Abhirup Das

Adjunct Lecturer

Research Focus

My research goals are to understand (1) why muscle health declines with age and (2) how to promote muscle regeneration and repair after injury in the elderly . I have strong experience in chemistry, along with specialist expertise in biochemistry and physiology that have been honed over the years by working at highly esteemed research institutions across the globe. My dual background in chemistry and biology enables me to utilize interdisciplinary approaches to solve critical biological problems. My current research focuses on understanding the roles of key signaling molecules and metabolites in muscle repair and regeneration after traumatic injury. I have recently identified the key pathways that regulate muscle health during ageing and novel interventions to reverse age-associated decline in blood flow and endurance in mice. 

  • Sirtuins and NAD+ metabolism in aging and age-related diseases
  • Wound healing in diabetes and ageing
  • Muscle injury and stem cells

Google Scholar Profile

Why we get frail and how to reverse it

Old mice are new again: anti-ageing pill restores vitality

Rewinding the clock

    Professional Experience

    • Visiting Scientist, Harvard Medical School, USA (2016 - current)
    • Postdoctoral Fellow, School of Medical Sciences, UNSW Australia (2014 - current)
    • Glenn Postdoctoral Fellow, Department of Biology, Massachusetts Institute of Technology, USA (2010 - 2014)
    • Graduate Student Researcher, Department of Chemistry, Stanford University, USA (2004 - 2010)

      Invited Talks

      • ComBio Conference (Co-chair), Adelaide (2017)
      • Australian Society for Molecular Imaging Symposium, University of Sydney (2017)
      • International Dose Response Society Annual Conference, University of Massachusetts Amherst (2017)

      Talks selected from Abstract

      • Mechanisms of Aging, Cold Spring Harbor Laboratory, US (2016)
      • Australian Biology of Ageing Conference, Sydney (2016)
      • Australian Physiological Society Annual Conference, Hobart (2015)
      • UNSW Metabolism Meeting, UNSW Sydney (2015)
      • Medicinal Chemistry and Drug Discovery Symposium, UNSW Sydney (2015)
      • Australian Diabetes Society Annual Scientific Meeting, Adelaide (2015)

      Poster

      • 3rd Australian Biology of Ageing Conference, Brisbane (2018)
      • Australian Physiological Society Annual Conference, Adelaide (2016)
      • Annual Biology Retreat, Massachusetts Institute of Technology (2014)
      • Annual MIT Postdocs Share Their Science Symposium, Massachusetts Institute of Technology (2014)
      • 24th Annual Johnson Symposium, Stanford University (2009)

