Maté Biro

EMBL Australia Group Leader
Senior Lecturer

Visit the Biro Group website at EMBL Australia

Biro Group Embl Australia

 

 

 

 

 

Dr Maté Biro received his PhD with summa cum laude at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany. 

Dr. Biro has previously worked at the Centenary Institute of Cancer Medicine and Cell Biology in Sydney, in the Imaging Informatics division at the Bioinformatics Institute of A*STAR in Singapore, at the MIT BioImaging Center in Cambridge, MA, USA and in the Belle collaboration at the KEK: High Energy Accelerator Research Organisation in Tsukuba, Japan.

As an EMBL Australia Group Leader he will expand his exciting studies on the way actomyosin complexes control cell shape, homeostasis and migration in cancer and immune function, focusing on the elucidation of biomechanical interaction within and between cells.

Dr. Biro is spearheading the use of complex in vitro and in vivo models for studying the cell-intrinsic actin cytoskeleton cues and dynamics that govern the invasive migration of tumour cells, the tissue scanning of T cells and their cytotoxic interaction with tumour cells. Using a multidisciplinary approach encompassing cell biology, biophysics, bioimage informatics and advanced light microscopy, he aims to unravel fundamental actin-based processes and develop new methodologies for basic cell biological research. Dr. Biro's research relies heavily on advanced microscopy and the development of image analysis platforms capable of automatically detecting and analysing the kinetics of actomyosin, cell movement and protrusions.

Dr. Biro's group is primarily concerned with the cell biology and mechanics of the actin cytoskeleton, and how immune cells (T cells) locate and kill cancer cells.

Main research topics are:

  • Mechanobiology of immune cell-tumour cell interactions
  • Single cell and population-wide immune cell migration dynamics
  • Advanced imaging and image analysis
  • Computational modelling and simulations

The group uses high-speed imaging to watch how cells move throughout complex 3-dimensional environments and also uses single molecule microscopes to observe the dynamics of actomyosin, a major and the force-generating component of the cytoskeleton.

When he is not involved with research Dr. Biro enjoys flying all things powered or unpowered and discovering the marvels of the underwater world whilst diving. He is also always happy to discuss his research and other passions over a beer...

