Associate Professor Luke Hesson

Adjunct Associate Professor

Fellow of the Faculty of Science of the Royal College of Pathologists of Australasia (FFSc RCPA (Research)), 2017

PhD (Clinical Genetics), University of Birmingham, 2005

BMedSc (Hons), University of Birmingham, 2001

Medicine & Health

School of Clinical Medicine

Associate Professor Luke Hesson is a Clinical Genetics Scientist and cancer researcher. He holds a doctorate in Clinical Genetics from The University of Birmingham UK and is a Fellow of the Faculty of Science of the Royal College of Pathologists of Australasia (RCPA). He is affiliated with Douglass Hanly Moir Pathology where he provides scientific supervision of the Molecular Genetics Department, UNSW Sydney where he lectures in genetics, epigenetics, cancer, pathology and personalised medicine, and is a Visiting Scientist at the Garvan Institute of Medical Research. He is a Technical Assessor for the National Association of Testing Authorities (NATA), a member of the RCPA Quality Assurance Program Advisory Committee, and former Director of the Australian Society for Medical Research.

He has 20 years’ experience investigating the genetic and epigenetic causes of cancer with >80 peer-reviewed publications (>4500 citations, h-index 34) and has contributed to knowledge of the genes and types of molecular alterations that contribute to a range of diseases. This includes the development of clinically accredited genetic tests for use by pathology laboratories.

E-mail

l.hesson@unsw.edu.au

Book Chapters | 2019

Hesson LB; Pritchard AL, 2019, 'Genetics and Epigenetics: A Historical Overview', in Clinical Epigenetics, Springer Singapore, pp. 1 - 46, http://dx.doi.org/10.1007/978-981-13-8958-0_1

Book Chapters | 2019

Hesson LB; Sloane MA; Pritchard AL, 2019, 'The Clinical Utility of Epigenetics: A Case Study', in Clinical Epigenetics, Springer Singapore, pp. 247 - 265, http://dx.doi.org/10.1007/978-981-13-8958-0_11

Book Chapters | 2016

Kuroiwa-Trzmielina J; Hesson LB, 2016, 'Epigenetic Effects of Gut Microbiota on Obesity and Gastrointestinal Cancers', in Berger NA (ed.), EPIGENETICS, ENERGY BALANCE, AND CANCER, edn. Energy Balance and Cancer, SPRINGER INTERNATIONAL PUBLISHING AG, pp. 167 - 189, http://dx.doi.org/10.1007/978-3-319-41610-6_7
Journal articles | 2023

Saya S; Chondros P; Abela A; Mihalopolous C; Chatterton ML; Gunn J; Chen TF; Polasek TM; Dettmann E; Brooks R; King M; Spencer L; Alphonse P; Milton S; Ramsay G; Siviour Z; Liew J; Ly P; Thoenig M; Seychell R; La Rocca F; Hesson LB; Mejias N; Sivertsen T; Galea MA; Bousman C; Emery J, 2023, 'The PRESIDE (PhaRmacogEnomicS In DEpression) Trial: a double-blind randomised controlled trial of pharmacogenomic-informed prescribing of antidepressants on depression outcomes in patients with major depressive disorder in primary care', Trials, 24, pp. 342, http://dx.doi.org/10.1186/s13063-023-07361-6

Journal articles | 2022

Bournazos AM; Riley LG; Bommireddipalli S; Ades L; Akesson LS; Al-Shinnag M; Alexander SI; Archibald AD; Balasubramaniam S; Berman Y; Beshay V; Boggs K; Bojadzieva J; Brown NJ; Bryen SJ; Buckley MF; Chong B; Davis MR; Dawes R; Delatycki M; Donaldson L; Downie L; Edwards C; Edwards M; Engel A; Ewans LJ; Faiz F; Fennell A; Field M; Freckmann ML; Gallacher L; Gear R; Goel H; Goh S; Goodwin L; Hanna B; Harraway J; Higgins M; Ho G; Hopper BK; Horton AE; Hunter MF; Huq AJ; Josephi-Taylor S; Joshi H; Kirk E; Krzesinski E; Kumar KR; Lemckert F; Leventer RJ; Lindsey-Temple SE; Lunke S; Ma A; Macaskill S; Mallawaarachchi A; Marty M; Marum JE; McCarthy HJ; Menezes MP; McLean A; Milnes D; Mohammad S; Mowat D; Niaz A; Palmer EE; Patel C; Patel SG; Phelan D; Pinner JR; Rajagopalan S; Regan M; Rodgers J; Rodrigues M; Roxburgh RH; Sachdev R; Roscioli T; Samarasekera R; Sandaradura SA; Savva E; Schindler T; Shah M; Sinnerbrink IB; Smith JM; Smith RJ; Springer A; Stark Z; Strom SP; Sue CM; Tan K; Tan TY; Tantsis E; Tchan MC; Thompson BA; Trainer AH; van Spaendonck-Zwarts K; Walsh R; Warwick L; White S; White SM; Williams MG, 2022, 'Standardized practices for RNA diagnostics using clinically accessible specimens reclassifies 75% of putative splicing variants', Genetics in Medicine, 24, pp. 130 - 145, http://dx.doi.org/10.1016/j.gim.2021.09.001

