Lars Ittner

Adjunct Professor

Professor Lars Ittner's research focuses on understanding disease mechanisms in neurodegeneration and developing novel therapeutic approaches to overcome dementia. For more information, visit the Dementia Research Unit homepage (https://medicalsciences.med.unsw.edu.au/research/groups/dementia-research-unit).

Publications

Journal articles
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Martin AD; Wojciechowski JP; Du EY; Rawal A; Stefen H; Au CG; Hou L; Cranfield CG; Fath T; Ittner LM; Thordarson P, 2020, 'Decoupling the effects of hydrophilic and hydrophobic moieties at the neuron-nanofibre interface', Chemical Science, vol. 11, pp. 1375 - 1382, http://dx.doi.org/10.1039/c9sc05686f
2020
Watt G; Przybyla M; Zak V; van Eersel J; Ittner A; Ittner LM; Karl T, 2020, 'Novel Behavioural Characteristics of Male Human P301S Mutant Tau Transgenic Mice – A Model for Tauopathy', Neuroscience, vol. 431, pp. 166 - 175, http://dx.doi.org/10.1016/j.neuroscience.2020.01.047
2020
Werry EL; Bright FM; Piguet O; Ittner LM; Halliday GM; Hodges JR; Kiernan MC; Loy CT; Kril JJ; Kassiou M, 2019, 'Recent developments in TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders', International Journal of Molecular Sciences, vol. 20, http://dx.doi.org/10.3390/ijms20133161
2019
Ke YD; Chan G; Stefanoska K; Au C; Bi M; Müller J; Przybyla M; Feiten A; Prikas E; Halliday GM; Piguet O; Kiernan MC; Kassiou M; Hodges JR; Loy CT; Mattick JS; Ittner A; Kril JJ; Sutherland GT; Ittner LM, 2019, 'CNS cell type-specific gene profiling of P301S tau transgenic mice identifies genes dysregulated by progressive tau accumulation', Journal of Biological Chemistry, vol. 294, pp. 14149 - 14162, http://dx.doi.org/10.1074/jbc.RA118.005263
2019
Cheng HWA; Sokias R; Werry EL; Ittner LM; Reekie TA; Du J; Gao Q; Hibbs DE; Kassiou M, 2019, 'First Nondiscriminating Translocator Protein Ligands Produced from a Carbazole Scaffold', Journal of Medicinal Chemistry, vol. 62, pp. 8235 - 8248, http://dx.doi.org/10.1021/acs.jmedchem.9b00980
2019
Brettle M; Stefen H; Djordjevic A; Fok SYY; Chan JW; van Hummel A; van der Hoven J; Przybyla M; Volkerling A; Ke YD; Delerue F; Ittner LM; Fath T, 2019, 'Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice', Frontiers in Molecular Neuroscience, vol. 12, http://dx.doi.org/10.3389/fnmol.2019.00231
2019
Ittner LM; Klugmann M; Ke YD, 2019, 'Adeno-associated virus-based Alzheimer's disease mouse models and potential new therapeutic avenues', British Journal of Pharmacology, vol. 176, pp. 3649 - 3665, http://dx.doi.org/10.1111/bph.14637
2019
Lei M; Teo JD; Song H; McEwen HP; Yup Lee J; Couttas TA; Duncan T; Chesworth R; Bertz J; Przybyla M; Van Eersel J; Heng B; Guillemin GJ; Ittner LM; Fath T; Garner B; Ittner A; Karl T; Don AS, 2019, 'Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease', The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 39, pp. 9645 - 9659, http://dx.doi.org/10.1523/JNEUROSCI.0524-19.2019
2019
Bright F; Werry EL; Dobson-Stone C; Piguet O; Ittner LM; Halliday GM; Hodges JR; Kiernan MC; Loy CT; Kassiou M; Kril JJ, 2019, 'Neuroinflammation in frontotemporal dementia', Nature Reviews Neurology, vol. 15, pp. 540 - 555, http://dx.doi.org/10.1038/s41582-019-0231-z