publications

Journal articles
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Galeano Niño JL; Tay SS; Tearle JLE; Xie J; Govendir MA; Kempe D; Mazalo J; Drew AP; Colakoglu F; Kummerfeld SK; Proud CG; Biro M, 2020, 'The Lifeact-EGFP mouse is a translationally controlled fluorescent reporter of T cell activation.', J Cell Sci, vol. 133, http://dx.doi.org/10.1242/jcs.238014
2020
Obeidy P; Ju LA; Oehlers SH; Zulkhernain NS; Lee Q; Galeano Niño JL; Kwan RYQ; Tikoo S; Cavanagh LL; Mrass P; Cook AJL; Jackson SP; Biro M; Roediger B; Sixt M; Weninger W, 2020, 'Partial loss of actin nucleator actin-related protein 2/3 activity triggers blebbing in primary T lymphocytes', Immunology and Cell Biology, vol. 98, pp. 93 - 113, http://dx.doi.org/10.1111/imcb.12304
2020
Redpath GMI; Ecker M; Kapoor-Kaushik N; Vartoukian H; Carnell M; Kempe D; Biro M; Ariotti N; Rossy J, 2019, 'Flotillins promote T cell receptor sorting through a fast Rab5–Rab11 endocytic recycling axis', Nature Communications, vol. 10, http://dx.doi.org/10.1038/s41467-019-12352-w
2019
Mitchell CB; Black B; Sun F; Chrzanowski W; Cooper-White J; Maisonneuve B; Stringer B; Day B; Biro M; O’Neill GM, 2019, 'Tropomyosin Tpm 2.1 loss induces glioblastoma spreading in soft brain-like environments', Journal of Neuro-Oncology, vol. 141, pp. 303 - 313, http://dx.doi.org/10.1007/s11060-018-03049-z
2019
Meiring JCM; Bryce NS; Niño JLG; Gabriel A; Tay SS; Hardeman EC; Biro M; Gunning PW, 2019, 'Tropomyosin concentration but not formin nucleators mDia1 and mDia3 determines the level of tropomyosin incorporation into actin filaments', Scientific Reports, vol. 9, http://dx.doi.org/10.1038/s41598-019-42977-2
2019
Lamm N; Masamsetti P; Read M; Biro M; Cesare A, 2018, 'ATR and mTOR regulate F-actin to alter nuclear architecture and repair replication stress', Nuclear filamentous actin functions in the replication stress response, http://dx.doi.org/10.1101/451708
2018
Zenker J; White MD; Gasnier M; Alvarez YD; Lim HYG; Bissiere S; Biro M; Plachta N, 2018, 'Expanding Actin Rings Zipper the Mouse Embryo for Blastocyst Formation', Cell, vol. 173, pp. 776 - 791.e17, http://dx.doi.org/10.1016/j.cell.2018.02.035
2018
Moran I; Nguyen A; Khoo WH; Butt D; Bourne K; Young C; Hermes JR; Biro M; Gracie G; Ma CS; Munier CML; Luciani F; Zaunders J; Parker A; Kelleher AD; Tangye SG; Croucher PI; Brink R; Read MN; Phan TG, 2018, 'Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-05772-7
2018
Pageon SV; Govendir MA; Kempe D; Biro M, 2018, 'Mechanoimmunology: Molecular-scale forces govern immune cell functions', Molecular Biology of the Cell, vol. 29, pp. 1919 - 1926, http://dx.doi.org/10.1091/mbc.E18-02-0120
2018
Marshal AD; Bailey CG; Champ K; Vellozzi M; O'Young P; Metierre C; Feng Y; Thoeng A; Richards AM; Schmitz U; Biro M; Jayasinghe R; Ding L; Anderson L; Mardis ER; Rasko JEJ, 2017, 'CTCF genetic alterations in endometrial carcinoma are pro-tumorigenic', Oncogene, vol. 36, pp. 4100 - 4110, http://dx.doi.org/10.1038/onc.2017.25
2017
Sedzinski J; Hannezo E; Tu F; Biro M; Wallingford JB, 2017, 'RhoA regulates actin network dynamics during apical surface emergence in multiciliated epithelial cells', Journal of Cell Science, vol. 130, pp. 420 - 428, http://dx.doi.org/10.1242/jcs.194704
2017
Newman P; Galeano Niño JL; Graney P; Razal JM; Minett AI; Ribas J; Ovalle-Robles R; Biro M; Zreiqat H, 2017, 'Corrigendum: Relationship between nanotopographical alignment and stem cell fate with live imaging and shape analysis', Scientific reports, vol. 7, pp. 43073, http://dx.doi.org/10.1038/srep43073
2017
Sedzinski J; Hannezo E; Tu F; Biro M; Wallingford JB, 2017, 'Correction: RhoA regulates actin network dynamics during apical surface emergence in multiciliated epithelial cells [J. Cell Sci. 130, (420-428)]', Journal of Cell Science, vol. 130, pp. 1017, http://dx.doi.org/10.1242/jcs.202234
2017
Galeano Niño JL; Kwan RYQ; Weninger W; Biro M, 2016, 'Antigen-specific T cells fully conserve antitumour function following cryopreservation', Immunology and Cell Biology, vol. 94, pp. 411 - 418, http://dx.doi.org/10.1038/icb.2015.105
2016
Newman P; Galenano-Ninõ JL; Graney P; Razal JM; Minett AI; Ribas J; Ovalle-Robles R; Biro M; Zreiqat H, 2016, 'Relationship between nanotopographical alignment and stem cell fate with live imaging and shape analysis', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep37909
2016
Sedzinski J; Hannezo E; Tu F; Biro M; Wallingford JB, 2016, 'Emergence of an Apical Epithelial Cell Surface In Vivo', Developmental Cell, vol. 36, pp. 24 - 35, http://dx.doi.org/10.1016/j.devcel.2015.12.013
2016
Tay SS; Carol H; Biro M, 2016, 'TriKEs and BiKEs join CARs on the cancer immunotherapy highway', Human Vaccines and Immunotherapeutics, vol. 12, pp. 2790 - 2796, http://dx.doi.org/10.1080/21645515.2016.1198455
2016
Tong PL; Roediger B; Kolesnikoff N; Biro M; Tay SS; Jain R; Shaw LE; Grimbaldeston MA; Weninger W, 2015, 'The skin immune atlas: Three-dimensional analysis of cutaneous leukocyte subsets by multiphoton microscopy', Journal of Investigative Dermatology, vol. 135, pp. 84 - 93, http://dx.doi.org/10.1038/jid.2014.289
2015
Newman P; Lu Z; Roohani-Esfahani SI; Church TL; Biro M; Davies B; King A; Mackenzie K; Minett AI; Zreiqat H, 2015, 'Porous and strong three-dimensional carbon nanotube coated ceramic scaffolds for tissue engineering', Journal of Materials Chemistry B, vol. 3, pp. 8337 - 8347, http://dx.doi.org/10.1039/c5tb01052g
2015
Weninger W; Biro M; Jain R, 2014, 'Leukocyte migration in the interstitial space of non-lymphoid organs', Nature Reviews Immunology, vol. 14, pp. 232 - 246, http://dx.doi.org/10.1038/nri3641