Journal articles | 2022

Lin V; Chung IY; Toumi E; McKay D; McKenzie J; McKelvie P; Zabih F; Hoffmeister A; Wright D; Ntzaferi A; Wu IJ; Hesson L; Fung A; Lim LA; Wong S; Field A; Earls P; Giblin M; Conway RM; Cherepanoff S, 2022, 'Biopsy for molecular risk stratification in uveal melanoma: Yields and molecular characteristics in 119 patients', Clinical and Experimental Ophthalmology, 50, pp. 50 - 61, http://dx.doi.org/10.1111/ceo.14022

Journal articles | 2021

Gifford G; Hesson L; Wong JWH; Carroll A; Gabrielli S; Bai LJ; Xia W; Stevenson W; Greenwood M, 2021, 'Poor mobilization of autologous CD34⁺ peripheral blood stem cells in haematology patients undergoing autologous stem cell transplantation is associated with the presence of variants in genes implicated in clonal haematopoiesis of indeterminant potential', British Journal of Haematology, 193, pp. 841 - 844, http://dx.doi.org/10.1111/bjh.17316

Journal articles | 2021

Palmer EE; Sachdev R; Macintosh R; Melo US; Mundlos S; Righetti S; Kandula T; Minoche AE; Puttick C; Gayevskiy V; Hesson L; Idrisoglu S; Shoubridge C; Thai MHN; Davis RL; Drew AP; Sampaio H; Andrews PI; Lawson J; Cardamone M; Mowat D; Colley A; Kummerfeld S; Dinger ME; Cowley MJ; Roscioli T; Bye A; Kirk E, 2021, 'Diagnostic Yield of Whole Genome Sequencing After Nondiagnostic Exome Sequencing or Gene Panel in Developmental and Epileptic Encephalopathies', Neurology, 96, pp. E1770 - E1782, http://dx.doi.org/10.1212/WNL.0000000000011655

Journal articles | 2021

Yeola A; Subramanian S; Oliver RA; Lucas CA; Thoms JAI; Yan F; Olivier J; Chacon D; Tursky ML; Hung T; Power C; Hardy P; D. D; McCarroll J; Kavallaris M; Hesson LB; Beck D; Curtis DJ; Wong JWH; Hardeman EC; Walsh WR; Mobbs R; Chandrakanthan V; Pimanda JE, 2021, 'Induction of Muscle Regenerative Multipotent Stem Cells from Human Adipocytes by PDGF-AB and 5-Azacytidine', Science Advances, pp. 2020.06.04.130872 - 2020.06.04.130872, http://dx.doi.org/10.1126/sciadv.abd1929

Journal articles | 2021

Yeola A; Subramanian S; Oliver RA; Lucas CA; Thoms JAI; Yan F; Olivier J; Chacon D; Tursky ML; Srivastava P; Potas JR; Hung T; Power C; Hardy P; Ma DD; Kilian KA; McCarroll J; Kavallaris M; Hesson LB; Beck D; Curtis DJ; Wong JWH; Hardeman EC; Walsh WR; Mobbs R; Chandrakanthan V; Pimanda JE, 2021, 'Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine', Science Advances, 7, pp. eabd1929 - eabd1929, http://dx.doi.org/10.1126/sciadv.abd1929

Journal articles | 2020

Morris MJ; Hesson LB; Youngson NA, 2020, 'Non-CpG methylation biases bisulphite PCR towards low or unmethylated mitochondrial DNA: recommendations for the field', ENVIRONMENTAL EPIGENETICS, 6, http://dx.doi.org/10.1093/eep/dvaa001

Journal articles | 2020

Van Ly D; Wang D; Conway RM; Giblin M; Liang S; Lukeis R; Lim LA; Hesson L; Cherepanoff S, 2020, 'Lipid-Producing Ciliochoroidal Melanoma with Expression of HMG-CoA Reductase', Ocular Oncology and Pathology, 6, pp. 416 - 421, http://dx.doi.org/10.1159/000510393

Journal articles | 2019

Poulos RC; Perera D; Packham D; Shah A; Janitz C; Pimanda JE; Hawkins N; Ward RL; Hesson LB; Wong JWH, 2019, 'Scarcity of Recurrent Regulatory Driver Mutations in Colorectal Cancer Revealed by Targeted Deep Sequencing', JNCI CANCER SPECTRUM, 3, http://dx.doi.org/10.1093/jncics/pkz012

Journal articles | 2018

Berbic M; Hesson L; Ho LL; Kyle P; Mina K, 2018, 'Case study – Reproductive risk of clinically relevant thalassaemia despite mild microcytosis and normal thalassaemia screen', Pathology, 50, pp. S63 - S63, http://dx.doi.org/10.1016/j.pathol.2017.12.148

Journal articles | 2018

Jacquelin S; Straube J; Cooper L; Vu T; Song A; Bywater M; Baxter E; Heidecker M; Wackrow B; Porter A; Ling V; Green J; Austin R; Kazakoff S; Waddell N; Hesson LB; Pimanda JE; Stegelmann F; Bullinger L; Döhner K; Rampal RK; Heckl D; Hill GR; Lane SW, 2018, 'Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation', Blood, 132, pp. 2707 - 2721, http://dx.doi.org/10.1182/blood-2018-04-846220

