.doi.org/10.1136/sextrans-2012-050656
2012
Skarbinski J; Ouma PO; Causer LM; Kariuki SK; Barnwell JW; Alaii JA; De Oliveira AM; Zurovac D; Larson BA; Snow RW; Rowe AK; Laserson KF; Akhwale WS; Slutsker L; Hamel MJ, 2009, 'Effect of malaria rapid diagnostic tests on the management of uncomplicated malaria with artemether-lumefantrine in Kenya: A cluster randomized trial', American Journal of Tropical Medicine and Hygiene, vol. 80, pp. 919 - 926
2009
De Oliveira A; Skarbinski J; Ouma P; Kariuki S; Barnwell J; Otieno K; Onyona P; Causer L; Laserson K; Akhwale W; Slutsker L; Hamel M, 2009, 'Performance of malaria rapid diagnostic tests as part of routine malaria case management in Kenya', American Journal of Tropical Medicine and Hygiene, vol. 80, pp. 470 - 474
2009
Williams HL; Causer L; Metta E; Malila A; O Reilly T; Abdulla S; Kachur S; Bloland P, 2008, 'Dispensary level pilot implementation of rapid diagnostic tests (RDTs): An evaluation of RDT acceptance and usage by providers and patients - Tanzania, 2005.', Malaria Journal, vol. 7, pp. 239, http://dx.doi.org/10.1186/1475-2875-7-239
2008
Shah JJ; Maloney SA; Liu Y; Flagg EW; Johnston SP; Young SA; Weston R; Merritt S; Wilkins PP; Keane V; Calderon J; Sharp DJ; Causer L; Maguire JH; Cetron MS, 2008, 'Evaluation of the impact of overseas pre-departure treatment for infection with intestinal parasites among montagnard refugees migrating from Cambodia to North Carolina', American Journal of Tropical Medicine and Hygiene, vol. 78, pp. 754 - 759
2008
Stauffer WM; Weinberg M; Newman RD; Causer LM; Hamel MJ; Slutsker L; Cetron MS, 2008, 'Pre-departure and post-arrival management of P. falciparum malaria in refugees relocating from sub-Saharan Africa to the United States', American Journal of Tropical Medicine and Hygiene, vol. 79, pp. 141 - 146
2008
Causer LM; Handzel T; Welch P; Carr M; Culp D; Lucht R; Mudahar K; Robinson D; Neaver E; Fenton S; Rose C; Craig L; Arrowood M; Wahlquist S; Xiao L; Lee YM; Mirel L; Levy D; Beach MJ; Poquette G; Dworkin MS, 2006, 'An outbreak of Cryptosporidium hominis infection at an Illinois recreational waterpark', Epidemiology and Infection, vol. 134, pp. 147 - 156, http://dx.doi.org/10.1017/S0950268805004619
2006
Skarbinski J; James EM; Causer LM; Barber AM; Mali S; Nguyen-Dinh P; Roberts JM; Parise ME; Slutsker L; Newman RD, 2006, 'Malaria surveillance--United States, 2004.', MMWR. Surveillance summaries : Morbidity and mortality weekly report. Surveillance summaries / CDC, vol. 55, pp. 23 - 37
2006
Patrick Kachur S; Schulden J; Goodman CA; Kassala H; Elling BF; Khatib RA; Causer LM; Mkikima S; Abdulla S; Bloland PB, 2006, 'Prevalence of malaria parasitemia among clients seeking treatment for fever or malaria at drug stores in rural Tanzania 2004', Tropical Medicine and International Health, vol. 11, pp. 441 - 451, http://dx.doi.org/10.1111/j.1365-3156.2006.01588.x
2006
Muula AS; Causer LM; Filler S; Newman RD, 2005, 'Mismanagement of malaria among travelers in developing countries [7] (multiple letters)', Clinical Infectious Diseases, vol. 40, pp. 1382 - 1383, http://dx.doi.org/10.1086/429512
2005
Lock K; Pomerleau J; Causer L; Altmann DR; McKee M, 2005, 'The global burden of disease attributable to low consumption of fruit and vegetables: Implications for the global strategy on diet', Bulletin of the World Health Organization, vol. 83, pp. 100 - 108
2005
Causer LM; Bishop HS; Sharp DJ; Flagg EW; Calderon JF; Keane V; Shah JJ; Macarthur JR; Maloney SA; Cetron MS; Bloland PB, 2005, 'Rapid malaria screening and targeted treatment of United States-bound Montagnard refugees from Cambodia in 2002', American Journal of Tropical Medicine and Hygiene, vol. 72, pp. 688 - 693
