Infectious Disease, Immunity & Inflammation

Response

We are well recognised for our research into HIV and hepatitis C (HCV) infections, primarily through the Kirby Institute for Infection and Immunity in Society. The Kirby Institute is a centre of excellence and Australia’s premier infectious diseases research institute, and co-ordinates national surveillance programs, population health and epidemiological research, clinical research and clinical trials. It has an increasingly regional focus involving major collaborative programs in Thailand and Cambodia.

Research groups across the School of Medical Sciences, Prince of Wales Clinical School and School of Public Health and Community Medicine conduct basic pathophysiological studies of inflammation and immune responses, using state-of-the-art laboratory techniques such as next generation sequencing, microarray and mass spectrometry to understand a range of diseases including arthritis, inflammatory bowel disease, asthma, and other auto-immune diseases.

We have a critical mass of expertise in vaccinology, with a focus on vaccine effectiveness for influenza, pneumococcus, zoster, HPV and pertussis.

We are working to establish new diagnoses in patients with complex, undifferentiated primary immuno-deficiencies, define their molecular/functional defects, and guide treatment through an alliance of basic scientists, geneticists and adult/paediatric clinical immunologists.

We are also working to identify new auto antigens and guide therapy to treat autoimmune diseases. We are well recognised for guiding the management of childhood diabetes, for our studies into diagnosing and treating neuroinflammation such as multiple sclerosis and motor neurone disease, and for screening autoimmune patients for genetic predispositions.

Through the Sydney Children’s Hospitals Network, we monitor prevalence and incidence of anaphylaxis and develop standard protocols for diagnosis, prevention and treatment of allergic conditions.