Journal articles | 2018

Liu Q; Thoms JAI; Nunez AC; Huang Y; Knezevic K; Packham D; Poulos RC; Williams R; Beck D; Hawkins NJ; Ward RL; Wong JWH; Hesson LB; Sloane MA; Pimanda JE, 2018, 'Disruption of a 35 KB enhancer impairs CTCF binding and MLH1 expression in colorectal cells', Clinical Cancer Research, 24, pp. 4602 - 4611, http://dx.doi.org/10.1158/1078-0432.CCR-17-3678

Journal articles | 2018

Morris MJ; Hesson LB; Poulos RC; Ward RL; Wong JWH; Youngson NA, 2018, 'Reduced nuclear DNA methylation and mitochondrial transcript changes in adenomas do not associate with mtDNA methylation', Biomarker Research, 6, pp. 37, http://dx.doi.org/10.1186/s40364-018-0151-x

Journal articles | 2018

Unnikrishnan A; Vo ANQ; Pickford R; Raftery MJ; Nunez AC; Verma A; Hesson LB; Pimanda JE, 2018, 'AZA-MS: A novel multiparameter mass spectrometry method to determine the intracellular dynamics of azacitidine therapy in vivo', Leukemia, 32, pp. 900 - 910, http://dx.doi.org/10.1038/leu.2017.340

Journal articles | 2017

Jacquelin S; Straube J; Song A; Cooper L; Vu T; Heidecker M; Pimanda J; Hesson L; Hill G; Cloonan N; Heckl D; Lane S, 2017, 'IN VIVO CRISPR EDITING OF DNMT3A IN JAK2V617F HEMATOPOIETIC STEM CELLS INDUCES MYELOFIBROSIS', EXPERIMENTAL HEMATOLOGY, 53, pp. S95 - S95, http://dx.doi.org/10.1016/j.exphem.2017.06.224

Journal articles | 2017

Luo A; Leach ST; Barres R; Hesson LB; Grimm MC; Simar D, 2017, 'The microbiota and epigenetic regulation of t helper 17/regulatory T cells: In search of a balanced immune system', Frontiers in Immunology, 8, pp. 417, http://dx.doi.org/10.3389/fimmu.2017.00417

Journal articles | 2017

Ma SSQ; Henry CE; Llamosas E; Higgins R; Daniels B; Hesson LB; Hawkins NJ; Ward RL; Ford CE, 2017, 'Validation of specificity of antibodies for immunohistochemistry: the case of ROR2', Virchows Archiv : an international journal of pathology, 470, pp. 99 - 108, http://dx.doi.org/10.1007/s00428-016-2019-5

Journal articles | 2016

Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A; Villanueva JE; Nunez AC; Knezevic K; Palu C; Nasrallah R; Carnell M; Macmillan A; Whan R; Yu Y; Hardy P; Grey ST; Gladbach A; Delerue F; Ittner L; Mobbs R; Walkley CR; Purton LE; Ward RL; Wong JWH; Hesson LB; Walsh W; Pimanda JE, 2016, 'Pdgf-ab and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', Proceedings of the National Academy of Sciences of the United States of America, 113, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113

Journal articles | 2016

Hesson LB; Ng B; Zarzour P; Srivastava S; Kwok CT; Packham D; Nunez AC; Beck D; Ryan R; Dower A; Ford CE; Pimanda JE; Sloane MA; Hawkins NJ; Bourke MJ; Wong JWH; Ward RL, 2016, 'Integrated genetic, epigenetic, and transcriptional profiling identifies molecular pathways in the development of laterally spreading tumors', Molecular Cancer Research, 14, pp. 1217 - 1228, http://dx.doi.org/10.1158/1541-7786.MCR-16-0175

Journal articles | 2016

Liu Q; Hesson LB; Nunez AC; Packham D; Hawkins NJ; Ward RL; Sloane MA, 2016, 'Pathogenic germline MCM9 variants are rare in Australian Lynch-like syndrome patients', Cancer Genetics, 209, pp. 497 - 500, http://dx.doi.org/10.1016/j.cancergen.2016.10.001

Journal articles | 2016

Liu Q; Hesson LB; Nunez AC; Packham D; Williams R; Ward RL; Sloane MA, 2016, 'A cryptic paracentric inversion of MSH2 exons 2-6 causes Lynch syndrome', Carcinogenesis, 37, pp. 10 - 17, http://dx.doi.org/10.1093/carcin/bgv154

Journal articles | 2016

Liu Q; Thompson BA; Ward RL; Hesson LB; Sloane MA, 2016, 'Understanding the Pathogenicity of Noncoding Mismatch Repair Gene Promoter Variants in Lynch Syndrome', Human Mutation, 37, pp. 417 - 426, http://dx.doi.org/10.1002/humu.22971

Journal articles | 2016

Ma S; srivastava S; llamosas E; hawkins N; hesson L; ward R; Ford C, 2016, 'ROR2 is epigenetically inactivated in the early stages of colorectal neoplasia and is associated with proliferation and migration.', BMC Cancer, 16, http://dx.doi.org/10.1186/s12885-016-2576-7