      Publications

      1. Turner, N.*; Lim, X.Y.*; Toop, H.D.; Osborne, B.; Brandon, A.E.; Taylor, E.N.; Fiveash, C.E.; Govindaraju, H.; Teo, J.; McEwen, H.P.; Couttas, T.A.; Butler, S.M.; Das, A.; Kowalski, G.M.; Bruce, C.R.; Hoehn, K.L.; Fath, T.; Schmitz-Peiffer, C.; Cooney, G.J.; Montgomery, M.K.; Morris, J.C.; Don, A.S. “A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism.” Nature Communications 2018, in press.
      2. Das, A.; Huang G.; Bonkowski, M.; Longchamp A.; Li, C.; Schultz, M.B.; Kim, L.J.; Osborne, B.; Joshi, S.; Lu, Y.; Treviño-Villarreal, J.H.;Kang, M.J.; Hung, T.; Lee, B.; Williams, E.W.; Igarashi, M.; Mitchell, J.R.; Wu, L.E.; Turner, N.; Arany, Z.; Guarente, L.P.; Sinclair, D.A. “Impairment of an endothelial NAD+-H2S signaling network is a reversible cause of vascular aging.” Cell 2018, 173, 74-89.
      3. Longchamp, A.*; Mirabella, T.*; Arduini, A.*; MacArthur, M.; Das, A.; Treviño-Villarreal, J.H.; Hine, C.; Ben-Sahra, I.; Knudsen, N.; Brace, L.E.; Reynolds, J.; Mejia, P.; Tao, M.; Sharma, G.; Wang, R.; Corpataux, J.M.; Haefliger, J.A.; Ahn, K.H.; Lee, C.H.; Manning, B.M.; Sinclair, D.A.; Chen, C.; Ozaki, C.K., Mitchell, J.R. “Amino acid restriction triggers angiogenesis via GCN2/ATF4 regulation of VEGF and H2S production.” Cell 2018, 173, 117-129.
      4. Das, A.; Sinclair, D.; Bonkowski, M.; Johnston, I.; Wu, L. “Extension of physical endurance and protection against physical, chemical and radiological trauma by NAD+precursors.” Journal of Science and Medicine in Sports 2017,20(2), S165-S166.
      5. Chowdhury, Md. K; Turner, N.; Bentley, N.; Das, A.; Wu, L.; Richani, D.; Bustamante, S.; Gilchrist, R.; Morris, M.; Shepherd, P.; Smith, G. “Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes.” Scientific Reports 2017, 7, 40159.
      6. Mohamad, M; Mitchell, S. J.; Wu, L. E.; White, M. Y.; Cordwell, S. J.; Mach, J.; SolonBiet, S. M.; Boyer, D.; Nines, D.; Das, A.; Li, C.; Warren, A.; Hilmer, S. N.; Fraser, R.; Sinclair, D. A.; Simpson, S. J.; Cabo, R.; Le Couteur, D. G.; Cogger, V. C. “Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for agerelated insulin resistance.” Aging Cell 2016, 15(4), 706-715.
      7. Libert, S.; Pointer, K.; Bell, E. L.; Das, A.; Cohen, D. E.; Asara, J. M.; Kapur, K.; Bergmann, S.; Preisig, M.; Otowa, T.; Kendler, K. S.; Chen, X.; Hettema, J. M.; van den Oord, E. J.; Rubio, J. P.; Guarente, L. “SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive.” Cell 2011, 147(7), 1459-1472.
      8. Szu, Ping-Hui; Govindarajan, S.; Meehan, M. J.; Das, A.; Nguyen, D. D.; Dorrestein, P. C.; Minshull, J.; Khosla, C. “Analysis of the ketosynthase-chain length factor heterodimer from the fredericamycin polyketide synthase.” Chemistry and Biology 2011, 18, 1021-1031.
      9. Javidpour, P.; Das, A.; Khosla, C.; Tsai, S. "Structural and Biochemical Studies of the Hedamycin Type II Polyketide Ketoreductase (HedKR): Molecular Basis of Stereo- and Regio-Specificities." Biochemistry 2011, 50, 7426-7439.
      10. Das, A.; Szu, Ping-Hui, Fitzgerald, J. T., Khosla, C. “Mechanism and engineering of polyketide chain initiation in fredericamycin biosynthesis.” J. Am. Chem. Soc. 2010, 132, 8831-8833.
      11. Tahanian, E.; Lord-Dufour, S.; Das, A.; Khosla, C.; Roy, R.; Annabi, B. “Inhibition of tubulogenesis and of carcinogen-mediated signaling in brain endothelial cells highlight antiangiogenic properties of a mumbaistatin analog.” Chemical Biology and Drug Design 2010, 75, 481-488.
      12. Das, A.; Khosla, C. “In vivo and in vitro analysis of the hedamycin polyketide synthase.” Chemistry and Biology 2009, 16, 1197-1207.
      13. Das, A.; Khosla, C. “Biosynthesis of aromatic polyketides in bacteria.” Accounts of Chemical Research 2009, 42, 631-639.
      14. Lord-Dufour, S.; Copland, I.B.; Levros, L.C. Jr.; Post, M.; Das, A.; Khosla, C.; Galipeau, J.; Rassart, E.; Annabi, B. “Evidence for transcriptional regulation of the glucose-6-phosphate transporter by HIF-1{alpha}: Targeting G6PT with mumbaistatin analogs in hypoxic mesenchymal stromal cells.” Stem Cells 2009, 27, 489–497.
      15. Lee, T.S.; Das, A.; Khosla, C. “Structure-activity relationships of semisynthetic Mumbaistatin analogs.” Bioorganic and Medicinal Chemistry 2007, 15, 5207-5218.

