Nicholas Shackel

Professor of Medicine
Professor

Nick Shackel is Professor of Medicine at UNSW and Liverpool Hospital. The research group he leads is based at the Ingham Institute at Liverpool Hospital.

Current Position

Prof. Shackel is UNSW Academic and a Senior Clinician within the Gastroenterology Department at Liverpool Hospital. He is also a PhD Scientist and Head of the Gastroenterology and Liver Disease group at the Ingham Institute. Prof Shackels’ laboratory research uses functional genomics to better understand liver inflammation, fibrosis, cirrhosis and cancer as well as using transgenic animals to model human liver disease. Clinical research undertaken by his group examines the use of probiotics to change the composition of the gut flora, treatment of muscle cramps, the use biomarker predictors of liver injury and nutritional interventions in end stage liver disease. Currently Prof. Shackel leads a group of eight researchers and in August 2016 become a Professor of Medicine at UNSW and Professor of Gastroenterology at Liverpool Hospital Sydney, which is the largest hospital in Australia.

Prof. Shackel leads a group of engaged researchers whom are enthusiastic and pursue the highest possible academic standards. Prof. Shackel encourages directed independent learning and respect in research. Prof. Shackel supervises science, medicine and allied health graduates (including dieticians and nurses). Students find working with Prof. Shackel rewarding and challenging and to date he has supervised 5 honours students (4 with University Medals), 1 Masters and 7 PhD students. 

Current Funding

Prof. Shackel has NHMRC project grant funding and is the recipient of multiple other competitive grants as well pharmaceutical industry collaborative funding.

Publications

Journal articles
add
Sasadeusz J; Grigg A; Hughes PD; Lim SL; Lucas M; McColl G; McLachlan SA; Peters MG; Shackel N; Slavin M; Sundararajan V; Thompson A; Doyle J; Rickard J; De Cruz P; Gish RG; Visvanathan K, 2019, 'Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Patients with Hematological and Solid Tumor Malignancies', Clinics in Liver Disease, vol. 23, pp. 511 - 519, http://dx.doi.org/10.1016/j.cld.2019.04.011
2019
d’Avigdor WMH; Budzinska MA; Lee M; Lam R; Kench J; Stapelberg M; McLennan SV; Farrell G; George J; McCaughan GW; Tu T; Shackel NA, 2019, 'Virus Genotype-Dependent Transcriptional Alterations in Lipid Metabolism and Inflammation Pathways in the Hepatitis C Virus-infected Liver', Scientific Reports, vol. 9, http://dx.doi.org/10.1038/s41598-019-46664-0
2019
Sasadeusz J; Grigg A; Hughes PD; Lee Lim S; Lucas M; McColl G; McLachlan SA; Peters MG; Shackel N; Slavin M; Sundararajan V; Thompson A; Doyle J; Rickard J; De Cruz P; Gish RG; Visvanathan K, 2019, 'Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Introduction and Immunology', Clinics in Liver Disease, vol. 23, pp. 487 - 492, http://dx.doi.org/10.1016/j.cld.2019.04.009
2019
Sasadeusz J; Grigg A; Hughes PD; Lee Lim S; Lucas M; McColl G; McLachlan SA; Peters MG; Shackel N; Slavin M; Sundararajan V; Thompson A; Doyle J; Rickard J; De Cruz P; Gish RG; Visvanathan K, 2019, 'Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Transplant Recipients', Clinics in Liver Disease, vol. 23, pp. 493 - 509, http://dx.doi.org/10.1016/j.cld.2019.04.010
2019
Yee C; Main NM; Terry A; Stevanovski I; Maczurek A; Morgan AJ; Calabro S; Potter AJ; Iemma TL; Bowen DG; Ahlenstiel G; Warner FJ; McCaughan GW; McLennan SV; Shackel NA, 2019, 'CD147 mediates intrahepatic leukocyte aggregation and determines the extent of liver injury', PLoS ONE, vol. 14, http://dx.doi.org/10.1371/journal.pone.0215557
2019
Vidot H; Cvejic E; Finegan LJ; Shores EA; Bowen DG; Strasser SI; McCaughan GW; Carey S; Allman-Farinelli M; Shackel NA, 2019, 'Supplementation with synbiotics and/or branched chain amino acids in hepatic encephalopathy: A pilot randomised placebo-controlled clinical study', Nutrients, vol. 11, http://dx.doi.org/10.3390/nu11081810
2019
Vidot H; Kline K; Cheng R; Finegan L; Lin A; Kempler E; Strasser SI; Bowen DG; McCaughan G; Carey S; Allman-Farinelli M; Shackel NA, 2019, 'The relationship of obesity, nutritional status and musclewasting in patients assessed for liver transplantation', Nutrients, vol. 11, http://dx.doi.org/10.3390/nu11092097
2019
Sasadeusz J; Grigg A; Hughes PD; Lee Lim S; Lucas M; McColl G; McLachlan SA; Peters MG; Shackel N; Slavin M; Sundararajan V; Thompson A; Doyle J; Rickard J; De Cruz P; Gish RG; Visvanathan K, 2019, 'Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Other Populations and Newer Agents', Clinics in Liver Disease, vol. 23, pp. 521 - 534, http://dx.doi.org/10.1016/j.cld.2019.04.012
2019
Pulitano C; Ho P; Verran D; Sandroussi C; Joseph D; Bowen DG; McCaughan GW; Crawford M; Shackel N, 2018, 'Molecular profiling of postreperfusion milieu determines acute kidney injury after liver transplantation: A prospective study', Liver Transplantation, vol. 24, pp. 922 - 931, http://dx.doi.org/10.1002/lt.25178
2018
Budzinska MA; Shackel NA; Urban S; Tu T, 2018, 'Sequence analysis of integrated hepatitis B virus DNA during HBeAg-seroconversion', Emerging Microbes and Infections, vol. 7, http://dx.doi.org/10.1038/s41426-018-0145-7
2018
Waller KMJ; Wyburn KR; Shackel NA; O'Leary MJ; Kelly PJ; Webster AC, 2018, 'Hepatitis Transmission Risk in Kidney Transplantation (the HINT study): A Cross-Sectional Survey of Transplant Clinicians in Australia and New Zealand', Transplantation, vol. 102, pp. 146 - 153, http://dx.doi.org/10.1097/TP.0000000000001885