Journal articles | 2016

Ma SSQ; Henry CE; Llamosas E; Higgins R; Daniels B; Hesson LB; Hawkins NJ; Ward RL; Ford CE, 2016, 'Erratum to: Validation of specificity of antibodies for immunohistochemistry: the case of ROR2 (Virchows Archiv, (2016), 10.1007/s00428-016-2019-5)', Virchows Archiv, 469, pp. 717, http://dx.doi.org/10.1007/s00428-016-2036-4

Journal articles | 2016

Sloane MA; Ward RL; Hesson LB, 2016, 'Defining the criteria for identifying constitutional epimutations', Clinical Epigenetics, 8, http://dx.doi.org/10.1186/s13148-016-0207-4

Journal articles | 2016

Srivastava S; Ludwig AK; Wong JWH; Hesson LB, 2016, 'An investigation of the potential for epigenetic inactivation by transcription read-through in a sporadic colorectal cancer', Gene, 585, pp. 154 - 158, http://dx.doi.org/10.1016/j.gene.2016.03.031

Journal articles | 2016

Thoms JAI; Knezevic K; Liu JJ; Glaros EN; Thai T; Qiao Q; Campbell H; Packham D; Huang Y; Papathanasiou P; Tunningley R; Whittle B; Yeung AWS; Chandrakanthan V; Hesson L; Chen V; Wong JWH; Purton LE; Ward RL; Thomas SR; Pimanda JE, 2016, 'Arrested hematopoiesis and vascular relaxation defects in mice with a mutation in Dhfr', Molecular and Cellular Biology, 36, pp. 1222 - 1236, http://dx.doi.org/10.1128/MCB.01035-15

Journal articles | 2016

Youngson N; Lecomte V; Maloney C; Leung P; Liu J; Hesson L; Luciani F; Krause L; Morris M, 2016, 'Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring', Asian Journal of Andrology, 18, pp. 930 - 936, http://dx.doi.org/10.4103/1008-682X.163190

Journal articles | 2015

Hesson LB; Packham D; Kwok CT; Nunez AC; Ng B; Schmidt C; Fields M; Wong JW; Sloane MA; Ward RL, 2015, 'Lynch Syndrome associated with two MLH1 promoter variants and allelic imbalance of MLH1 expression.', Human Mutation, 36, pp. 622 - 630, http://dx.doi.org/10.1002/humu.22785

Journal articles | 2015

Poulos RC; Sloane MA; Hesson LB; Wong JWH, 2015, 'The search for cis-regulatory driver mutations in cancer genomes', Oncotarget, 6, pp. 32509 - 32525, http://dx.doi.org/10.18632/oncotarget.5085

Journal articles | 2015

Sloane MA; Nunez AC; Packham D; Kwok CT; Suthers G; Hesson LB; Ward RL, 2015, 'Mosaic epigenetic inheritance as a cause of early-onset colorectal cancer', JAMA Oncology, 1, pp. 953 - 957, http://dx.doi.org/10.1001/jamaoncol.2015.1484

Journal articles | 2015

Zarzour P; Boelen L; Luciani F; Beck D; Sakthianandeswaren A; Mouradov D; Sieber OM; Hawkins NJ; Hesson LB; Ward RL; Wong JWH, 2015, 'Single nucleotide polymorphism array profiling identifies distinct chromosomal aberration patterns across colorectal adenomas and carcinomas', Genes Chromosomes and Cancer, 54, pp. 303 - 314, http://dx.doi.org/10.1002/gcc.22243

Journal articles | 2014

Hesson LB; Sloane MA; Wong JWH; Nunez AC; Srivastava S; Ng B; Hawkins NJ; Bourke MJ; Ward RL, 2014, 'Altered promoter nucleosome positioning is an early event in gene silencing', Epigenetics, 9, pp. 1422 - 1430, http://dx.doi.org/10.4161/15592294.2014.970077

Journal articles | 2014

Hesson LB; Ward RL, 2014, 'Discrimination of pseudogene and parental gene dna methylation using allelic bisulfite sequencing', Methods in Molecular Biology, 1167, pp. 265 - 274, http://dx.doi.org/10.1007/978-1-4939-0835-6_18

Journal articles | 2014

Hesson LB; Ward RL, 2014, 'The importance of distinguishing pseudogenes from parental genes', Clinical Epigenetics, 6, pp. 90, http://dx.doi.org/10.1186/s13148-014-0033-5

Journal articles | 2014

Patil V; Ward RL; Hesson LB, 2014, 'The evidence for functional non-CpG methylation in mammalian cells', Epigenetics, 9, pp. 823 - 828, http://dx.doi.org/10.4161/epi.28741

Journal articles | 2014

Simar D; Versteyhe S; Donkin I; Liu J; Hesson L; Nylander V; Fossum A; Barres R, 2014, 'DNA Methylation Is Altered In B And NK Lymphocytes In Obese And Type 2 Diabetic Human', Metabolism: clinical and experimental, 63, pp. 1188 - 1197, http://dx.doi.org/10.1016/j.metabol.2014.05.014

Journal articles | 2014

Sloane MA; Hesson LB; Nunez AC; Thompson BA; Ward RL, 2014, 'Nucleosome positioning is unaltered at MLH1 splice site mutations in cells derived from Lynch syndrome patients', Clinical Epigenetics, 6, pp. 32 - 32, http://dx.doi.org/10.1186/preaccept-1571082317134727

