Yin Xu

Research Fellow

Yin completed her PhD at the Kirby Institute in 2016. She is currently a postdoctoral research fellow with the Immunovirology Pathogenesis Program at the Kirby Insitute. She is interested in the development of T follicular helper (Tfh) cells in lymph nodes from human volunteers, including healthy adults during routine vaccination, and HIV+ subjects undergoing brief antiretroviral therapy interruption.

publications

Journal articles
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Xu Y; Ollerton MT; Connick E, 2019, 'Follicular T-cell subsets in HIV infection: recent advances in pathogenesis research', Current Opinion in HIV and AIDS, vol. 14, pp. 71 - 76, http://dx.doi.org/10.1097/COH.0000000000000525
2019
Hey-Nguyen WJ; Bailey M; Xu Y; Suzuki K; Van Bockel D; Finlayson R; Leigh Brown A; Carr A; Cooper DA; Kelleher AD; Koelsch KK; Zaunders JJ, 2019, 'HIV-1 DNA Is Maintained in Antigen-Specific CD4+ T Cell Subsets in Patients on Long-Term Antiretroviral Therapy Regardless of Recurrent Antigen Exposure', AIDS Research and Human Retroviruses, vol. 35, pp. 112 - 120, http://dx.doi.org/10.1089/aid.2018.0235
2019
Phetsouphanh C; Xu Y; Munier ML; Zaunders JJ; Kelleher AD, 2017, 'Single-cell profiling of lineage determining transcription factors in antigen-specific CD4+ T cells reveals unexpected complexity in recall responses during immune reconstitution', Immunology and Cell Biology, vol. 95, pp. 640 - 646, http://dx.doi.org/10.1038/icb.2017.28
2017
Xu Y; Phetsouphanh C; Suzuki K; Aggrawal A; Graff-Dubois S; Roche M; Bailey M; Alcantara S; Cashin K; Sivasubramaniam R; Koelsch KK; Autran B; Harvey R; Gorry PR; Moris A; Cooper DA; Turville S; Kent SJ; Kelleher AD; Zaunders J, 2017, 'HIV-1 and SIV predominantly use CCR5 expressed on a precursor population to establish infection in T follicular helper cells', Frontiers in Immunology, vol. 8, http://dx.doi.org/10.3389/fimmu.2017.00376
2017
Hey-Nguyen WJ; Xu Y; Pearson CF; Bailey M; Suzuki K; Tantau R; Obeid S; Milner B; Field A; Carr A; Bloch M; Cooper DA; Kelleher AD; Zaunders JJ; Koelsch KK, 2017, 'Quantification of Residual Germinal Center Activity and HIV-1 DNA and RNA Levels Using Fine Needle Biopsies of Lymph Nodes during Antiretroviral Therapy', AIDS Research and Human Retroviruses, vol. 33, pp. 648 - 657, http://dx.doi.org/10.1089/aid.2016.0171
2017
Koelsch KK; Rasmussen TA; Hey-Nguyen WJ; Pearson C; Xu Y; Bailey M; Marks KH; Sasson SC; Taylor MS; Tantau R; Obeid S; Milner B; Morrissey O; Pinto AN; Suzuki K; Busch MP; Keating SM; Kaiser P; Yukl S; Wong JK; Hiener BM; Palmer S; Zaunders J; Post JJ; Chan DJ; Avery S; Milliken ST; Kelleher AD; Lewin SR; Cooper DA, 2017, 'Impact of Allogeneic Hematopoietic Stem Cell Transplantation on the HIV Reservoir and Immune Response in 3 HIV-Infected Individuals', Journal of Acquired Immune Deficiency Syndromes, vol. 75, pp. 328 - 337, http://dx.doi.org/10.1097/QAI.0000000000001381
2017
Li J; Hardy K; Phetsouphanh C; Tu WJ; Sutcliffe EL; McCuaig R; Sutton CR; Zafar A; Mee Ling Munier C; Zaunders JJ; Xu Y; Theodoratos A; Tan A; SiewLim P; Knaute T; Masch A; Zerweck J; Brezar V; Milburn PJ; Dunn J; Casarotto MG; Turner SJ; Seddiki N; Kelleher AD; Rao S, 2016, 'Nuclear PKC-θ facilitates rapid transcriptional responses in human memory CD4+T cells through p65 and H2B phosphorylation', Journal of Cell Science, vol. 129, pp. 2448 - 2461, http://dx.doi.org/10.1242/jcs.181248
2016