2018
Lomax AJ; Lim J; Cheng R; Sweeting A; Lowe P; McGill N; Shackel N; Chua EL; McNeil C, 2018, 'Immune Toxicity with Checkpoint Inhibition for Metastatic Melanoma: Case Series and Clinical Management', Journal of Skin Cancer, vol. 2018, http://dx.doi.org/10.1155/2018/9602540
2018
Menon V; Davis R; Shackel N; Espedido BA; Beukers AG; Jensen SO; van Hal SJ, 2018, 'Failure of daptomycin β-Lactam combination therapy to prevent resistance emergence in Enterococcus faecium', Diagnostic Microbiology and Infectious Disease, vol. 90, pp. 120 - 122, http://dx.doi.org/10.1016/j.diagmicrobio.2017.10.017
2018
Vidot H; Cvejic E; Carey S; Strasser SI; McCaughan GW; Allman-Farinelli M; Shackel NA, 2018, 'Randomised clinical trial: oral taurine supplementation versus placebo reduces muscle cramps in patients with chronic liver disease', Alimentary Pharmacology and Therapeutics, vol. 48, pp. 704 - 712, http://dx.doi.org/10.1111/apt.14950
2018
Thilakanathan C; Wark G; Maley M; Davison S; Lawler J; Lee A; Shackel N; Nguyen V; Jackson K; Glass A; Locarnini SA; Levy MT, 2018, 'Mother-to-child transmission of hepatitis B: Examining viral cut-offs, maternal HBsAg serology and infant testing', Liver International, vol. 38, pp. 1212 - 1219, http://dx.doi.org/10.1111/liv.13736
2018
Tu T; Budzinska MA; Vondran FWR; Shackel NA; Urban S, 2018, 'Hepatitis B virus DNA integration occurs early in the viral life cycle in an in vitro infection model via sodium taurocholate cotransporting polypeptidedependent uptake of enveloped virus particles', Journal of Virology, vol. 92, http://dx.doi.org/10.1128/JVI.02007-17
2018
Budzinska MA; Shackel NA; Urban S; Tu T, 2018, 'Cellular genomic sites of hepatitis B virus DNA integration', Genes, vol. 9, http://dx.doi.org/10.3390/genes9070365
2018
Thilakanathan C; Wark G; Maley MW; Davison S; Lee A; Glass A; Shackel N; Nguyen V; Jackson KM; Lawler J; Locarnini SA; Levy MT, 2017, 'Can quantitative HBsAg threshold predict high viral load and risk of mother-to-child transmission? Like life, you get what you pay for', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY, pp. 82 - 82, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000407897100151&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2017
Vidot H; Bowen DG; Carey S; McCaughan GW; Allman-Farinelli M; Shackel NA, 2017, 'Aggressive nutrition intervention reduces ascites and frequency of paracentesis in malnourished patients with cirrhosis and ascites', JGH Open, vol. 1, pp. 92 - 97, http://dx.doi.org/10.1002/jgh3.12016
2017
Navani V; Chan P; Borchard J; Ladera A; Coppock J; Turner I; Shackel N; Levy M; Davison S; Prakoso E, 2017, 'Effect of direct-acting antivirals on hepatocellular carcinoma incidence in hepatitis C virus-related cirrhosis', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY, pp. 75 - 75, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000407897100139&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2017
Thilakanathan C; Wark G; Maley M; Davison S; Lee A; Glass AL; Shackel NA; Nguyen V; Jackson K; Lawler J; Locarnini S; Levy M, 2017, 'Can Quantitative HBsAg Threshold Predict High Viral Load and Risk of Mother to Child Transmission? Like Life, You Get What You Pay For', in HEPATOLOGY, WILEY, Washington, DC, pp. 1009A - 1010A, presented at 68th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Washington, DC, 20 October 2017 - 24 October 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000412089802260&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2017
Mohsen W; Rodov M; Prakoso E; Charlton B; Bowen DG; Koorey DJ; Shackel NA; McCaughan GW; Strasser SI, 2017, 'Patients with non-viral liver disease have a greater tumor burden and less curative treatment options when diagnosed with hepatocellular carcinoma', World Journal of Gastroenterology, vol. 23, pp. 2763 - 2770, http://dx.doi.org/10.3748/wjg.v23.i15.2763
2017
Tu T; Patel K; Shackel NA, 2017, 'Viral Hepatitis', in Genomic and Precision Medicine: Primary Care: Third Edition, pp. 317 - 340, http://dx.doi.org/10.1016/B978-0-12-800685-6.00017-5
2017
Tu T; Budzinska MA; Shackel NA; Urban S, 2017, 'HBV DNA integration: Molecular mechanisms and clinical implications', Viruses, vol. 9, http://dx.doi.org/10.3390/v9040075
2017
Grzelak CA; Sigglekow ND; Tirnitz-Parker JEE; Hamson EJ; Warren A; Maneck B; Chen J; Patkunanathan B; Boland J; Cheng R; Shackel NA; Seth D; Bowen DG; Martelotto LG; Watkins DN; McCaughan GW, 2017, 'Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease', PLoS ONE, vol. 12, http://dx.doi.org/10.1371/journal.pone.0171480
2017
Pulitano C; Joseph D; Sandroussi C; Verran D; Ho P; Debiasio A; Luongo A; McCaughan GW; Shackel NA; Crawford M, 2017, 'Postreperfusion microcirculatory derangements after liver transplantation: Relationship to hemodynamics, serum mediators, and outcome', Liver Transplantation, vol. 23, pp. 527 - 536, http://dx.doi.org/10.1002/lt.24721
2017
Vidot H; Potter A; Cheng R; Allman-Farinelli M; Shackel N, 2017, 'Serum 25-hydroxyvitamin D deficiency and hepatic encephalopathy in chronic liver disease', World Journal of Hepatology, vol. 9, pp. 510 - 518, http://dx.doi.org/10.4254/wjh.v9.i10.510
2017
Tong A; Sautenet B; Chapman JR; Harper C; MacDonald P; Shackel N; Crowe S; Hanson C; Hill S; Synnot A; Craig JC, 2017, 'Research priority setting in organ transplantation: a systematic review', Transplant International, vol. 30, pp. 327 - 343, http://dx.doi.org/10.1111/tri.12924
2017