Journal articles | 2014

Sloane MA; Hesson LB; Nunez AC; Thompson BA; Ward RL, 2014, 'Nucleosome positioning is unaltered at MLH1 splice site mutations in cells derived from Lynch syndrome patients', Clinical Epigenetics, 6, http://dx.doi.org/10.1186/s13148-014-0032-6

Journal articles | 2014

Sloane MA; Hesson LB; Ward RL, 2014, 'Epimutations and cancer susceptibility', eLS, Published Online: 17 MAR 2014, pp. 1 - 10, http://dx.doi.org/10.1002/9780470015902.a0024615

Journal articles | 2014

Sloane MA; Wong JWH; Perera D; Nunez AC; Pimanda JE; Hawkins NJ; Sieber OM; Bourke MJ; Hesson LB; Ward RL, 2014, 'Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia', Epigenetics, 9, pp. 1092 - 1100, http://dx.doi.org/10.4161/epi.29222

Journal articles | 2013

Hesson L, 2013, 'Gut microbiota and obesity-related gastrointestinal cancer: a focus on epigenetics', Translational Gastrointestinal Cancer, 2, pp. 204 - 210

Journal articles | 2013

Hesson LB; Patil V; Sloane MA; Nunez AC; Liu J; Pimanda JE; Ward RL, 2013, 'Reassembly of Nucleosomes at the MLH1 Promoter Initiates Resilencing Following Decitabine Exposure', PLoS Genetics, 9, http://dx.doi.org/10.1371/journal.pgen.1003636

Journal articles | 2013

Liu J; Hesson LB; Ward RL, 2013, 'Liquid chromatography tandem mass spectrometry for the measurement of global DNA methylation and hydroxymethylation', Journal of Proteomics & Bioinformatics, 01, http://dx.doi.org/10.4172/jpb.S2-005

Journal articles | 2013

Metz AJ; Bourke MJ; Moss A; Dower A; Zarzour P; Hawkins NJ; Ward RL; Hesson L, 2013, 'A correlation of the endoscopic characteristics of colonic laterally spreading tumours (LSTs) with genetic alterations', European Journal of Gastroenterology and Hepatology, 25, pp. 319 - 326, http://dx.doi.org/10.1097/MEG.0b013e32835b57e7

Journal articles | 2013

Zarzour P; Hesson LB; Ward RL, 2013, 'Establishing the clinical utility of epigenetic markers in cancer: Many challenges ahead', Epigenomics, 5, pp. 513 - 523, http://dx.doi.org/10.2217/epi.13.53

Journal articles | 2012

Hesson L; Packham D; Pontzer E; Funchain P; Eng C; Ward RL, 2012, 'A reinvestigation of somatic hypermethylation at the PTEN CpG island in cancer cell lines', Biological Procedures Online, 14, pp. 1 - 8, http://dx.doi.org/10.1186/1480-9222-14-5

Journal articles | 2012

Hesson LB; Wong JWH; Sloane MA; Pimanda JE; Bourke MJ; Hawkins NJ; Ward RL, 2012, 'Nucleosome occupancy at unmethylated promoter CpG islands represents a novel mechanism of epigenetic gene silencing in cancer', CANCER RESEARCH, 72, http://dx.doi.org/10.1158/1538-7445.AM2012-990

Journal articles | 2012

Lau DT; Hesson L; Norris MD; Marshall GM; Haber M; Ashton LJ, 2012, 'Prognostic Significance of Promoter DNA Methylation in Patients with Childhood Neuroblastoma', Clinical Cancer Research, 18, pp. 5690 - 5700, http://dx.doi.org/10.1158/1078-0432.CCR-12-0294

Journal articles | 2012

Lau DT; Hesson LB; Norris MD; Haber M; Marshall GM; Ashton LJ, 2012, 'Prognostic significance of promoter DNA methylation in patients with neuroblastoma', CANCER RESEARCH, 72, http://dx.doi.org/10.1158/1538-7445.AM2012-1425

Journal articles | 2012

Lau DT; Hesson LB; Norris MD; Marshall G; Haber M; Ashton LJ, 2012, 'Abstract 68: Beyond GWAS: The prognostic significance of promoter DNA methylation in patients with neuroblastoma.', Cancer Epidemiology, Biomarkers & Prevention, 21, pp. 68 - 68, http://dx.doi.org/10.1158/1055-9965.gwas-68

Journal articles | 2012

Liu J; Hesson L; Meagher AP; Bourke MJ; Hawkins NJ; Rand KN; Molloy PL; Pimanda JE; Ward RL, 2012, 'Relative distribution of folate species is associated with global DNA methylation in human colorectal mucosa', CANCER PREVENTION RESEARCH, 5, pp. 921 - 929, http://dx.doi.org/10.1158/1940-6207.CAPR-11-0577

Journal articles | 2011

Hesson LB; Latif F, 2011, 'RASSF2 (Ras association (RalGDS/AF-6) domain family member 2)', Atlas of Genetics and Cytogenetics in Oncology and Haematology, http://dx.doi.org/10.4267/2042/44798

Journal articles | 2011

Hesson LB; Latif F, 2011, 'RASSF6 (Ras association (RalGDS/AF-6) domain family member 6)', Atlas of Genetics and Cytogenetics in Oncology and Haematology, http://dx.doi.org/10.4267/2042/44939