2019
Zhao Y; Keshiya S; Atashrazm F; Gao J; Ittner LM; Alessi DR; Halliday GM; Fu Y; Dzamko N, 2018, 'Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice', Neurobiology of Disease, vol. 120, pp. 76 - 87, http://dx.doi.org/10.1016/j.nbd.2018.09.003
2018
Stefanoska K; Bertz J; Volkerling AM; van der Hoven J; Ittner LM; Ittner A, 2018, 'Neuronal MAP kinase p38α inhibits c-Jun N-terminal kinase to modulate anxiety-related behaviour', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-32592-y
2018
Ittner LM; Lee WS; Stefanoska K; Asih PR; Ke YD, 2018, 'Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Mouse Models', in NeurodegeneratIve Diseases: Clinical Aspects, Molecular Genetics and Biomarkers, pp. 187 - 219, http://dx.doi.org/10.1007/978-3-319-72938-1_10
2018
Forrest SL; Kril JJ; Stevens CH; Kwok JB; Hallupp M; Kim WS; Huang Y; McGinley CV; Werka H; Kiernan MC; Götz J; Spillantini MG; Hodges JR; Ittner LM; Halliday GM, 2018, 'Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies', Brain, vol. 141, pp. 521 - 534, http://dx.doi.org/10.1093/brain/awx328
2018
Martin AD; Chua SW; Au CG; Stefen H; Przybyla M; Lin Y; Bertz J; Thordarson P; Fath T; Ke YD; Ittner LM, 2018, 'Peptide Nanofiber Substrates for Long-Term Culturing of Primary Neurons', ACS Applied Materials and Interfaces, vol. 10, pp. 25127 - 25134, http://dx.doi.org/10.1021/acsami.8b07560
2018
Ittner A; Ittner LM, 2018, 'Dendritic Tau in Alzheimer's Disease', Neuron, vol. 99, pp. 13 - 27, http://dx.doi.org/10.1016/j.neuron.2018.06.003
2018
Stefanoska K; Volkerling A; Bertz J; Poljak A; Ke YD; Ittner LM; Ittner A, 2018, 'An N-terminal motif unique to primate tau enables differential protein–protein interactions', Journal of Biological Chemistry, vol. 293, pp. 3710 - 3719, http://dx.doi.org/10.1074/jbc.RA118.001784
2018
Tan DCS; Yao S; Ittner A; Bertz J; Ke YD; Ittner LM; Delerue F, 2018, 'Generation of a New Tau Knockout (tau Δex1) Line Using CRISPR/Cas9 Genome Editing in Mice', Journal of Alzheimer's Disease, vol. 62, pp. 571 - 578, http://dx.doi.org/10.3233/JAD-171058
2018
Forrest SL; Kril JJ; Stevens CH; Kwok JB; Hallupp M; Kim WS; Huang Y; McGinley CV; Werka H; Kiernan MC; Gotz J; Spillantini MG; Hodges JR; Ittner LM; Halliday GM, 2018, 'Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies (vol 141, pg 521, 2018)', BRAIN, vol. 141, http://dx.doi.org/10.1093/brain/awy012
2018
Ahmed RM; Ke YD; Vucic S; Ittner LM; Seeley W; Hodges JR; Piguet O; Halliday G; Kiernan MC, 2018, 'Physiological changes in neurodegeneration-mechanistic insights and clinical utility', Nature Reviews Neurology, vol. 14, pp. 259 - 271, http://dx.doi.org/10.1038/nrneurol.2018.23
2018
Ke YD; Ittner LM, 2018, 'Epothilone D – correct drug, wrong disease', Neuropathology and Applied Neurobiology, vol. 44, pp. 548 - 549, http://dx.doi.org/10.1111/nan.12478
2018
Aldilla VR; Martin AD; Nizalapur S; Marjo CE; Rich AM; Ho KKK; Ittner LM; Black DSC; Thordarson P; Kumar N, 2018, 'Glyoxylamide-based self-assembly hydrogels for sustained ciprofloxacin delivery', Journal of Materials Chemistry B, vol. 6, pp. 6089 - 6098, http://dx.doi.org/10.1039/C8TB01290C