Vidot H; Teevan K; Carey S; Strasser S; Shackel N, 2016, 'A prospective audit of preprocedural fasting practices on a transplant ward: When fasting becomes starving', Journal of Clinical Nursing, vol. 25, pp. 829 - 835, http://dx.doi.org/10.1111/jocn.13116
2016
Ban LA; Shackel NA; McLennan SV, 2016, 'Extracellular vesicles: A new frontier in biomarker discovery for non-alcoholic fatty liver disease', International Journal of Molecular Sciences, vol. 17, http://dx.doi.org/10.3390/ijms17030376
2016
Budzinska MA; Tu T; D'avigdo WMH; Mccaughan GW; Luciani F; Shackel NA, 2016, 'Accumulation of deleterious passenger mutations is associated with the progression of hepatocellular carcinoma', in PLoS ONE, Vol. 11, http://dx.doi.org/10.1371/journal.pone.0162586
2016
Mccaughan GW; Crawford M; Sandroussi C; Koorey DJ; Bowen DG; Shackel NA; Strasser SI, 2016, 'Assessment of adult patients with chronic liver failure for liver transplantation in 2015: Who and when?', Internal Medicine Journal, vol. 46, pp. 404 - 412, http://dx.doi.org/10.1111/imj.13025
2016
Lee A; Rode A; Nicoll A; Maczurek AE; Lim L; Lim S; Angus P; Kronborg I; Arachchi N; Gorelik A; Liew D; Warner FJ; Mccaughan GW; Mclennan SV; Shackel NA, 2016, 'Circulating CD147 predicts mortality in advanced hepatocellular carcinoma', Journal of Gastroenterology and Hepatology (Australia), vol. 31, pp. 459 - 466, http://dx.doi.org/10.1111/jgh.13148
2016
Adams LA; Arauz O; Angus PW; Sinclair M; Macdonald GA; Chelvaratnam U; Wigg AJ; Yeap S; Shackel N; Lin L; Raftopoulos S; Mccaughan GW; Jeffrey GP; Delriviere L; Lynch S; Jones R; Munn S; Padbury R, 2016, 'Additive impact of pre-liver transplant metabolic factors on survival post-liver transplant', Journal of Gastroenterology and Hepatology (Australia), vol. 31, pp. 1016 - 1024, http://dx.doi.org/10.1111/jgh.13240
2016
Patel K; Tillmann HL; Matta B; Sheridan MJ; Gardner SD; Shackel NA; McHutchison JG; Goodman ZD, 2016, 'Longitudinal assessment of hepatitis C fibrosis progression by collagen and smooth muscle actin morphometry in comparison to serum markers', Alimentary Pharmacology and Therapeutics, vol. 43, pp. 356 - 363, http://dx.doi.org/10.1111/apt.13471
2016
Budzinska MA; Tu T; d'Avigdor WMH; McCaughan GW; Luciani F; Shackel NA, 2016, 'Accumulation of Deleterious Passenger Mutations Is Associated with the Progression of Hepatocellular Carcinoma.', PLoS One, vol. 11, pp. e0162586, http://dx.doi.org/10.1371/journal.pone.0162586
2016
Köhn-Gaone J; Dwyer BJ; Grzelak CA; Miller G; Shackel NA; Ramm GA; McCaughan GW; Elsegood CL; Olynyk JK; Tirnitz-Parker JEE, 2016, 'Divergent Inflammatory, Fibrogenic, and Liver Progenitor Cell Dynamics in Two Common Mouse Models of Chronic Liver Injury', American Journal of Pathology, vol. 186, pp. 1762 - 1774, http://dx.doi.org/10.1016/j.ajpath.2016.03.005
2016
Pulitano C; Joseph D; Sroussi C; Verran D; Strasser SI; Shackel NA; McCaughan GW; Crawford M, 2015, 'Hepatic artery stenosis after liver transplantation: Is endovascular treatment always necessary?', Liver Transplantation, vol. 21, pp. 162 - 168, http://dx.doi.org/10.1002/lt.24043
2015
Tu T; Calabro SR; Lee A; Maczurek AE; Budzinska MA; Warner FJ; Mclennan SV; Shackel NA, 2015, 'Hepatocytes in liver injury: Victim, bystander, or accomplice in progressive fibrosis?', Journal of Gastroenterology and Hepatology (Australia), vol. 30, pp. 1696 - 1704, http://dx.doi.org/10.1111/jgh.13065
2015
Brockhausen J; Tay SS; Grzelak CA; Bertolino P; Bowen DG; d'Avigdor WM; Teoh N; Pok S; Shackel N; Gamble JR; Vadas M; Mccaughan GW, 2015, 'miR-181a mediates TGF-β-induced hepatocyte EMT and is dysregulated in cirrhosis and hepatocellular cancer', Liver International, vol. 35, pp. 240 - 253, http://dx.doi.org/10.1111/liv.12517
2015
Williams KH; Vieira De Ribeiro AJ; Prakoso E; Veillard AS; Shackel NA; Brooks B; Bu Y; Cavanagh E; Raleigh J; Mclennan SV; Mccaughan GW; Keane FM; Zekry A; Gorrell MD; Twigg SM, 2015, 'Circulating dipeptidyl peptidase-4 activity correlates with measures of hepatocyte apoptosis and fibrosis in non-alcoholic fatty liver disease in type 2 diabetes mellitus and obesity: A dual cohort cross-sectional study', Journal of Diabetes, vol. 7, pp. 809 - 819, http://dx.doi.org/10.1111/1753-0407.12237
2015
Rahman W; Tu T; Budzinska M; Huang P; Belov L; Chrisp JS; Christopherson RI; Warner FJ; Bowden DS; Thompson AJ; Bowen DG; Strasser SI; Koorey D; Sharland AF; Yang JYH; McCaughan GW; Shackel NA, 2015, 'Analysis of Post-Liver Transplant Hepatitis C Virus Recurrence Using Serial Cluster of Differentiation Antibody Microarrays', Transplantation, vol. 99, pp. e120 - e126, http://dx.doi.org/10.1097/TP.0000000000000617
2015
Williams KH; Burns K; Constantino M; Shackel NA; Prakoso E; Wong J; Wu T; George J; McCaughan GW; Twigg SM, 2015, 'An association of large-fibre peripheral nerve dysfunction with non-invasive measures of liver fibrosis secondary to non-alcoholic fatty liver disease in diabetes', Journal of Diabetes and its Complications, vol. 29, pp. 1240 - 1247, http://dx.doi.org/10.1016/j.jdiacomp.2015.06.015
2015
Williams KH; Viera de Ribeiro AJ; Prakoso E; Veillard AS; Shackel NA; Bu Y; Brooks B; Cavanagh E; Raleigh J; McLennan SV; McCaughan GW; Bachovchin WW; Keane FM; Zekry A; Twigg SM; Gorrell MD, 2015, 'Lower serum fibroblast activation protein shows promise in the exclusion of clinically significant liver fibrosis due to non-alcoholic fatty liver disease in diabetes and obesity', Diabetes Research and Clinical Practice, vol. 108, pp. 466 - 472, http://dx.doi.org/10.1016/j.diabres.2015.02.024
2015