Journal articles | 2011

Hesson LB; Patil V; Sloane M; Ward RL, 2011, 'Investigation of the molecular events associated with gene resilencing following withdrawal of epigenetic therapies', CANCER RESEARCH, 71, http://dx.doi.org/10.1158/1538-7445.AM2011-2000

Journal articles | 2011

Liu JJ; Hesson LB; Rand KN; Molloy PL; Pimanda J; Ward RL, 2011, 'Analysis of global and repeat sequence DNA methylation in the blood and normal colonic mucosa of colorectal cancer patients, healthy individuals and patients with folate deficiency', CANCER RESEARCH, 71, http://dx.doi.org/10.1158/1538-7445.AM2011-91

Journal articles | 2010

Dunwell TL; Hesson L; Rauch TA; Wang L; Clark R; Dallol A; Gentle D; Catchpoole DR; Maher ER; Pfeifer G; Latif F, 2010, 'A Genome-wide screen identifies frequently methylated genes in haematological and epithelial cancers', Molecular Cancer, 9, pp. 44 - 44

Journal articles | 2010

Hesson L; Donninger H; Latif F; Vos MD; Beebe K; Gordon L; Sidransky D; Liu JW; Schlegel T; Payne S; Hartmann A, 2010, 'The Ras effector RASSF2 controls the PAR-4 tumor suppressor.', Molecular and Cellular Biology, 30, pp. 2608 - 2620

Journal articles | 2010

Hesson L; Hitchins MP; Ward RL, 2010, 'Epimutations and cancer predisposition: importance and mechanisms', Current Opinion in Genetics and Development, 20, pp. 1 - 9, http://dx.doi.org/10.1016/j.gde.2010.02.005

Journal articles | 2010

Hill VK; Hesson L; Dansranjavin T; Dallol A; Bieche I; Vacher S; Tommasi S; Dobbins TA; Gentle D; Euhus D; Dammann R; Ward RL; Minna JD; Maher ER; Pfeifer G; Latif F, 2010, 'Identification of 5 novel genes methylated in breast and other epithelial cancers', Molecular Cancer Research, 9, pp. 51 - 66, http://dx.doi.org/10.1186/1476-4598-9-51

Journal articles | 2010

Lock FE; Underhill-Day N; Dunwell TL; Matallanas D; Cooper W; Hesson L; Recino A; Ward A; Pavlova TV; Zabarovsky ER; Grant M; Maher ER; Chalmers AD; Kolch W; Latif F, 2010, 'The RASSF8 candidate tumor suppressor inhibits cell growth and regulates the Wnt and NF-kB signaling pathways', Oncogene, 29, pp. 4307 - 4316

Journal articles | 2009

Cooper W; Hesson L; Matallanas D; Dallol A; Von Kriegsheim A; Ward RL; Kolch W; Latif F, 2009, 'RASSF2 associates with and stabilizes the proapoptotic kinase MST2', Oncogene, 28, pp. 2988 - 2998, http://dx.doi.org/10.1038/onc.2009.152

Journal articles | 2009

Dallol A; Hesson L; Matallanas D; Cooper WN; O''neill E; Maher ER; Kolch W; Latif F, 2009, 'Ran GTPase is a RASSF1A effector involved in controlling microtubule organisation', Ran GTPase is a RASSF1A effector involved in controlling microtubule organisation, 19, pp. 1227 - 1232

Journal articles | 2009

Dunwell TL; Hesson L; Pavlova TV; Zabarovska V; Kashuba V; Catchpoole DR; Chiaramonte R; Brini AT; Griffiths M; Maher ER; Zabarovsky ER; Latif F, 2009, 'Epigenetic analysis of childhood acute lymphoblastic leukemia', Epigenetic analysis of childhood acute lymphoblastic leukemia, 4, pp. 185 - 193

Journal articles | 2009

Hesson L; Dunwell TL; Cooper WN; Catchpoole DR; Brini AT; Chiaramonte R; Chalmers AD; Griffiths M; Maher ER; Latif F, 2009, 'The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias', Molecular Cancer, 8, pp. 42 - 42

Journal articles | 2008

Cooper WN; Dickinson RE; Dallol A; Hesson LB; Bieche I; Clark GJ; Maher ER; Zabarovsky ER; Latif F, 2008, 'RASSF2 can suppress the growth of breast cancer cell lines and is epigenetically inactivated in breast tumours', Breast Cancer Research, 10, http://dx.doi.org/10.1186/bcr1893

Journal articles | 2008

Hesson L; Krex D; Latif F, 2008, 'Epigenetic markers of human gliomas – prospects for therapeutic intervention', Expert Review of Neurotherapeutics, 8, pp. 1475 - 1496

Journal articles | 2008

Morton S; Hesson L; Peggie M; Cohen P, 2008, 'Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma.', FEBS Letters, 582, pp. 997 - 1002

Journal articles | 2007

Allen NPC; Donninger H; Vos MD; Eckfeld K; Hesson L; Gordon L; Birrer MJ; Latif F; Clark GJ, 2007, 'RASSF6 is a novel member of the RASSF family of tumor suppressors.', Oncogene, 26, pp. 6203 - 6211