Munier CML; van Bockel D; Bailey M; Ip S; Xu Y; Alcantara S; Liu SM; Denyer G; Kaplan W; Suzuki K; Croft N; Purcell A; Tscharke D; Cooper DA; Kent SJ; Zaunders JJ; Kelleher AD, 2016, 'The primary immune response to Vaccinia virus vaccination includes cells with a distinct cytotoxic effector CD4 T-cell phenotype', Vaccine, vol. 34, pp. 5251 - 5261, http://dx.doi.org/10.1016/j.vaccine.2016.09.009
2016
Zaunders J; Danta M; Bailey M; Mak G; Marks K; Seddiki N; Xu Y; Templeton DJ; Cooper DA; Boyd MA; Kelleher AD; Koelsch KK, 2016, 'CD4+ T follicular helper and IgA+ B cell numbers in gut biopsies from HIV-infected subjects on antiretroviral therapy are similar to HIV-uninfected individuals', Frontiers in Immunology, vol. 7, http://dx.doi.org/10.3389/fimmu.2016.00438
2016
Phetsouphanh C; Xu Y; Zaunders J, 2015, 'CD4 T cells mediate both positive and negative regulation of the immune response to HIV infection: Complex role of T follicular helper cells and regulatory T cells in pathogenesis', Frontiers in Immunology, vol. 6, http://dx.doi.org/10.3389/fimmu.2014.00681
2015
Colineau L; Rouers A; Yamamoto T; Xu Y; Urrutia A; Pham HP; Cardinaud S; Samri A; Dorgham K; Coulon PG; Cheynier R; Hosmalin A; Oksenhendler E; Six A; Kelleher AD; Zaunders J; Koup RA; Autran B; Moris A; Graff-Dubois S, 2015, 'HIV-infected spleens present altered follicular helper T cell (Tfh) subsets and skewed B cell maturation', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0140978
2015
Seddiki N; Cook L; Hsu DC; Phetsouphanh C; Brown K; Xu Y; Kerr SJ; Cooper DA; Munier CML; Pett S; Ananworanich J; Zaunders J; Kelleher AD, 2014, 'Human antigen-specific CD4+CD25+CD134+CD39+ T cells are enriched for regulatory T cells and comprise a substantial proportion of recall responses', European Journal of Immunology, vol. 44, pp. 1644 - 1661, http://dx.doi.org/10.1002/eji.201344102
2014
Murray JM; Zaunders JJ; McBride KL; Xu Y; Bailey M; Suzuki K; Cooper DA; Emery S; Kelleher AD; Koelsch KK, 2014, 'HIV DNA subspecies persist in both activated and resting memory CD4+ T cells during antiretroviral therapy', Journal of Virology, vol. 88, pp. 3516 - 3526, http://dx.doi.org/10.1128/JVI.03331-13
2014
Phetsouphanh C; Xu Y; Bailey M; Pett S; Zaunders J; Seddiki N; Kelleher AD, 2014, 'Ratios of effector to central memory antigen-specific CD4 + T cells vary with antigen exposure in HIV+ patients', Immunology and Cell Biology, vol. 92, pp. 384 - 388, http://dx.doi.org/10.1038/icb.2013.101
2014
McBride K; Xu Y; Bailey M; Seddiki N; Suzuki K; Murray JM; Gao Y; Yan C; Cooper DA; Kelleher AD; Koelsch KK; Zaunders J, 2013, 'The majority of HIV type 1 DNA in circulating CD4+ T lymphocytes is present in non-gut-homing resting memory CD4+ T cells', AIDS Research and Human Retroviruses, vol. 29, pp. 1330 - 1339, http://dx.doi.org/10.1089/aid.2012.0351
2013
Xu Y; Weatherall CJ; Bailey MR; Alcantara S; De Rose R; Estaquier J; Wilson KM; Suzuki K; Corbeil J; Cooper DA; Kent SJ; Kelleher AD; Zaunders J, 2013, 'Simian immunodeficiency virus infects follicular helper CD4 T cells in lymphoid tissues during pathogenic infection of pigtail macaques', Journal of Virology, vol. 87, pp. 3760 - 3773, http://dx.doi.org/10.1128/JVI.02497-12
2013
Seddiki N; Phetsouphanh C; Swaminathan S; Xu Y; Rao S; Li J; Sutcliffe E; Denyer G; Finlayson R; Gelgor L; Cooper DA; Zaunders J; Kelleher AD, 2013, 'The microRNA-9/B-lymphocyte-induced maturation protein-1/IL-2 axis is differentially regulated in progressive HIV infection', European Journal of Immunology, vol. 43, pp. 510 - 520, http://dx.doi.org/10.1002/eji.201242695