Tu T; Budzinska MA; Shackel NA; Jilbert AR, 2015, 'Conceptual models for the initiation of hepatitis B virus-associated hepatocellular carcinoma', Liver International, vol. 35, pp. 1786 - 1800, http://dx.doi.org/10.1111/liv.12773
2015
Tu T; Mason WS; Clouston AD; Shackel NA; McCaughan GW; Yeh MM; Schiff ER; Ruszkiewicz AR; Chen JW; Harley HAJ; Stroeher UH; Jilbert AR, 2015, 'Clonal expansion of hepatocytes with a selective advantage occurs during all stages of chronic hepatitis B virus infection', Journal of Viral Hepatitis, vol. 22, pp. 737 - 753, http://dx.doi.org/10.1111/jvh.12380
2015
Cheng R; Cooper A; Kench J; Watson G; Bye W; Mcneil C; Shackel N, 2015, 'Ipilimumab-induced toxicities and the gastroenterologist', Journal of Gastroenterology and Hepatology (Australia), vol. 30, pp. 657 - 666, http://dx.doi.org/10.1111/jgh.12888
2015
Calabro SR; Maczurek AE; Morgan AJ; Tu T; Wen VW; Yee C; Mridha A; Lee M; D'Avigdor W; Locarnini SA; McCaughan GW; Warner FJ; McLennan SV; Shackel NA, 2014, 'Hepatocyte produced matrix metalloproteinases are regulated by CD147 in liver fibrogenesis', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0090571
2014
Young JA; Ting KK; Li J; Moller T; Dunn L; Lu Y; Lay AJ; Moses J; Prado-Lourenço L; Khachigian LM; Ng M; Gregory PA; Goodall GJ; Tsykin A; Lichtenstein I; Hahn CN; Tran N; Shackel N; Kench JG; McCaughan G; Vadas MA; Gamble JR, 2014, 'Erratum: Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted mirna antagonists of mir-27 (Blood (2012) 122:16 (2911-2919))', Blood, vol. 124, pp. 3034, http://dx.doi.org/10.1182/blood-2014-09-604066
2014
Prakoso E; Tirnitz-Parker JEE; Clouston AD; Kayali Z; Lee A; Gan EK; Ramm GA; Kench JG; Bowen DG; Olynyk JK; McCaughan GW; Shackel NA, 2014, 'Analysis of the intrahepatic ductular reaction and progenitor cell responses in hepatitis C virus recurrence after liver transplantation', Liver Transplantation, vol. 20, pp. 1508 - 1519, http://dx.doi.org/10.1002/lt.24007
2014
Grzelak CA; Martelotto LG; Sigglekow ND; Patkunanathan B; Ajami K; Calabro SR; Dwyer BJ; Tirnitz-Parker JEE; Watkins DN; Warner FJ; Shackel NA; McCaughan GW, 2014, 'The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury', Journal of Hepatology, vol. 60, pp. 143 - 151, http://dx.doi.org/10.1016/j.jhep.2013.08.012
2014
Tu T; Budzinska MA; Maczurek AE; Cheng R; Di Bartolomeo A; Warner FJ; McCaughan GW; McLennan SV; Shackel NA, 2014, 'Novel aspects of the liver microenvironment in hepatocellular carcinoma pathogenesis and development', International Journal of Molecular Sciences, vol. 15, pp. 9422 - 9458, http://dx.doi.org/10.3390/ijms15069422
2014
Beard MR; Ffrench R; Gowans EJ; Helbig KJ; Eyre NM; Douglas MMW; Grebely J; Ahlenstiel G; Locarnini S; George J; Shackel NA; White PA; Thompson AJ; Drummer HE, 2014, 'A Summary of the 20th International Symposium on Hepatitis C Virus and Related Viruses', in Gastroenterology, pp. e1 - e4, http://dx.doi.org/10.1053/j.gastro.2014.05.022
2014
Shackel NA; Vadas MA; Gamble JR; Mccaughan GW, 2014, 'Beyond liver fibrosis: Hepatic stellate cell senescence links obesity to liver cancer by way of the microbiome', Hepatology, vol. 59, pp. 2413 - 2415, http://dx.doi.org/10.1002/hep.26932
2014
Farrell GC; Mridha AR; Yeh MM; Arsov T; Van Rooyen DM; Brooling J; Nguyen T; Heydet D; Delghingaro-Augusto V; Nolan CJ; Shackel NA; Mclennan SV; Teoh NC; Larter CZ, 2014, 'Strain dependence of diet-induced NASH and liver fibrosis in obese mice is linked to diabetes and inflammatory phenotype', Liver International, vol. 34, pp. 1084 - 1093, http://dx.doi.org/10.1111/liv.12335
2014
Cheng R; Tu T; Shackel N; Mccaughan GW, 2014, 'Advances in and the future of treatments for hepatitis C', Expert Review of Gastroenterology and Hepatology, vol. 8, pp. 633 - 647, http://dx.doi.org/10.1586/17474124.2014.909725
2014
Vidot H; Carey S; Allman-Farinelli M; Shackel N, 2014, 'Systematic review: The treatment of muscle cramps in patients with cirrhosis', Alimentary Pharmacology and Therapeutics, vol. 40, pp. 221 - 232, http://dx.doi.org/10.1111/apt.12827
2014
Patel K; Shackel NA, 2014, 'Current status of fibrosis markers', Current Opinion in Gastroenterology, vol. 30, pp. 253 - 259, http://dx.doi.org/10.1097/MOG.0000000000000059
2014
Young JA; Ting KK; Li J; Moller T; Dunn L; Lu Y; Lay AJ; Moses J; Prado-Lourenço L; Khachigian LM; Ng M; Gregory PA; Goodall GJ; Tsykin A; Lichtenstein I; Hahn CN; Tran N; Shackel N; Kench JG; McCaughan G; Vadas MA; Gamble JR, 2013, 'Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27', Blood, vol. 122, pp. 2911 - 2919, http://dx.doi.org/10.1182/blood-2012-12-473017
2013
Prakoso E; Jones C; Koorey DJ; Strasser SI; Bowen D; Mccaughan GW; Shackel NA, 2013, 'Author reply', Internal Medicine Journal, vol. 43, pp. 607 - 607, http://dx.doi.org/10.1111/imj.12114
2013
Williams KH; Shackel NA; Gorrell MD; McLennan SV; Twigg SM, 2013, 'Diabetes and nonalcoholic fatty liver disease: A pathogenic duo', Endocrine Reviews, vol. 34, pp. 84 - 129, http://dx.doi.org/10.1210/er.2012-1009
2013
Chung SH; Shen W; Jayawardana K; Wang P; Yang J; Shackel N; Gillies MC, 2013, 'Differential gene expression profiling after conditional müller-cell ablation in a novel transgenic model', Investigative Ophthalmology and Visual Science, vol. 54, pp. 2142 - 2152, http://dx.doi.org/10.1167/iovs.12-11559
2013
Prakoso E; Jones C; Koorey DJ; Strasser SI; Bowen D; McCaughan GW; Shackel NA, 2013, 'Terlipressin therapy for moderate-to-severe hyponatraemia in patients with liver failure', Internal Medicine Journal, vol. 43, pp. 240 - 246, http://dx.doi.org/10.1111/imj.12032
