Simon Brayford

Research Officer, Children's Cancer Institute
Consultancies and Vendor Staff

Dr Simon Brayford is a researcher at the Children's Cancer Institute and UNSW Conjoint Lecturer. His research interests include cell-signalling, metastasis and understanding mechanisms contributing to chemotherapy resistance in tumours. The aim of this research is to develop novel, multi-targeted therapeutic strategies for a range of adult and childhood cancers.

publications

Journal articles
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Cagigas ML; Bryce NS; Ariotti N; Brayford S; Gunning PW; Hardeman EC, 2022, 'Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell–substrate adhesion in cancer cells and mechanosensitivity of cell proliferation', Nature Materials, vol. 21, pp. 120 - 128, http://dx.doi.org/10.1038/s41563-021-01087-z
2022
Law AL; Jalal S; Pallett T; Mosis F; Guni A; Brayford S; Yolland L; Marcotti S; Levitt JA; Poland SP; Rowe-Sampson M; Jandke A; Köchl R; Pula G; Ameer-Beg SM; Stramer BM; Krause M, 2021, 'Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration', Nature Communications, vol. 12, pp. 5687, http://dx.doi.org/10.1038/s41467-021-25916-6
2021
Brayford S; Kenny FN; Hiratsuka T; Serna-Morales E; Yolland L; Luchici A; Stramer BM, 2019, 'Heterotypic contact inhibition of locomotion can drive cell sorting between epithelial and mesenchymal cell populations', Journal of Cell Science, vol. 132, http://dx.doi.org/10.1242/jcs.223974
2019
Brayford S; Bryce NS; Schevzov G; Haynes EM; Bear JE; Hardeman EC; Gunning PW, 2016, 'Tropomyosin promotes lamellipodial persistence by collaborating with Arp2/3 at the leading edge', Current Biology, vol. 26, pp. 1312 - 1318, http://dx.doi.org/10.1016/j.cub.2016.03.028
2016
Conference Presentations
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Brayford S, 2018, 'EphB2 acts via ERK signalling to promote active cell repulsion and cell sorting', presented at The Dynamic Cell III, Manchester Conference Centre, Manchester, UK, 19 March 2018 - 21 March 2018, https://www.eventsforce.net/biochemsoc/frontend/reg/absViewDocumentFE.csp?popup=1&documentID=298&eventID=17
2018
Brayford S; Schevzov G; Hardeman EC; Bear JE; Gunning PW, 2014, 'Tropomyosin 5a/b actin filaments collaborate with arp2/3 actin filaments to regulate cell motility.', Vol. 25, presented at ASCB/IFCB Meeting, Philadelphia, PA, 06 December 2014 - 10 December 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352094100083&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2014
Book Chapters
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Brayford S; Schevzov G; Vos J; Gunning P, 2015, 'The role of the actin cytoskeleton in cancer and its potential use as a therapeutic target', in The Cytoskeleton in Health and Disease, pp. 373 - 391, http://dx.doi.org/10.1007/978-1-4939-2904-7_16
2015
Preprints
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Law A-L; Jalal S; Pallett T; Mosis F; Guni A; Brayford S; Yolland L; Marcotti S; Levitt JA; Poland SP; Rowe-Sampson M; Jandke A; Köchl R; Pula G; Ameer-Beg SM; Stramer BM; Krause M, Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration, http://dx.doi.org/10.1101/2020.05.11.083030
Brayford S; Serna-Morales E; Luchici A; Hiratsuka T; Stramer BM, EphB2 and ERK signaling are required for heterotypic contact inhibition of locomotion to drive cell sorting, http://dx.doi.org/10.1101/373696