Journal articles | 2007

Cooper WN; Dickinson RE; Dallol A; Grigorieva EV; Pavlova TV; Hesson L; Bieche I; Broggini M; Maher ER; Zabarovsky ER; Clark GJ; Latif F, 2007, 'Epigenetic regulation of the ras effector/tumour suppressor RASSF2 in breast and lung cancer', Oncogene, 27, pp. 1805 - 1811

Journal articles | 2007

Hesson L; Cooper WN; Latif F, 2007, 'Evaluation of the 3p21.3 Tumour-suppressor Gene Cluster', Oncogene, 26, pp. 7283 - 7301

Journal articles | 2007

Hesson L; Cooper WN; Latif F, 2007, 'The role of RASSF1A methylation in cancer', Disease Markers, 23, pp. 73 - 87

Journal articles | 2006

Vos MD; Dallol A; Eckfeld K; Allen NPC; Donninger H; Hesson L; Calvisi D; Latif F; Clark GJ, 2006, 'The RASSF1A tumor suppressor activates Bax via MOAP-1', The Journal of Biological Chemistry, 281, pp. 4557 - 4563

Journal articles | 2005

Caren H; Ejeskar K; Fransson S; Hesson L; Latif F; Sjoberg RM; Krona C; Martinsson T, 2005, 'A cluster of genes located in 1p36 are down-regulated in neuroblastomas with poor prognosis, but not due to CpG island methylation', Molecular Cancer, 4, pp. 10

Journal articles | 2005

Elam C; Hesson L; Vos MD; Eckfeld K; Ellis CA; Bell A; Krex D; Birrer MJ; Latif F; Clark GJ, 2005, 'RRP22 is a farnesylated, nucleolar, Ras-related protein with tumor suppressor potential', Cancer research, 65, pp. 3117 - 3125

Journal articles | 2005

Hesson L; Wilson R; Morton D; Walker M; Maher ER; Latif F, 2005, 'CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations', Oncogene, 24, pp. 3987 - 3994

Journal articles | 2004

Dallol A; Agathanggelou A; Fenton SL; Hesson L; Ahmed-choudhury J; Vos MD; Clark GJ; Downward J; Maher ER; Latif F, 2004, 'RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics', Cancer research, 64, pp. 4112 - 4116

Journal articles | 2004

Eckfeld K; Hesson L; Vos MD; Bieche I; Latif F; Clark GJ, 2004, 'RASSF4/AD037 is a potential ras effector/tumor suppressor of the RASSF family', Cancer research, 64, pp. 8688 - 8693

Journal articles | 2004

Fenton SL; Dallol A; Agathanggelou A; Hesson L; Ahmed-choudhury J; Baksh S; Sardet C; Dammann R; Minna JD; Downward J; Maher ER; Latif F, 2004, 'Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene', Cancer research, 64, pp. 102 - 107

Journal articles | 2004

Hesson L; Bieche I; Krex D; Criniere E; Hoang-xuan K; Maher ER; Latif F, 2004, 'Frequent epigenetic inactivation of RASSF1A and BLU genes located within the critical 3p21.3 region in gliomas', Oncogene, 23, pp. 2408 - 2419

Journal articles | 2003

Agathanggelou A; Dallol A; Zochbauer-muller S; Morrissey C; Honorio S; Hesson L; Martinsson T; Fong KM; Kuo MJ; Yuen PW; Maher ER; Minna JD; Latif F, 2003, 'Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU in human cancers', Oncogene, 22, pp. 1580 - 1588

Journal articles | 2003

Da silva NF; Gentle D; Hesson L; Morton D; Latif F; Maher ER, 2003, 'Analysis of the Birt-Hogg-Dube (BHD) tumour suppressor gene in sporadic renal cell carcinoma and colorectal cancer', Journal of Medical Genetics, 40, pp. 820 - 824

Journal articles | 2003

Dallol A; Krex D; Hesson L; Eng C; Maher ER; Latif F, 2003, 'Frequent epigenetic inactivation of the SLIT2 gene in gliomas', Oncogene, 22, pp. 4611 - 4616

Journal articles | 2003

Hesson L; Dallol A; Minna JD; Maher ER; Latif F, 2003, 'NORE1A, a homologue of RASSF1A tumour suppressor gene is inactivated in human cancers', Oncogene, 22, pp. 947 - 954

Journal articles | 2003

Morris MR; Hesson L; Wagner KJ; Morgan NV; Astuti D; Lees RD; Cooper WN; Lee J; Gentle D; Macdonald F; Kishida T; Grundy R; Yao M; Latif F; Maher ER, 2003, 'Multigene methylation analysis of Wilms' tumour and adult renal cell carcinoma', Oncogene, 22, pp. 6794 - 6801
Preprints | 2023

Saya S; Chondros P; Abela A; Mihalopolous C; Chatterton ML; Gunn J; Chen TF; Polasek TM; Dettmann E; Brooks R; King M; Spencer L; Alphonse P; Milton S; Ramsay G; Siviour Z; Liew JJM; Ly P; Thoenig M; Seychell R; Rocca FL; Hesson LB; Mejias N; Sivertsen T; Galea MA; Bousman C; Emery J, 2023, The PRESIDE (PhaRmacogEnomicS In DEpression) Trial: a double-blind randomised controlled trial of pharmacogenomic-informed prescribing of antidepressants on depression outcomes in patients with major depressive disorder in primary care., , http://dx.doi.org/10.21203/rs.3.rs-2840416/v1