2013
Shackel NA; Patel K; McHutchison J, 2013, 'Viral Hepatitis', in Genomic and Personalized Medicine, pp. 1173 - 1190, http://dx.doi.org/10.1016/B978-0-12-382227-7.00099-9
2013
Shackel NA; Patel K; McHutchison J, 2013, 'Cirrhosis', in Genomic and Personalized Medicine, pp. 935 - 954, http://dx.doi.org/10.1016/B978-0-12-382227-7.00078-1
2013
Bowen DG; Shackel NA, 2013, 'Hepatitis C pathogenesis and outcomes after liver transplantation: Probing microRNA expression for new insights', Liver Transplantation, vol. 19, pp. 355 - 357, http://dx.doi.org/10.1002/lt.23625
2013
Perera NJ; Steinbeck KS; Shackel N, 2013, 'The adverse health consequences of the use of multiple performance- enhancing substances-a deadly cocktail', Journal of Clinical Endocrinology and Metabolism, vol. 98, pp. 4613 - 4618, http://dx.doi.org/10.1210/jc.2013-2310
2013
McLennan SV; Warner FJ; Shackel NA, 2013, 'The role of CD147 in liver injury: "The truth is in the details"', Journal of Hepatology, vol. 58, pp. 836 - 837, http://dx.doi.org/10.1016/j.jhep.2012.11.029
2013
Tu T; Shackel NA; McCaughan G, 2013, '"Testing your methyl": DNA methylation profiling of serum DNA of HCC patients', Hepatology International, vol. 7, pp. 785 - 787, http://dx.doi.org/10.1007/s12072-013-9444-1
2013
Mohsen W; Rodov M; Prakoso E; Bowen D; Koorey DJ; Shackel NA; McCaughan GW; Strasser SI, 2013, 'Presenting Features and Outcomes of Hepatocellular Carcinoma Are Worse in Patients With Non-Viral Liver Disease', in GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, Orlando, FL, pp. S959 - S959, presented at Digestive Disease Week / 28th Annual Residents and Fellows Research Conference of the Society-for-Surgery-of-the-Alimentary-Tract (SSAT), Orlando, FL, 18 May 2013 - 21 May 2013, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000322997205412&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2013
Pok S; Wen V; Shackel N; Alsop A; Pyakurel P; Fahrer A; Farrell GC; Teoh NC, 2013, 'Cyclin E facilitates dysplastic hepatocytes to bypass G1/S checkpoint in hepatocarcinogenesis', Journal of Gastroenterology and Hepatology (Australia), vol. 28, pp. 1545 - 1554, http://dx.doi.org/10.1111/jgh.12216
2013
de Graaf EL; Kench J; Dilworth P; Shackel NA; Strasser SI; Joseph D; Pleass H; Crawford M; Mccaughan GW; Verran DJ, 2012, 'Grade of deceased donor liver macrovesicular steatosis impacts graft and recipient outcomes more than the Donor Risk Index', Journal of Gastroenterology and Hepatology (Australia), vol. 27, pp. 540 - 546, http://dx.doi.org/10.1111/j.1440-1746.2011.06844.x
2012
Shackel NA, 2012, 'When has the horse bolted?', Journal of Gastroenterology and Hepatology (Australia), vol. 27, pp. 1133 - 1134, http://dx.doi.org/10.1111/j.1440-1746.2012.07164.x
2012
Shackel NA, 2012, 'Looking into Pandora's box', Liver Transplantation, vol. 18, pp. 274 - 276, http://dx.doi.org/10.1002/lt.23375
2012
Rahman W; Huang P; Belov L; Chrisp JS; Christopherson RI; Stapelberg PM; Warner FJ; George J; Bowen DG; Strasser SI; Koorey D; Sharland AF; Mccaughan GW; Shackel NA, 2012, 'Analysis of human liver disease using a cluster of differentiation (CD) antibody microarray', Liver International, vol. 32, pp. 1527 - 1534, http://dx.doi.org/10.1111/j.1478-3231.2012.02854.x
2012
Tan SY; Cavanagh LL; D'Advigor W; Shackel N; De St Groth BF; Weninger W, 2012, 'Phenotype and functions of conventional dendritic cells are not compromised in aged mice', Immunology and Cell Biology, vol. 90, pp. 722 - 732, http://dx.doi.org/10.1038/icb.2011.104
2012
Song S; Shackel NA; Wang XM; Ajami K; McCaughan GW; Gorrell MD, 2011, 'Discoidin domain receptor 1: Isoform expression and potential functions in cirrhotic human liver', American Journal of Pathology, vol. 178, pp. 1134 - 1144, http://dx.doi.org/10.1016/j.ajpath.2010.11.068
2011
McCaughan GW; Shackel NA; Bowen DG, 2011, 'Liver transplantation and hepatitis C: Will understanding the interleukin-28B polymorphisms improve outcomes?', Liver Transplantation, vol. 17, pp. 219 - 221, http://dx.doi.org/10.1002/lt.22252
2011
Prakoso E; Bowen D; Kench JG; Clouston AD; McCaughan GW; Shackel NA, 2011, 'Immunophenotype of Ductular Reaction in Human Livers With HCV', in GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, Chicago, IL, pp. S972 - S972, presented at Conference on Digestive Disease Week 2011, Chicago, IL, 07 May 2011 - 10 May 2011, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000290167304482&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2011
Shackel NA; Patel K; McHutchison J, 2010, 'Genomics in Pathogenesis of Cirrhosis', in Essentials of Genomic and Personalized Medicine, pp. 645 - 660, http://dx.doi.org/10.1016/B978-0-12-374934-5.00050-7
2010
Shackel NA; Patel K; McHutchison J, 2010, 'Genomics and the Management of Hepatitis', in Essentials of Genomic and Personalized Medicine, pp. 774 - 785, http://dx.doi.org/10.1016/B978-0-12-374934-5.00060-X
2010
Shackel NA, 2010, 'The balancing act of hepatocyte apoptosis', Hepatology, vol. 52, pp. 2231 - 2233, http://dx.doi.org/10.1002/hep.24007
2010
Prakoso E; Verran D; Dilworth P; Kyd G; Tang P; Tse C; Koorey DJ; Strasser SI; Stormon M; Shun A; Thomas G; Joseph D; Pleass H; Gallagher J; Allen R; Crawford M; McCaughan GW; Shackel NA, 2010, 'Increasing liver transplantation waiting list mortality: A report from the Australian National Liver Transplantation Unit, Sydney', Internal Medicine Journal, vol. 40, pp. 619 - 625, http://dx.doi.org/10.1111/j.1445-5994.2010.02277.x