2005
Causer LM; Filler S; Wilson M; Papagiotas S; Newman RD, 2004, 'Evaluation of reported malaria chemoprophylactic failure among travelers in a US University Exchange Program, 2002', Clinical Infectious Diseases, vol. 39, pp. 1583 - 1588, http://dx.doi.org/10.1086/425311
2004
Shah S; Filler S; Causer LM; Rowe AK; Bloland PB; Barber AM; Roberts JM; Desai MR; Parise ME; Steketee RW, 2004, 'Malaria surveillance--United States, 2002.', MMWR. Surveillance summaries : Morbidity and mortality weekly report. Surveillance summaries / CDC, vol. 53, pp. 21 - 34
2004
Rodgers A; Ezzati M; Vander Hoorn S; Lopez AD; Lin RB; Murray CJL; Fishman S; Caulfield LE; de Onis M; Blössner M; Hyder AA; Mullany L; Black RE; Stoltzfus RJ; Rice AJ; West KP; Lawes C; Law M; Elliott P; MacMahon S; James WPT; Jackson-Leach R; Ni Mhurchu C; Kalamara E; Shayeghi M; Rigby NJ; Nishida C; Lock K; Pomerleau J; Causer L; McKee M; Bull FC; Dixon T; Ham S; Neiman A; Pratt M; Rehm J; Room R; Monteiro M; Gmel G; Graham K; Rehn N; Sempos CT; Frick U; Jernigan D; Degenhardt L; Hall W; Warner-Smith M; Lynskey M; Slaymaker E; Walker N; Armstrong T; Collumbien M; Gerressu M; Cleland J; Prüss-Ustun A; Kay D; Fewtrell L; Bartram J; Cohen A; Anderson R; Ostro B; Dev Pandey K; Krzyzanowski M; Künzli N; Gutschmidt K; Pope A; Romieu I; Samet J; Smith K; Smith KR; Mehta S; Feuz M; Landrigan P; Ayuso JL; McMichael A; Campbell-Lendrum D; Kovats S; Edwards S; Wilkinson P; Tanser F; Le Sueur D; Schlesinger M; Andronova N; Nicholls R; Wilson T; Hales S; Concha M; Imel Nelson D; Fingerhut M; Leigh J; Corvalan C; Driscoll T; Kyle Steenland N; Punnett L; Tak SW; Phillips S; Hauri AM; Armstrong GL; Hutin YJF, 2004, 'Distribution of major health risks: Findings from the global burden of disease study', PLoS Medicine, vol. 1, pp. 044 - 055, http://dx.doi.org/10.1371/journal.pmed.0010027
2004
Filler S; Causer LM; Newman RD; Barber AM; Roberts JM; MacArthur J; Parise ME; Steketee RW, 2003, 'Malaria surveillance--United States, 2001.', MMWR. Surveillance summaries : Morbidity and mortality weekly report. Surveillance summaries / CDC, vol. 52, pp. 1 - 14
2003
Johnston SP; Ballard MM; Beach MJ; Causer L; Wilkins PP, 2003, 'Evaluation of three commercial assays for detection of Giardia and Cryptosporidium organisms in fecal specimens', Journal of Clinical Microbiology, vol. 41, pp. 623 - 626, http://dx.doi.org/10.1128/JCM.41.2.623-626.2003
2003
Causer LM, 2002, 'Malaria Surveillance United States 2000', MMWR. Surveillance summaries : Morbidity and mortality weekly report. Surveillance summaries / CDC, http://www.cdc.gov/mmwr/Preview/Mmwrhtml/ss5105a2.htm
2002
Pastor A; Neely J; Goodfriend D; Marr J; Jenkins S; Woolard D; Pettit D; Gaines D; Sockwell D; Garvey C; Jordan C; Lacey C; DuVernoy T; Roberts D; Robert L; Santos P; Wirtz R; MacArthur J; O'Brien M; Causer L, 2002, 'Local transmission of Plasmodium vivax malaria - Virginia, 2002 (Reprinted from MMWR, vol 51, pg 931-923, 2002)', JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, vol. 288, pp. 2113 - 2114, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000179048100011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2002
Other
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Guy RJ; Causer LM; Klausner JD; Unemo M; Toskin I; Azzini AM; Peeling RW, 2017, Performance and operational characteristics of point-of-care tests for the diagnosis of urogenital gonococcal infections, http://dx.doi.org/10.1136/sextrans-2017-053192
2017
Book Chapters
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Shephard M; Causer L; Guy R, 2016, 'Point-of-care testing in rural, remote and Indigenous settings', in Shephard M (ed.), , CSIRO PUBLISHING, Australia, pp. 343 - 354