2018
Bodea L-G; Evans HT; Van der Jeugd A; Ittner LM; Delerue F; Kril J; Halliday G; Hodges J; Kiernan MC; Gotz J, 2018, 'Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model (vol 16, 377, 2017)', AGING CELL, vol. 17, http://dx.doi.org/10.1111/acel.12712
2018
van Hummel A; Chan G; van der Hoven J; Morsch M; Ippati S; Suh L; Bi M; Asih PR; Lee WS; Butler TA; Przybyla M; Halliday GM; Piguet O; Kiernan MC; Chung RS; Ittner LM; Ke YD, 2018, 'Selective Spatiotemporal Vulnerability of Central Nervous System Neurons to Pathologic TAR DNA-Binding Protein 43 in Aged Transgenic Mice', American Journal of Pathology, vol. 188, pp. 1447 - 1456, http://dx.doi.org/10.1016/j.ajpath.2018.03.002
2018
Hafezi F; Gatzioufas Z; Angunawela R; Ittner LM, 2018, 'Absence of IL-6 prevents corneal wound healing after deep excimer laser ablation in vivo', Eye (Basingstoke), vol. 32, pp. 156 - 157, http://dx.doi.org/10.1038/eye.2017.238
2018
von Jonquieres G; Spencer ZHT; Rowlands BD; Klugmann CB; Bongers A; Harasta AE; Parley KE; Cederholm J; Teahan O; Pickford R; Delerue F; Ittner LM; Fröhlich D; McLean CA; Don AS; Schneider M; Housley GD; Rae CD; Klugmann M, 2018, 'Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy', Acta Neuropathologica, vol. 135, pp. 95 - 113, http://dx.doi.org/10.1007/s00401-017-1784-9
2018
Asih PR; Tegg ML; Sohrabi H; Carruthers M; Gandy SE; Saad F; Verdile G; Ittner LM; Martins RN, 2017, 'Multiple Mechanisms Linking Type 2 Diabetes and Alzheimer's Disease: Testosterone as a Modifier', Journal of Alzheimer's Disease, vol. 59, pp. 445 - 466, http://dx.doi.org/10.3233/JAD-161259
2017
Moujalled D; Grubman A; Acevedo K; Yang S; Ke YD; Moujalled DM; Duncan C; Caragounis A; Perera ND; Turner BJ; Prudencio M; Petrucelli L; Blair I; Ittner LM; Crouch PJ; Liddell JR; White AR, 2017, 'TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway', Human Molecular Genetics, vol. 26, pp. 1732 - 1746, http://dx.doi.org/10.1093/hmg/ddx093
2017
Bodea LG; Evans HT; Van der Jeugd A; Ittner LM; Delerue F; Kril J; Halliday G; Hodges J; Kiernan MC; Götz J, 2017, 'Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model', Aging Cell, vol. 16, pp. 377 - 386, http://dx.doi.org/10.1111/acel.12565
2017
Bharadwaj P; Wijesekara N; Liyanapathirana M; Newsholme P; Ittner L; Fraser P; Verdile G, 2017, 'The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-β, Amylin, and Tau Proteins', Journal of Alzheimer's Disease, vol. 59, pp. 421 - 432, http://dx.doi.org/10.3233/JAD-161192
2017
Harasta AE; Ittner LM, 2017, 'Alzheimer’s disease: Insights from genetic mouse models and current advances in human IPSC-derived neurons', Advances in Neurobiology, vol. 15, pp. 3 - 29, http://dx.doi.org/10.1007/978-3-319-57193-5_1
2017
Bi M; Gladbach A; Van Eersel J; Ittner A; Przybyla M; Van Hummel A; Chua SW; Hoven JVD; Lee WS; Müller J; Parmar J; Jonquieres GV; Stefen H; Guccione E; Fath T; Housley GD; Klugmann M; Ke YD; Ittner LM, 2017, 'Tau exacerbates excitotoxic brain damage in an animal model of stroke', Nature Communications, vol. 8, http://dx.doi.org/10.1038/s41467-017-00618-0
2017