2013
Phetsouphanh C; Xu Y; Amin J; Seddiki N; Procopio F; Sekaly RP; Zaunders JJ; Kelleher AD, 2013, 'Characterization of Transcription Factor Phenotypes within Antigen-Specific CD4+ T Cells Using Qualitative Multiplex Single-Cell RT-PCR', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0074946
2013
Xu Y; Foong F, 2008, 'Characterization of a cellulose binding domain from Clostridium cellulovorans endoglucanase-xylanase D and its use as a fusion partner for soluble protein expression in Escherichia coli', Journal of Biotechnology, vol. 135, pp. 319 - 325, http://dx.doi.org/10.1016/j.jbiotec.2008.05.004
2008
Craig SJ; Shu A; Xu Y; Foong F; Nordon RE, 2007, 'Chimeric protein for selective cell attachment onto cellulosic substrates', Protein Engineering Design and Selection, vol. 20, pp. 235 - 241, http://dx.doi.org/10.1093/protein/gzm016
2007
Conference Abstracts
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Munier CML; Bailey M; Ip S; Xu Y; Alcantara S; Liu SM; van Bockel D; Suzuki K; Cooper DA; Kent SJ; Zaunders JJ; Kelleher AD, 2016, 'The primary immune response to vaccinia virus vaccination includes cells with a distinct cytotoxic effector CD4 T cell phenotype', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Melbourne, AUSTRALIA, Vol. 46, pp. 676 - 677, presented at International Congress of Immunology (ICI), Melbourne, AUSTRALIA, 21 August 2016 - 26 August 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610401550&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2016
Xu Y; Bailey M; Phetsouphanh C; Harvey R; Turville S; Aggarwal A; Wong A; Suzuki K; Graff-Dubois S; Autran B; Moris A; Munier ML; Koelsch K; Kent S; Zaunders J; Kelleher A, 2016, 'Accumulation of follicular T Helper (Tfh) cells, despite preferential infection, allows establishment of a large and unexpected viral reservoir during HIV infection', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Melbourne, AUSTRALIA, Vol. 46, pp. 264 - 264, presented at International Congress of Immunology (ICI), Melbourne, AUSTRALIA, 21 August 2016 - 26 August 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610400533&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2016
Conference Papers
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Koelsch KK; Xu Y; Bailey M; McBride K; Seddiki N; Suzuki K; Murray J; Cooper DA; Kelleher AD; Zaunders J, 2010, 'Most HIV DNA in PBMC is present in non-gut-homing, resting central memory CD4 T-cells.', in ANTIVIRAL THERAPY, INT MEDICAL PRESS LTD, Dubrovnik, CROATIA, pp. A44 - A44, presented at International HIV and Hepatitis Virus Drug Resistance and Curative Strategies Workshop, Dubrovnik, CROATIA, 08 June 2010 - 12 June 2010, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000280215800055&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2010
Koelsch KK; Xu Y; Bailey M; McBride K; Seddiki N; Suzuki K; Murray J; Cooper DA; Kelleher AD; Zaunders J, 2010, 'Most HIV DNA in PBMC is present in non-gut-homing, resting central memory CD4 T-cells', in ANTIVIRAL THERAPY, INT MEDICAL PRESS LTD, Dubrovnik, CROATIA, pp. A44 - A44, presented at International HIV and Hepatitis Virus Drug Resistance and Curative Strategies Workshop, Dubrovnik, CROATIA, 08 June 2010 - 12 June 2010, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000287431300040&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2010