2010
McCaughan GW; Shackel NA; Strasser SI; Dilworth P; Tang P, 2010, 'Minimal but significant improvement in survival for non-hepatitis C-related adult liver transplant patients beyond the one-year posttransplant mark', Liver Transplantation, vol. 16, pp. 130 - 137, http://dx.doi.org/10.1002/lt.21978
2010
Shackel NA; Bowen DG; McCaughan GW, 2010, 'Snipping away at hepatitis C comment', Hepatology, vol. 51, pp. 703 - 705, http://dx.doi.org/10.1002/hep.23490
2010
Bao W; Min D; Twigg SM; Shackel NA; Warner FJ; Yue DK; McLennan SV, 2010, 'Monocyte CD147 is induced by advanced glycation end products and high glucose concentration: Possible role in diabetic complications', American Journal of Physiology - Cell Physiology, vol. 299, http://dx.doi.org/10.1152/ajpcell.00228.2010
2010
Eckersley-Maslin MA; Warner FJ; Grzelak CA; McCaughan GW; Shackel NA, 2009, 'Bone marrow stem cells and the liver: Are they relevant?: REVIEW', Journal of Gastroenterology and Hepatology (Australia), vol. 24, pp. 1608 - 1616, http://dx.doi.org/10.1111/j.1440-1746.2009.06004.x
2009
Shackel NA; Patel K; McHutchison J, 2009, 'Cirrhosis in the era of genomic medicine', in Genomic and Personalized Medicine, Two-Vol Set, pp. 1138 - 1154, http://dx.doi.org/10.1016/B978-0-12-369420-1.00093-7
2009
Shackel NA; Jamias J; Rahman W; Prakoso E; Strasser SI; Koorey DJ; Crawford MD; Verran DJ; Gallagher J; McCaughan GW, 2009, 'Early high peak hepatitis C viral load levels independently predict hepatitis C-related liver failure post-liver transplantation', Liver Transplantation, vol. 15, pp. 709 - 718, http://dx.doi.org/10.1002/lt.21747
2009
Shackel NA; Patel K; McHutchison J, 2009, 'Diagnosis, Management and Disease Mechanisms of Hepatitis in the Era of Genomic Medicine', in Genomic and Personalized Medicine, Two-Vol Set, pp. 1375 - 1389, http://dx.doi.org/10.1016/B978-0-12-369420-1.00112-8
2009
Pavendranathan G; Selby W; Shackel NA; Strasser SI; McCaughan GW; Koorey DJ, 2009, 'Colonoscopic Surveillance in Inflammatory Bowel Disease Post Liver Transplant for Primary Sclerosing Cholangitis', in GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, Chicago, IL, pp. A814 - A814, presented at Digestive Disease Week/110th Annual Meeting of the American-Gastroenterological-Association, Chicago, IL, 30 May 2009 - 04 June 2009, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000275277204086&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2009
Sandroussi C; Crawford M; Lockwood DS; Tang P; Gallagher JP; Pleass H; Strasser SI; Shackel NA; McCaughan GW; Verran DJ, 2009, 'Donor and recipient selection leads to good patient and graft outcomes for right lobe split transplantation versus whole graft liver transplantation in adult recipients', Liver Transplantation, vol. 15, pp. 1586 - 1593, http://dx.doi.org/10.1002/lt.21849
2009
Gaudieri S; Rauch A; Pfafferott K; Barnes E; Cheng W; McCaughan G; Shackel N; Jeffrey GP; Mollison L; Baker R; Furrer H; Günthard HF; Freitas E; Humphreys I; Klenerman P; Mallal S; James I; Roberts S; Nolan D; Lucas M, 2009, 'Hepatitis C virus drug resistance and immune-driven adaptations: Relevance to new antiviral therapy', Hepatology, vol. 49, pp. 1069 - 1082, http://dx.doi.org/10.1002/hep.22773
2009
McCaughan GW; Shackel NA; Bertolino P; Bowen DG, 2009, 'Molecular and cellular aspects of hepatitis C virus reinfection after liver transplantation: How the early phase impacts on outcomes', Transplantation, vol. 87, pp. 1105 - 1111, http://dx.doi.org/10.1097/TP.0b013e31819dfa83
2009
Rauch A; James I; Pfafferott K; Nolan D; Klenerman P; Cheng W; Mollison L; McCaughan G; Shackel N; Jeffrey GP; Baker R; Freitas E; Humphreys I; Furrer H; Günthard HF; Hirschel B; Mallal S; John M; Lucas M; Barnes E; Gaudieri S, 2009, 'Divergent adaptation of hepatitis C virus genotypes 1 and 3 to human leukocyte antigen-restricted immune pressure', Hepatology, vol. 50, pp. 1017 - 1029, http://dx.doi.org/10.1002/hep.23101
2009
Shackel NA, 2009, 'Liver "tick tock"', Hepatology, vol. 50, pp. 1310 - 1311, http://dx.doi.org/10.1002/hep.23266
2009
McCaughan GW; Shackel NA; Williams R; Seth D; Haber PS; Gorrell MD, 2008, 'Genomics, Gene Arrays and Proteomics in the Study of Liver Disease', Textbook of Hepatology: From Basic Science to Clinical Practice, Third Edition, pp. 398 - 420, http://dx.doi.org/10.1002/9780470691861.ch3f
2008
Shackel NA; McCaughan GW; Warner FJ, 2008, 'Hepatocellular carcinoma development requires hepatic stem cells with altered transforming growth factor and interleukin-6 signaling', Hepatology, vol. 47, pp. 2134 - 2136, http://dx.doi.org/10.1002/hep.22369
2008
Shackel N; McCaughan G, 2007, 'Treatment for cirrhosis-associated hyponatremia? Vaptans and aquaresis: Commentary', Hepatology, vol. 45, pp. 1080 - 1081, http://dx.doi.org/10.1002/hep.21646
2007
Shackel N; McCaughan G, 2007, 'Treatment for cirrhosis-associated hyponatremia? Vaptans and aquaresis.', in Hepatology, JOHN WILEY & SONS INC, United States, pp. 1080 - 1081, presented at 58th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, United States, 02 November 2007 - 06 November 2007, http://dx.doi.org/10.1002/hep.21646
2007
Richardson SR; Warner FJ; McCaughan GW; Gorrell MD; Lam R; Shackel NA, 2007, 'CD147 regulation of hepatocyte derived matrix metalloproteinases: A novel pathway involved in liver fibrogenesis', in HEPATOLOGY, JOHN WILEY & SONS INC, Boston, MA, pp. 711A - 712A, presented at 58th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, Boston, MA, 02 November 2007 - 06 November 2007, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000249910401329&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2007