2014
Bovellan M; Romeo Y; Biro M; Boden A; Chugh P; Yonis A; Vaghela M; Fritzsche M; Moulding D; Thorogate R; Jégou A; Thrasher AJ; Romet-Lemonne G; Roux PP; Paluch EK; Charras G, 2014, 'Cellular control of cortical actin nucleation', Current Biology, vol. 24, pp. 1628 - 1635, http://dx.doi.org/10.1016/j.cub.2014.05.069
2014
Munoz MA; Biro M; Weninger W, 2014, 'T cell migration in intact lymph nodes in vivo', Current Opinion in Cell Biology, vol. 30, pp. 17 - 24, http://dx.doi.org/10.1016/j.ceb.2014.05.002
2014
Biro M; Munoz MA; Weninger W, 2014, 'Targeting Rho-GTPases in immune cell migration and inflammation', British Journal of Pharmacology, vol. 171, pp. 5491 - 5506, http://dx.doi.org/10.1111/bph.12658
2014
Biro M; Romeo Y; Kroschwald S; Bovellan M; Boden A; Tcherkezian J; Roux PP; Charras G; Paluch EK, 2013, 'Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging', Cytoskeleton, vol. 70, pp. 741 - 754, http://dx.doi.org/10.1002/cm.21142
2013
Puah WC; Cheok LP; Biro M; Ng WT; Wasser M, 2011, 'TLM-converter: Reorganization of long time-lapse microscopy datasets for downstream image analysis', BioTechniques, vol. 51, pp. 49 - 54, http://dx.doi.org/10.2144/000113704
2011
Sedzinski J; Biro M; Oswald A; Tinevez JY; Salbreux G; Paluch E, 2011, 'Polar actomyosin contractility destabilizes the position of the cytokinetic furrow', Nature, vol. 476, pp. 462 - 468, http://dx.doi.org/10.1038/nature10286
2011
Biro M; Kroschwald S; Paluch E, 2010, 'Analysis of De Novo Cell Cortex Assembly in Blebs as a Novel Assay for Probing Cortical Dynamics and Regulation', BIOPHYSICAL JOURNAL, vol. 98, pp. 159A - 159A, http://dx.doi.org/10.1016/j.bpj.2009.12.853
2010
Conference Papers
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McDonald M; Khoo WH; Mohanty S; Terry R; Chai R; Quinn J; Pettitt J; Xiao Y; Baldock P; Rogers M; Croucher P; Phan T; Ng PY; Pavlos N; Biro M, 2019, 'Intravital imaging of osteoclasts in vivo reveals novel osteoclast fate which may underlie the therapeutic response to Denosumab withdrawal', in JOURNAL OF BONE AND MINERAL RESEARCH, WILEY, Orlando, FL, pp. 44 - 45, presented at Annual Meeting of the American-Society-for-Bone-and Mineral Research, Orlando, FL, 20 September 2019 - 23 September 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000508356600130&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2019
Tong PL; Roediger B; Kolesnikoff N; Tay SS; Biro M; Shaw L; Jain R; Grimbaldeston M; Weninger W, 2014, 'The immune atlas of the skin: A topographical three-dimensional study using multiphoton microscopy and multi-parameter flow cytometry', in AUSTRALASIAN JOURNAL OF DERMATOLOGY, WILEY-BLACKWELL, pp. 20 - 21, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335981400070&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2014
Sedzinski J; Biro M; Oswald A; Tinevez J-Y; Salbreux G; Paluch E, 2011, 'Mechanism of the actin cortex and shape stability during cytokinesis', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Denver, CO, presented at Annual Meeting of the American-Society-for-Cell-Biology (ASCB), Denver, CO, 03 December 2011 - 07 December 2011, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000305505502499&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2011
Sedzinski J; Biro M; Salbreux G; Paluch E, 2011, 'Polar acto-myosin contractility and cleavage furrow stability during cytokinesis', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Denver, CO, presented at Annual Meeting of the American-Society-for-Cell-Biology (ASCB), Denver, CO, 03 December 2011 - 07 December 2011, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000305505500093&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2011
Sedzinski J; Biro M; Oswald A; Tinevez J-Y; Salbreux G; Paluch E, 2011, 'Polar actin cortex mechanics and cell shape stability during cytokinesis', in EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, SPRINGER, Budapest, HUNGARY, pp. 213 - 213, presented at 8th EBSA European Biophysics Congress, Budapest, HUNGARY, 23 August 2011 - 27 August 2011, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000293637300601&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2011
Conference Abstracts
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McDonald M; Khoo WH; Mohanty S; Terry R; Chai R; Quinn J; Pettitt J; Xiao Y; Baldock P; Rogers M; Croucher P; Tri P; Ng PY; Pavlos N; Biro M, 2019, 'Intravital imaging of osteoclasts in vivo reveals novel osteoclast fate which may underlie the therapeutic response to Denosumab withdrawal', in JOURNAL OF BONE AND MINERAL RESEARCH, WILEY, Orlando, FL, Vol. 34, pp. 44 - 45, presented at Annual Meeting of the American-Society-for-Bone-and Mineral Research, Orlando, FL, 20 September 2019 - 23 September 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000508614700130&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2019
Book Chapters
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Biro M; Maître JL, 2015, 'Dual pipette aspiration: Aunique tool for studying intercellular adhesion', in Methods in Cell Biology, pp. 255 - 267, http://dx.doi.org/10.1016/bs.mcb.2014.10.007
2015
Datasets
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Weninger W; Biro M, 2015, Faculty of 1000 evaluation for Actin depletion initiates events leading to granule secretion at the immunological synapse., http://dx.doi.org/10.3410/f.725506810.793507006
2015
Weninger W; Biro M; Jain R, 2014, Faculty of 1000 evaluation for Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix., http://dx.doi.org/10.3410/f.718547671.793499677
2014