Preprints | 2018

Poulos R; Perera D; Packham D; Shah A; Janitz C; Pimanda J; Hawkins N; Ward R; Hesson L; Wong JWH, 2018, In search of non-coding driver mutations by deep sequencing of regulatory elements in colorectal cancer, , http://dx.doi.org/10.1101/249300

Conference Abstracts | 2017

Unnikrishnan A; Quynh AVN; Pickford R; Nunez A; Hesson L; Pimanda J, 2017, 'A NOVEL MASS SPECTROMETRY METHOD REVEALS THE INTRACELLULAR PHARMACOKINETICS OF AZACYTIDINE THERAPY IN VIVO', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, SPAIN, Madrid, Vol. 102, pp. 258 - 259, presented at 22nd Congress of the European-Hematology-Association, SPAIN, Madrid, 22 June 2017 - 25 June 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000404127002145&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A; Villanueva JE; Nunez AC; Knezevic K; Palu C; Nasrallah R; Carnell M; Macmillan A; Whan R; Yu Y; Hardy P; Grey ST; Gladbach A; Delerue F; Ittner L; Mobbs R; Walkley CR; Purton LE; Ward RL; Wong JWH; Hesson LB; Walsh W; Pimanda JE, 2016, 'PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 113, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113

Conference Abstracts | 2015

Sloane M; Liu Q; Nunez A; Packham D; Kwok C-T; Suthers G; Du Sart D; Williams R; Hesson L; Ward R, 2015, 'TRANSLATING BASIC RESEARCH INTO THE CLINICAL MANAGEMENT OF FAMILIES WITH LYNCH SYNDROME', in Asia-Pacific Journal of Clinical Oncology, WILEY-BLACKWELL, Vol. 11, pp. 102 - 102, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000364320800126&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2013

Patil V; Sloane MA; Wong JW; Liu J; Ward RL; Hesson LB, 2013, 'Abstract 2983: Gene resilencing following decitabine therapy is initiated by nucleosome reoccupancy and is related to CpG island shore methylation.', in Cancer Research, American Association for Cancer Research (AACR), pp. 2983 - 2983, presented at Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC, http://dx.doi.org/10.1158/1538-7445.am2013-2983

Conference Abstracts | 2012

Liu J; Hesson LB; Meagher AP; Bourke MJ; Hawkins NJ; Rand KN; Molloy PL; Pimanda JE; Ward RL, 2012, 'Relative distribution of folate species is associated with global DNA methylation in human colorectal mucosa', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 72, http://dx.doi.org/10.1158/1538-7445.AM2012-3125

Conference Papers | 2012

Sloane M; Hesson L; Wong J; Pimanda J; Bourke M; Hawkins N; Ward R, 2012, 'Inactivation of the deubiquitinase USP44 is an early event in the formation of colorectal cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM2012-LB-375

Conference Papers | 2011

Metz AJ; Bourke MJ; Moss A; Hesson L; Ward R, 2011, 'A Correlation of the Endoscopic Characteristics of Colonic Laterally Spreading Tumours (LSTS) With Genetic Mutations', in GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, IL, Chicago, pp. S191 - S191, presented at Conference on Digestive Disease Week 2011, IL, Chicago, 07 May 2011 - 10 May 2011, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000290167300770&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2010

Hill V; Hesson L; Dansranjavin T; Dallol A; Bieche I; Tommasi S; Dobbins T; Gentle D; Euhus D; Dammann R; Ward RL; Minna J; Maher ER; Pfeifer G; Latif F, 2010, 'MIRA (methylated CpG island recovery assay) assay identifies frequently methylated genes in breast cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM10-165

Conference Posters | 2010

Metz AJ; Bourke MJ; Moss A; Hesson L; Ward R, 2010, 'A correlation of the endoscopic characteristics of colonic laterally spreading tumours (LSTs) with genetic mutations', Vol. 25, pp. A78 - A78, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000283321200212&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Awarded $4M AUD in funding as Chief Investigator.

Co-Chief Investigator, Harnessing the power from within: Neoantigen immunopeptidomics for the development of immunotherapies for the treatment of diffuse intrinsic pontine glioma (DIPG) (2020-2023), $326,389

Project Lead, MTPConnect, BioMedTech Horizons Project, A clinically-accredited and commercial-ready genome profiling platform to enable precision cancer medicine (2018-2020), $1,817,678

Consortium Lead, MTPConnect, Enabling Precision Cancer Clinical Trials (2018-2020), $828,540

Co-Chief Investigator, Anthony Rothe Memorial Trust (2016-2017), $200,000

Co-Chief Investigator, Big Data Big Impact Grant, Cancer Institute New South Wales (2013-2014), $210,000

Co-applicant, UNSW Faculty Research Grant (2012), $20,000

Chief Investigator, Cancer Institute New South Wales Fellowship (2010-2012), $599,883

Breast Cancer Campaign UK the Team of the Year 2004 Prize, awarded in a ceremony at The House of Lords, Westminster, London.

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Associate Professor Luke Hesson