Fröhlich D; Suchowerska AK; Spencer ZHT; von Jonquieres G; Klugmann CB; Bongers A; Delerue F; Stefen H; Ittner LM; Fath T; Housley GD; Klugmann M, 2017, 'In vivo characterization of the aspartyl-tRNA synthetase DARS: Homing in on the leukodystrophy HBSL', Neurobiology of Disease, vol. 97, pp. 24 - 35, http://dx.doi.org/10.1016/j.nbd.2016.10.008
2017
Sokias R; Werry EL; Chua SW; Reekie TA; Munoz L; Wong ECN; Ittner LM; Kassiou M, 2017, 'Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination', MedChemComm, vol. 8, pp. 202 - 210, http://dx.doi.org/10.1039/c6md00523c
2017
Chua SW; Cornejo A; Van Eersel J; Stevens CH; Vaca I; Cueto M; Kassiou M; Gladbach A; Macmillan A; Lewis L; Whan R; Ittner LM, 2017, 'The Polyphenol Altenusin Inhibits in Vitro Fibrillization of Tau and Reduces Induced Tau Pathology in Primary Neurons', ACS Chemical Neuroscience, vol. 8, pp. 743 - 751, http://dx.doi.org/10.1021/acschemneuro.6b00433
2017
harasta AE; ittner LM, 2017, 'Alzheimer’s Disease: Insights from genetic mouse models and current advances in human IPSC-derived neurons', in Beart P; Robinson M; Rattray M ; Maragakis NJ (ed.), Neurodegenerative Diseases Pathology, Mechanisms, and Potential Therapeutic Targets, Springer, pp. 3 - 20, https://link.springer.com/chapter/10.1007/978-3-319-57193-5_1
2017
Pleines I; Woods J; Chappaz S; Kew V; Foad N; Ballester-Beltrán J; Aurbach K; Lincetto C; Lane RM; Schevzov G; Alexander WS; Hilton DJ; Astle WJ; Downes K; Nurden P; Westbury SK; Mumford AD; Obaji SG; Collins PW; BioResource N; Delerue F; Ittner LM; Bryce NS; Holliday M; Lucas CA; Hardeman EC; Ouwehand WH; Gunning PW; Turro E; Tijssen MR; Kile BT, 2017, 'Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia', Journal of Clinical Investigation, vol. 127, pp. 814 - 829, http://dx.doi.org/10.1172/JCI86154
2017
Tan RH; Ke YD; Ittner LM; Halliday GM, 2017, 'ALS/FTLD: experimental models and reality', Acta Neuropathologica, vol. 133, pp. 177 - 196, http://dx.doi.org/10.1007/s00401-016-1666-6
2017
Ittner A; Chua SW; Bertz J; Volkerling A; van der Hoven J; Gladbach A; Przybyla M; Bi M; van Hummel A; Stevens CH; Ippati S; Suh LS; Macmillan A; Sutherland G; Kril JJ; Silva APG; Mackay JP; Poljak A; Delerue F; Ke YD; Ittner LM, 2017, 'Site-specific phosphorylation of tau inhibits amyloid-beta toxicity in Alzheimer's mice (vol 354, 904, 2016)', SCIENCE, vol. 355, http://dx.doi.org/10.1126/science.aam9523
2017
Tan RH; Kril JJ; Yang Y; Tom N; Hodges JR; Villemagne VL; Rowe CC; Leyton CE; Kwok JBJ; Ittner LM; Halliday GM, 2017, 'Assessment of amyloid β in pathologically confirmed frontotemporal dementia syndromes', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 9, pp. 10 - 20, http://dx.doi.org/10.1016/j.dadm.2017.05.005
2017
Ahmed RM; Irish M; van Eersel J; Ittner A; Ke YD; Volkerling A; van der Hoven J; Tanaka K; Karl T; Kassiou M; Kril JJ; Piguet O; Götz J; Kiernan MC; Halliday GM; Hodges JR; Ittner LM, 2017, 'Mouse models of frontotemporal dementia: A comparison of phenotypes with clinical symptomatology', Neuroscience and Biobehavioral Reviews, vol. 74, pp. 126 - 138, http://dx.doi.org/10.1016/j.neubiorev.2017.01.004
2017