      Publications

      Journal articles
      add
      Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2019, 'Erratum: Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging (Cell (2018) 173(1) (74–89.e20), (S0092867418301521) (10.1016/j.cell.2018.02.008))', Cell, vol. 176, pp. 944 - 945, http://dx.doi.org/10.1016/j.cell.2019.01.026
      2019
      Youngson NA; Mezbah Uddin G; Das A; Martinez C; Connaughton HS; Whiting S; Yu J; Sinclair DA; John Aitken R; Morris MJ, 2019, 'Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice', Reproduction, vol. 158, pp. 169 - 179, http://dx.doi.org/10.1530/REP-18-0574
      2019
      Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2018, 'Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging', Cell, vol. 173, pp. 74 - 89.e20, http://dx.doi.org/10.1016/j.cell.2018.02.008
      2018
      Longchamp A; Mirabella T; Arduini A; MacArthur MR; Das A; Treviño-Villarreal JH; Hine C; Ben-Sahra I; Knudsen NH; Brace LE; Reynolds J; Mejia P; Tao M; Sharma G; Wang R; Corpataux JM; Haefliger JA; Ahn KH; Lee CH; Manning BD; Sinclair DA; Chen CS; Ozaki CK; Mitchell JR, 2018, 'Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production', Cell, vol. 173, pp. 117 - 129.e14, http://dx.doi.org/10.1016/j.cell.2018.03.001
      2018
      Turner N; Lim XY; Toop HD; Osborne B; Brandon AE; Taylor EN; Fiveash CE; Govindaraju H; Teo JD; McEwen HP; Couttas TA; Butler SM; Das A; Kowalski GM; Bruce CR; Hoehn KL; Fath T; Schmitz-Peiffer C; Cooney GJ; Montgomery MK; Morris JC; Don AS, 2018, 'A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-05613-7
      2018
      Chowdhury MKH; Turner N; Bentley NL; Das A; Wu LE; Richani D; Bustamante S; Gilchrist RB; Morris MJ; Shepherd PR; Smith GC, 2017, 'Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/srep40159
      2017
      Mohamad M; Mitchell SJ; Wu LE; White MY; Cordwell SJ; Mach J; Solon-Biet SM; Boyer D; Nines D; Das A; Catherine Li SY; Warren A; Hilmer SN; Fraser R; Sinclair DA; Simpson SJ; de Cabo R; Le Couteur DG; Cogger VC, 2016, 'Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance', Aging Cell, vol. 15, pp. 706 - 715, http://dx.doi.org/10.1111/acel.12481
      2016
      Javidpour P; Das A; Khosla C; Tsai SC, 2011, 'Structural and biochemical studies of the hedamycin type II polyketide ketoreductase (Hed KR): Molecular basis of stereo- and regiospecificities', Biochemistry, vol. 50, pp. 7426 - 7439, http://dx.doi.org/10.1021/bi2006866
      2011
      Libert S; Pointer K; Bell EL; Das A; Cohen DE; Asara JM; Kapur K; Bergmann S; Preisig M; Otowa T; Kendler KS; Chen X; Hettema JM; Van Den Oord EJ; Rubio JP; Guarente L, 2011, 'SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive', Cell, vol. 147, pp. 1459 - 1472, http://dx.doi.org/10.1016/j.cell.2011.10.054
      2011
      Szu PH; Govindarajan S; Meehan MJ; Das A; Nguyen DD; Dorrestein PC; Minshull J; Khosla C, 2011, 'Analysis of the ketosynthase-chain length factor heterodimer from the fredericamycin polyketide synthase', Chemistry and Biology, vol. 18, pp. 1021 - 1031, http://dx.doi.org/10.1016/j.chembiol.2011.07.015
      2011
      Tahanian E; Lord-Dufour S; Das A; Khosla C; Roy R; Annabi B, 2010, 'Inhibition of tubulogenesis and of carcinogen-mediated signaling in brain endothelial cells highlight the antiangiogenic properties of a mumbaistatin analog', Chemical Biology and Drug Design, vol. 75, pp. 481 - 488, http://dx.doi.org/10.1111/j.1747-0285.2010.00961.x
      2010
      Das A; Szu PH; Fitzgerald JT; Khosla C, 2010, 'Mechanism and engineering of polyketide chain initiation in fredericamycin biosynthesis', Journal of the American Chemical Society, vol. 132, pp. 8831 - 8833, http://dx.doi.org/10.1021/ja102517q
      2010
      Lord-Dufour S; Copland IB; Levros LC; Post M; Das A; Khosla C; Galipeau J; Rassart E; Annabi B, 2009, 'Evidence for transcriptional regulation of the glucose-6-phosphate transporter by HIF-1α: Targeting G6PT with mumbaistatin analogs in hypoxic mesenchymal stromal cells', Stem Cells, vol. 27, pp. 489 - 497, http://dx.doi.org/10.1634/stemcells.2008-0855
      2009
      Das A; Khosla C, 2009, 'In Vivo and In Vitro Analysis of the Hedamycin Polyketide Synthase', Chemistry and Biology, vol. 16, pp. 1197 - 1207, http://dx.doi.org/10.1016/j.chembiol.2009.11.005
      2009
      Das A; Khosla C, 2009, 'Biosynthesis of Aromatic Polyketides in Bacteria', Accounts of Chemical Research, vol. 42, pp. 631 - 639, http://dx.doi.org/10.1021/ar8002249
      2009
      Lee TS; Das A; Khosla C, 2007, 'Structure-activity relationships of semisynthetic mumbaistatin analogs', Bioorganic and Medicinal Chemistry, vol. 15, pp. 5207 - 5218, http://dx.doi.org/10.1016/j.bmc.2007.05.019
      2007