Shackel N, 2007, 'Zebrafish and the understanding of liver development: The emerging role of the Wnt pathway in liver biology', Hepatology, vol. 45, pp. 540 - 541, http://dx.doi.org/10.1002/hep.21543
2007
Huang XX; Mccaughan GW; Shackel NA; Gorrell MD, 2007, 'Up-regulation of proproliferative genes and the ligand/receptor pair placental growth factor and vascular endothelial growth factor receptor 1 in hepatitis C cirrhosis', Liver International, vol. 27, pp. 960 - 968, http://dx.doi.org/10.1111/j.1478-3231.2007.01542.x
2007
Shackel NA; McCaughan GW, 2007, 'Intrahepatic interferon-stimulated gene responses: Can they predict treatment responses in chronic hepatitis C infection?', Hepatology, vol. 46, pp. 1326 - 1328, http://dx.doi.org/10.1002/hep.22006
2007
Shackel NA; Warner FJ, 2007, 'Identification of resident hepatic stem cell populations', Hepatology, vol. 46, pp. 2042 - 2044, http://dx.doi.org/10.1002/hep.22091
2007
Shackel NA, 2007, 'Growth factors as indicators of prognosis in liver failure', Journal of Gastroenterology and Hepatology (Australia), vol. 22, pp. 1171 - 1173, http://dx.doi.org/10.1111/j.1440-1746.2007.05005.x
2007
Prakoso E; Jamias JD; James MW; Koorey DJ; Strasser SI; McCaughan GW; Shackel NA, 2007, 'Terlipressin therapy for renal dysfunction and hyponatremia in patients with liver failure', in HEPATOLOGY, JOHN WILEY & SONS INC, Boston, MA, pp. 599A - 599A, presented at 58th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, Boston, MA, 02 November 2007 - 06 November 2007, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000249910401078&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2007
Shackel NA; McCaughan GW, 2006, 'Liver biopsy: Is it still relevant?', Internal Medicine Journal, vol. 36, pp. 689 - 691, http://dx.doi.org/10.1111/j.1445-5994.2006.01210.x
2006
Shackel NA; Jamias J; Rahman W; Strasser SI; Koorey DJ; McGuiness P; Guney S; McCaughan GW, 2006, 'A study of hepatitis C viral load and calcineurin immunosuppression post liver transplantation', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol. 21, pp. A301 - A301, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000247320600107&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2006
Rahman W; Huang P; Belov L; Sharland A; Jamias J; Chrisp J; McCaughan GW; Shackel NA, 2006, 'Immunophenotyping of human liver disease using a cluster of differentiation (CD) antibody microarray', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol. 21, pp. A312 - A312, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000247320600129&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2006
Shackel NA; Seth D; Haber PS; Gorrell MD; McCaughan GW, 2006, 'The hepatic transcriptome in human liver disease', Comparative Hepatology, vol. 5, http://dx.doi.org/10.1186/1476-5926-5-6
2006
Rahman W; Huang P; Bevlov L; Sharland A; Jamias JD; Chrisp J; McCaughan GW; Shackel NA, 2006, 'Immunophenotyping of human liver disease using a cluster of differentiation (CD) antibody microarray', in HEPATOLOGY, JOHN WILEY & SONS INC, Boston, MA, pp. 621A - 622A, presented at 57th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, Boston, MA, 27 October 2006 - 31 October 2006, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000241362302254&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2006
Richardson S; McCaughan GW; Warner FJ; Gorrell MD; Shackel NA, 2006, 'CD147 is a novel mediator of hepatocyte extracellular matrix interactions', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol. 21, pp. A303 - A303, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000247320600112&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2006
Shackel N; Rockey D, 2005, 'In pursuit of the "holy grail" - Stem cells, hepatic injury, fibrogenesis and repair', Hepatology, vol. 41, pp. 16 - 18, http://dx.doi.org/10.1002/hep.20551
2005
Shackel NA; Rockey DC, 2004, 'Stem cells and liver disease: promise laced with confusion and intrigue.', Gastroenterology, vol. 127, pp. 346 - 348, http://dx.doi.org/10.1053/j.gastro.2004.02.078
2004
Shackel NA; Rockey DC, 2004, 'Intrahepatic gene silencing by RNA interference.', Gastroenterology, vol. 126, pp. 356 - 358, http://dx.doi.org/10.1053/j.gastro.2003.07.023
2004
Shackel NA; McGuinness PH; Abbott CA; Gorrell MD; McCaughan GW, 2003, 'Novel differential gene expression in human cirrhosis detected by suppression subtractive hybridization', Hepatology, vol. 38, pp. 577 - 588, http://dx.doi.org/10.1053/jhep.2003.50376
2003
Huang XX; Gorrell MD; Williams RBH; Seth D; Shackel NA; McCaughan GW, 2003, 'The hepatic transcriptome in hepatitis C virus (HCV) associated cirrhosis with hepatocellular cancer (HCC): Is there a premalignant profile?', in HEPATOLOGY, W B SAUNDERS CO, BOSTON, MASSACHUSETTS, pp. 355A - 355A, presented at 54th Annual Meeting of the American-Association-for-the-Study-of-Liver-Disease, BOSTON, MASSACHUSETTS, 24 October 2003 - 28 October 2003, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000185816700405&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2003
Shackel NA; McGuinness PH; Abbott CA; Gorrell MD; McCaughan GW, 2002, 'Insights into the pathobiology of hepatitis C virus-associated cirrhosis: Analysis of intrahepatic differential gene expression', American Journal of Pathology, vol. 160, pp. 641 - 654, http://dx.doi.org/10.1016/S0002-9440(10)64884-5
2002