Moir M; Chua SW; Reekie T; Martin AD; Ittner A; Ittner LM; Kassiou M, 2017, 'Ring-opened aminothienopyridazines as novel tau aggregation inhibitors', MedChemComm, vol. 8, pp. 1275 - 1282, http://dx.doi.org/10.1039/c6md00306k
2017
Delerue F; Ittner LM, 2017, 'Generation of genetically modified mice through the microinjection of oocytes', Journal of Visualized Experiments, vol. 2017, http://dx.doi.org/10.3791/55765
2017
Ahmed RM; Irish M; Piguet O; Halliday GM; Ittner LM; Farooqi S; Hodges JR; Kiernan MC, 2016, 'Amyotrophic lateral sclerosis and frontotemporal dementia: distinct and overlapping changes in eating behaviour and metabolism', The Lancet Neurology, vol. 15, pp. 332 - 342, http://dx.doi.org/10.1016/S1474-4422(15)00380-4
2016
Ahmed RM; Devenney EM; Irish M; Ittner A; Naismith S; Ittner LM; Rohrer JD; Halliday GM; Eisen A; Hodges JR; Kiernan MC, 2016, 'Neuronal network disintegration: Common pathways linking neurodegenerative diseases', Journal of Neurology, Neurosurgery and Psychiatry, vol. 87, pp. 1234 - 1241, http://dx.doi.org/10.1136/jnnp-2014-308350
2016
Rosa E; Mahendram S; Ke YD; Ittner LM; Ginsberg SD; Fahnestock M, 2016, 'Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease', Neurobiology of Aging, vol. 48, pp. 135 - 142, http://dx.doi.org/10.1016/j.neurobiolaging.2016.08.020
2016
Burrell JR; Halliday GM; Kril JJ; Ittner LM; Götz J; Kiernan MC; Hodges JR, 2016, 'The frontotemporal dementia-motor neuron disease continuum', The Lancet, vol. 388, pp. 919 - 931, http://dx.doi.org/10.1016/S0140-6736(16)00737-6
2016
Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A; Villanueva JE; Nunez AC; Knezevic K; Palu C; Nasrallah R; Carnell M; Macmillan A; Whan R; Yu Y; Hardy P; Grey ST; Gladbach A; Delerue F; Ittner L; Mobbs R; Walkley CR; Purton LE; Ward RL; Wong JWH; Hesson LB; Walsh W; Pimanda JE, 2016, 'PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 113, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113
2016
Przybyla M; Stevens CH; van der Hoven J; Harasta A; Bi M; Ittner A; van Hummel A; Hodges JR; Piguet O; Karl T; Kassiou M; Housley GD; Ke YD; Ittner LM; Eersel JV, 2016, 'Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia', Neuroscience Letters, vol. 631, pp. 24 - 29, http://dx.doi.org/10.1016/j.neulet.2016.08.007
2016
Delerue F; Ittner L, 2016, 'A fast, easy and reliable method for the generation of KO mice using CRISPR/Cas9 by a single person: a small laboratory perspective', in TRANSGENIC RESEARCH, SPRINGER, Vol. 25, pp. 228 - 229, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000371155900079&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2016
Morris GP; Wright AL; Tan RP; Gladbach A; Ittner LM; Vissel B, 2016, 'A comparative study of variables influencing ischemic injury in the longa and koizumi methods of intraluminal filament middle cerebral artery occlusion in mice', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0148503
2016
Ittner A; Chua SW; Bertz J; Volkerling A; Van Der Hoven J; Gladbach A; Przybyla M; Bi M; Van Hummel A; Stevens CH; Ippati S; Suh LS; Macmillan A; Sutherland G; Kril JJ; Silva APG; Mackay J; Poljak A; Delerue F; Ke YD; Ittner LM, 2016, 'Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice', Science, vol. 354, pp. 904 - 908, http://dx.doi.org/10.1126/science.aah6205