2016
Natoli L; Causer L; Motta L; Shephard M; Guy R, 2016, 'Point-of-care testing for chlamydia, gonorrhoea and trichominiasis', in Shephard M (ed.), , CSIRO PUBLISHING, Australia, pp. 207 - 219
2016
Conference Papers
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Causer LM; Tangey A; Badman SG; Hengel B; Natoli L; Speers D; Tabrizi SN; Whiley D; Anderson DA; Ward J; Kaldor JM; Guy RJ, 2015, 'OPERATIONAL PERFORMANCE OF A NEW MOLECULAR-BASED POINT-OF-CARE TEST FOR DIAGNOSIS OF CHLAMYDIA TRACHOMATIS AND NEISSERIA GONORRHOEAE INFECTION: CONCORDANCE WITH CONVENTIONAL LABORATORY TESTING', in SEXUALLY TRANSMITTED INFECTIONS, BMJ PUBLISHING GROUP, pp. A28 - A28, http://dx.doi.org/10.1136/sextrans-2015-052270.86
2015
Badman SG; Vallely LM; Toliman P; Kariwiga G; Tabrizi S; Pomat W; Guy R; Homer C; Luchters S; Morgan C; Garland SM; Rogerson S; Whiley D; Mola GDL; Wand H; Donovan B; Causer L; Siba P; Kaldor JM; Vallely A, 2015, 'POINT-OF-CARE TESTING AND IMMEDIATE TREATMENT OF CURABLE SEXUALLY TRANSMITTED AND GENITAL INFECTIONS AMONG ANTENATAL WOMEN IN PAPUA NEW GUINEA', in SEXUALLY TRANSMITTED INFECTIONS, BMJ PUBLISHING GROUP, pp. A27 - A27, http://dx.doi.org/10.1136/sextrans-2015-052270.85
2015
Conference Presentations
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Hengel B; Badman S; Causer L; Natoli L; Tangey A; Ward J; Tabrizi S; Whiley D; Donovan B; Fairley CK; Wilson D; Regan D; Wand H; Shephard M; Anderson D; Kaldor J; Guy R, 2014, 'TTANGO: OPERATIONAL PERFORMANCE OF A MOLECULAR BASED CHLAMYDIA AND GONORRHOEA POINT-OF-CARE TESTING IN REMOTE AUSTRALIAN ABORIGINAL COMMUNITIES', Vol. 41, pp. S88 - S88, presented at STD Prevention Conference, Atlanta, GA, 09 June 2014 - 12 June 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352051500309&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2014
Causer L; Kaldor J; Karapanagiotidis T; Ryan C; Wand H; Conway D; Denham I; Anderson D; Robertson P; Leslie D; McNulty A; Donovan B; Fairley C; Guy R, 'Can a new dual detection point-of-care test for syphilis be used to reduce over-diagnosis of active infection in high prevalence populations?', presented at Australasian Sexual Health Conference, Darwin, 23 October 2013 - 25 October 2013
Causer L; Tangey A; Badman S; Hengel B; Natoli L; Speers D; Tabrizi S; Whiley D; Anderson D; Ward J; Kaldor J; Guy R, 'Operational performance of a new molecular-based point-of-care test for diagnosis of CT and NG infections: concordance with conventional laboratory testing', presented at Australian Society for Microbiolgy, Canberra, 13 April 2015 - 15 July 2015
Causer L; Andrewartha K; Walley B; Smith K; Shephard M; Wand H; Richards J; Badman S; Tangey A; Marshall-Lang R; Guy R, 'Sustainability of point-of-care testing for sexually transmissible infections in remote communities in Australia - transition from trial to program', presented at IUSTI Asia Pacific Sexual Health COngress 2018, Aukland, New Zealand, 01 November 2018 - 03 November 2018
Conference Posters
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Huang R-L; Ward J; Causer L; Tangey A; Guy R, 'New rapid molecular test improves uptake and timeliness of treatment for CT and NG in a remote Aboriginal Health Clinic', Brisbane, presented at Worl STI and HIV Congress, Brisbane, 13 September 2015 - 15 September 2015

NHMRC PhD Scholarship (2013-2015)

NHMRC Early Career Research Fellowship (2019 - 2022)

NHMRC Research Excellence Award - Frank Fenner Early Career Fellowship 2018

2019 - Kirby Institute Cooper HIV AIDS Research Training (CHART) Program - Course convenor, lecturer and mentor

2020 - Medicine Phase 1 Facilitator (TP2 BGD)