Shackel NA; Gorrell MD; McCaughan GW, 2002, 'Gene array analysis and the liver', Hepatology, vol. 36, pp. 1313 - 1325, http://dx.doi.org/10.1053/jhep.2002.36950
2002
Shackel NA; McGuinness PH; Wang XM; Ajami K; McCaughan GW; Gorrell MD; Morrow AW, 2002, 'Characterisation of intrahepatic discoidin domain receptor 1 (DDR-1/CD167A) in human cirrhosis: Down-stream characterisation of novel differential expression identified by gene array analysis.', in HEPATOLOGY, W B SAUNDERS CO, BOSTON, MASSACHUSETTS, pp. 482A - 482A, presented at 53rd Annual Meeting of the Association-for-the-Study-of-Liver-Diseases (AASLD), BOSTON, MASSACHUSETTS, 01 November 2002 - 05 November 2002, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000178301701260&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2002
Huang XX; Seth D; Shackel NA; McCaughan GW; Gorrell MD; Morrow AW, 2002, 'An extended analysis of the liver transcriptome in hepatitis C virus associated cirrhosis.', in HEPATOLOGY, W B SAUNDERS CO, BOSTON, MASSACHUSETTS, pp. 439A - 439A, presented at 53rd Annual Meeting of the Association-for-the-Study-of-Liver-Diseases (AASLD), BOSTON, MASSACHUSETTS, 01 November 2002 - 05 November 2002, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000178301701086&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2002
McCaughan GW; Shackel NA; Gorrell MD, 2001, 'Discussion on differential gene expression between chronic hepatitis B and C hepatic lesion', Gastroenterology, vol. 120, pp. 955 - 966, http://dx.doi.org/10.1053/gast.2001.29470
2001
Shackel NA; McGuinness P; Abbott C; Gorrell M; McCaughan G, 2001, 'Transcriptional profiling of primary sclerosing cholangitis identifies novel epithelial associated gene expression.', HEPATOLOGY, vol. 34, pp. 364A - 364A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000171224700764&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2001
Yin JL; Shackel NA; Zekry A; McGuinness PH; Richards C; Van Der Putten K; McCaughan GW; Eris JM; Bishop GA, 2001, 'Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) for measurement of cytokine and growth factor mRNA expression with fluorogenic probes or SYBR Green I', Immunology and Cell Biology, vol. 79, pp. 213 - 221, http://dx.doi.org/10.1046/j.1440-1711.2001.01002.x
2001
Shackel NA; McGuinness PM; Abbott CA; Gorrell MD; McCaughan GW, 2001, 'Transcriptional profiling of gene expression implicates novel genes in the cellular apoptosis of hepatitis C cirrhosis', GASTROENTEROLOGY, vol. 120, pp. A7 - A7, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000168514700033&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2001
Shackel NA; McGuinness PH; Abbott CA; Gorrell MD; McCaughan GW, 2001, 'Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis: cDNA array analysis of intrahepatic differential gene expression', Gut, vol. 49, pp. 565 - 576, http://dx.doi.org/10.1136/gut.49.4.565
2001
Shackel NA; McGuinness PH; Abbott CA; Gorrell MD; McCaughan GW, 2000, 'Fibrosis associated molecular pathways in endstage cirrhosis examined by cDNA array analysis.', HEPATOLOGY, vol. 32, pp. 191A - 191A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000089622400115&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2000
Shackel NA; McGuinness PH; Abbott CA; Gorrell MD; McCaughan GW, 2000, 'The WNT pathway is implicated in the pathogenesis of PBC associated cirrhosis following examination of differential gene expression by cDNA array analysis.', HEPATOLOGY, vol. 32, pp. 300A - 300A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000089622400550&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2000
McCaughan GW; Gorrell MD; Bishop GA; Abbott CA; Shackel NA; McGuinness PH; Levy MT; Sharland AF; Bowen DG; Yu D; Slaitini L; Church WB; Napoli J, 2000, 'Molecular pathogenesis of liver disease: An approach to hepatic inflammation, cirrhosis and liver transplant tolerance', Immunological Reviews, vol. 174, pp. 172 - 191, http://dx.doi.org/10.1034/j.1600-0528.2002.017420.x
2000
Bowen DG; Shackel NA; McCaughan GW, 2000, 'East meets West: Acute liver failure in the global village', Journal of Gastroenterology and Hepatology (Australia), vol. 15, pp. 467 - 469, http://dx.doi.org/10.1046/j.1440-1746.2000.02182.x
2000
Shackel NA; McGuinness P; Morrow AW; Abbott C; Gorrell M; McCaughan G, 1999, 'Intrahepatic differential gene expression analysis used to examine pathogenic pathways in hepatitis C cirrhosis.', HEPATOLOGY, vol. 30, pp. 423A - 423A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000082794701049&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
1999
Shackel NA; Bowen DG; Selby WS, 1998, 'Video push enteroscopy in the investigation of small bowel disease: Defining clinical indications and outcomes', Australian and New Zealand Journal of Medicine, vol. 28, pp. 198 - 203, http://dx.doi.org/10.1111/j.1445-5994.1998.tb02969.x
1998
Shackel NA; Day RO; Kellett B; Brooks PM, 1997, 'Copper-salicylate gel for pain relief in osteoarthritis - a randomised controlled trial.', Medical Journal of Australia, vol. 167, pp. 134 - 136
1997
Shackel NA; Speisky H; Wade DN, 1992, 'Hepatic glutathione degradation within the sinusoids of guinea pig livers shows a periportal localization of gamma-glutamyl transferase activity', Agents and Actions, vol. 36, pp. 289 - 293
1992
Speisky H; Shackel N; Varghese G; Wade D; Israel Y, 1990, 'Role of hepatic γ‐glutamyltransferase in the degradation of circulating glutathione: Studies in the intact guinea pig perfused liver', Hepatology, vol. 11, pp. 843 - 849, http://dx.doi.org/10.1002/hep.1840110520
1990