2016
Van Hummel A; Bi M; Ippati S; Van Der Hoven J; Volkerling A; Lee WS; Tan DCS; Bongers A; Ittner A; Ke YD; Ittner LM, 2016, 'No overt deficits in aged tau-deficient C57Bl/6.Mapttm1(EGFP)kit GFP knockin mice', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0163236
2016
Shibuya K; Park SB; Geevasinga N; Menon P; Howells J; Simon NG; Huynh W; Noto YI; Götz J; Kril JJ; Ittner LM; Hodges J; Halliday G; Vucic S; Kiernan MC, 2016, 'Motor cortical function determines prognosis in sporadic ALS', Neurology, vol. 87, pp. 513 - 520, http://dx.doi.org/10.1212/WNL.0000000000002912
2016
Tan R; Kril J; Yang Y; Piguet O; Ittner L; Kwok J; Hodges J; Halliday G, 2016, 'Prevalence of amyloid pathology and PiB positivity in frontotemporal dementia', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, Munich, GERMANY, Vol. 138, pp. 335 - 335, presented at 10th International Conference on Frontotemporal Dementias, Munich, GERMANY, 31 August 2016 - 02 September 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000382568400290&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2016
Bodea LG; Eckert A; Ittner LM; Piguet O; Götz J, 2016, 'Tau physiology and pathomechanisms in frontotemporal lobar degeneration', Journal of Neurochemistry, pp. 71 - 94, http://dx.doi.org/10.1111/jnc.13600
2016
Leshchyns'Ka I; Liew HT; Shepherd C; Halliday GM; Stevens CH; Ke YD; Ittner LM; Sytnyk V, 2015, 'Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease', Nature Communications, vol. 6, http://dx.doi.org/10.1038/ncomms9836
2015
Narlawar R; Werry EL; Scarf AM; Hanani R; Chua SW; King VA; Barron ML; Martins RN; Ittner LM; Rendina LM; Kassiou M, 2015, 'First demonstration of positive allosteric-like modulation at the human wild type translocator protein (TSPO)', Journal of Medicinal Chemistry, vol. 58, pp. 8743 - 8749, http://dx.doi.org/10.1021/acs.jmedchem.5b01288
2015
Purushothuman S; Johnstone DM; Nandasena C; van Eersel J; Ittner LM; Mitrofanis J; Stone J, 2015, 'Near infrared light mitigates cerebellar pathology in transgenic mouse models of dementia', Neuroscience Letters, vol. 591, pp. 155 - 159, http://dx.doi.org/10.1016/j.neulet.2015.02.037
2015
van Eersel J; Stevens CH; Przybyla M; Gladbach A; Stefanoska K; Chan CKX; Ong WY; Hodges JR; Sutherland GT; Kril JJ; Abramowski D; Staufenbiel M; Halliday GM; Ittner LM, 2015, 'Early-onset axonal pathology in a novel P301S-Tau transgenic mouse model of frontotemporal lobar degeneration', Neuropathology and Applied Neurobiology, vol. 41, pp. 906 - 925, http://dx.doi.org/10.1111/nan.12233
2015
Verdile G; Asih PR; Barron AM; Wahjoepramono EJ; Ittner LM; Martins RN, 2015, 'The impact of luteinizing hormone and testosterone on beta amyloid (Aβ) accumulation: Animal and human clinical studies', Hormones and Behavior, vol. 76, pp. 81 - 90, http://dx.doi.org/10.1016/j.yhbeh.2015.05.020
2015
Ittner LM; Halliday GM; Kril JJ; Götz J; Hodges JR; Kiernan MC, 2015, 'FTD and ALS-translating mouse studies into clinical trials', Nature Reviews Neurology, vol. 11, pp. 360 - 366, http://dx.doi.org/10.1038/nrneurol.2015.65
2015
