Research interests are G-Protein Coupled Receptor (GPCR), activation and regulation by drugs. The mechanisms of GPCR activation are being explored via: (i) investigating the role of the extracellular loops in regulating the activation of GPCRs and as a site of interaction with allosteric modulator drugs in adrenergic, inflammatory (C5aR) and taste receptors (ii) a drug discovery program which is developing urogenital selective α1-adrenoceptor antagonists for the treatment of prostate diseases and adrenoceptor modulators for Rett syndrome, seizure disorders and other neurological conditions.
Broad Research Areas:
Pharmacology, Molecular Structure & Drug Design
Society Memberships & Professional Activities:
Specific Research Keywords:
G-protein Coupled Receptors, Drug Discovery, Molecular Mechanisms, Pharmacology, Cell Biology, Adrenoceptor, Complement Receptor 5a, Taste Receptors