Abhirup Das

Adjunct Lecturer
Journal articles
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Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2019, 'Erratum: Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging (Cell (2018) 173(1) (74–89.e20), (S0092867418301521) (10.1016/j.cell.2018.02.008))', Cell, vol. 176, pp. 944 - 945, http://dx.doi.org/10.1016/j.cell.2019.01.026
2019
Youngson NA; Mezbah Uddin G; Das A; Martinez C; Connaughton HS; Whiting S; Yu J; Sinclair DA; John Aitken R; Morris MJ, 2019, 'Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice', Reproduction, vol. 158, pp. 169 - 179, http://dx.doi.org/10.1530/REP-18-0574
2019
Turner N; Lim XY; Toop HD; Osborne B; Brandon AE; Taylor EN; Fiveash CE; Govindaraju H; Teo JD; McEwen HP; Couttas TA; Butler SM; Das A; Kowalski GM; Bruce CR; Hoehn KL; Fath T; Schmitz-Peiffer C; Cooney GJ; Montgomery MK; Morris JC; Don AS, 2018, 'A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-05613-7
2018
Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2018, 'Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging', Cell, vol. 173, pp. 74 - 89.e20, http://dx.doi.org/10.1016/j.cell.2018.02.008
2018
Longchamp A; Mirabella T; Arduini A; MacArthur MR; Das A; Treviño-Villarreal JH; Hine C; Ben-Sahra I; Knudsen NH; Brace LE; Reynolds J; Mejia P; Tao M; Sharma G; Wang R; Corpataux JM; Haefliger JA; Ahn KH; Lee CH; Manning BD; Sinclair DA; Chen CS; Ozaki CK; Mitchell JR, 2018, 'Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production', Cell, vol. 173, pp. 117 - 129.e14, http://dx.doi.org/10.1016/j.cell.2018.03.001
2018
Chowdhury MKH; Turner N; Bentley NL; Das A; Wu LE; Richani D; Bustamante S; Gilchrist RB; Morris MJ; Shepherd PR; Smith GC, 2017, 'Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/srep40159
2017
Mohamad M; Mitchell SJ; Wu LE; White MY; Cordwell SJ; Mach J; Solon-Biet SM; Boyer D; Nines D; Das A; Catherine Li SY; Warren A; Hilmer SN; Fraser R; Sinclair DA; Simpson SJ; de Cabo R; Le Couteur DG; Cogger VC, 2016, 'Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance', Aging Cell, vol. 15, pp. 706 - 715, http://dx.doi.org/10.1111/acel.12481
2016
Szu PH; Govindarajan S; Meehan MJ; Das A; Nguyen DD; Dorrestein PC; Minshull J; Khosla C, 2011, 'Analysis of the ketosynthase-chain length factor heterodimer from the fredericamycin polyketide synthase', Chemistry and Biology, vol. 18, pp. 1021 - 1031, http://dx.doi.org/10.1016/j.chembiol.2011.07.015
2011
Javidpour P; Das A; Khosla C; Tsai SC, 2011, 'Structural and biochemical studies of the hedamycin type II polyketide ketoreductase (Hed KR): Molecular basis of stereo- and regiospecificities', Biochemistry, vol. 50, pp. 7426 - 7439, http://dx.doi.org/10.1021/bi2006866
2011
Libert S; Pointer K; Bell EL; Das A; Cohen DE; Asara JM; Kapur K; Bergmann S; Preisig M; Otowa T; Kendler KS; Chen X; Hettema JM; Van Den Oord EJ; Rubio JP; Guarente L, 2011, 'SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive', Cell, vol. 147, pp. 1459 - 1472, http://dx.doi.org/10.1016/j.cell.2011.10.054
2011
Tahanian E; Lord-Dufour S; Das A; Khosla C; Roy R; Annabi B, 2010, 'Inhibition of tubulogenesis and of carcinogen-mediated signaling in brain endothelial cells highlight the antiangiogenic properties of a mumbaistatin analog', Chemical Biology and Drug Design, vol. 75, pp. 481 - 488, http://dx.doi.org/10.1111/j.1747-0285.2010.00961.x
2010
Das A; Szu PH; Fitzgerald JT; Khosla C, 2010, 'Mechanism and engineering of polyketide chain initiation in fredericamycin biosynthesis', Journal of the American Chemical Society, vol. 132, pp. 8831 - 8833, http://dx.doi.org/10.1021/ja102517q
2010
Das A; Khosla C, 2009, 'Biosynthesis of Aromatic Polyketides in Bacteria', Accounts of Chemical Research, vol. 42, pp. 631 - 639, http://dx.doi.org/10.1021/ar8002249
2009
Lord-Dufour S; Copland IB; Levros LC; Post M; Das A; Khosla C; Galipeau J; Rassart E; Annabi B, 2009, 'Evidence for transcriptional regulation of the glucose-6-phosphate transporter by HIF-1α: Targeting G6PT with mumbaistatin analogs in hypoxic mesenchymal stromal cells', Stem Cells, vol. 27, pp. 489 - 497, http://dx.doi.org/10.1634/stemcells.2008-0855
2009
Das A; Khosla C, 2009, 'In Vivo and In Vitro Analysis of the Hedamycin Polyketide Synthase', Chemistry and Biology, vol. 16, pp. 1197 - 1207, http://dx.doi.org/10.1016/j.chembiol.2009.11.005
2009
Lee TS; Das A; Khosla C, 2007, 'Structure-activity relationships of semisynthetic mumbaistatin analogs', Bioorganic and Medicinal Chemistry, vol. 15, pp. 5207 - 5218, http://dx.doi.org/10.1016/j.bmc.2007.05.019
2007
  • CRO MetroBiotech International: Testing the efficacy of NAD precursors in wound healing using mouse models (2018 - present)

  • UNSW RIS_LSCI_MWAC (Associate Investigator): Laser Speckle Imaging Equipment Grant (2017)

  • NHMRC APP1093643 (Associate Investigator): New drugs to prevent premature ageing and side effects of chemotherapy (2015 - 2018)

  • Paul F. Glenn Postdoctoral Fellowship, Massachusetts Institute of Technology: Molecular dynamics of Sirtuin enzymes (2010 - 2014)

  • National Institute of Health Quantitative Chemical Biology Fellowship, Stanford University: Polyketide biosynthesis (2005 - 2008)

  • Metabolism
  • Ageing 
  • Musculoskeletal Disorders
  • Spine and Spinal Cord Dysfunction