Ke YD; van Hummel A; Stevens CH; Gladbach A; Ippati S; Bi M; Lee WS; Krüger S; van der Hoven J; Volkerling A; Bongers A; Halliday G; Haass NK; Kiernan M; Delerue F; Ittner LM, 2015, 'Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS', Acta Neuropathologica, vol. 130, pp. 661 - 678, http://dx.doi.org/10.1007/s00401-015-1486-0
2015
Brettle M; Suchowerska AK; Chua SW; Ittner LM; Fath T, 2015, 'Amyotrophic lateral sclerosis-associated mutant profilin 1 increases dendritic arborisation and spine formation in primary hippocampal neurons', Neuroscience Letters, vol. 609, pp. 223 - 228, http://dx.doi.org/10.1016/j.neulet.2015.09.034
2015
Ittner A; Bertz J; Suh LS; Stevens CH; Götz J; Ittner LM, 2015, 'Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice', Journal of Neurochemistry, vol. 132, pp. 135 - 145, http://dx.doi.org/10.1111/jnc.12821
2015
Nisbet RM; Polanco JC; Ittner LM; Götz J, 2015, 'Tau aggregation and its interplay with amyloid-β', Acta Neuropathologica, vol. 129, pp. 207 - 220, http://dx.doi.org/10.1007/s00401-014-1371-2
2015
Delerue F; White M; Ittner LM, 2014, 'Inducible, tightly regulated and non-leaky neuronal gene expression in mice', Transgenic Research, vol. 23, pp. 225 - 233, http://dx.doi.org/10.1007/s11248-013-9767-7
2014
Chua SW; Kassiou M; Ittner LM, 2014, 'The translocator protein as a drug target in Alzheimer's disease', Expert Review of Neurotherapeutics, vol. 14, pp. 439 - 448, http://dx.doi.org/10.1586/14737175.2014.896201
2014
Gladbach A; Van Eersel J; Bi M; Ke YD; Ittner LM, 2014, 'ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke', Journal of Neural Transmission, vol. 121, pp. 543 - 547, http://dx.doi.org/10.1007/s00702-013-1138-2
2014
Ittner AA; Bertz J; Chan TYB; Van Eersel J; Polly P; Ittner LM, 2014, 'The nucleotide exchange factor SIL1 is required for glucose-stimulated insulin secretion from mouse pancreatic beta cells in vivo', Diabetologia, vol. 57, pp. 1410 - 1419, http://dx.doi.org/10.1007/s00125-014-3230-z
2014
Ittner AA; Gladbach A; Bertz J; Suh LS; Ittner LM, 2014, 'p38 MAP kinase-mediated NMDA receptor-dependent suppression of hippocampal hypersynchronicity in a mouse model of Alzheimer's disease', Acta Neuropathologica Communications, vol. 2, http://dx.doi.org/10.1186/s40478-014-0149-z
2014
Ong WY; Tanaka K; Dawe GS; Ittner LM; Farooqui AA, 2013, 'Slow excitotoxicity in alzheimer's disease', Journal of Alzheimer's Disease, vol. 35, pp. 643 - 668, http://dx.doi.org/10.3233/JAD-121990
2013
Nilsen LH; Rae CD; Ittner LM; Gotz J; Sonnewald U, 2013, 'Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation', Journal of Cerebral Blood Flow and Metabolism, vol. 33, pp. 684 - 691, http://dx.doi.org/10.1038/jcbfm.2012.212
2013
Rosenmann H; Blum D; Kayed R; Ittner LM, 2012, 'Tau protein: Function and pathology', International Journal of Alzheimer's Disease, http://dx.doi.org/10.1155/2012/707482
2012
Ke Y; Dramiga J; Schütz U; Kril JJ; Ittner LM; Schröder HR; Götz JR, 2012, 'Correction: Tau-Mediated Nuclear Depletion and Cytoplasmic Accumulation of SFPQ in Alzheimer's and Pick's Disease', PLoS ONE, vol. 7, http://dx.doi.org/10.1371/annotation/6650167a-7567-4c65-931f-4be7145a39fc
2012
Götz J; Matamales M; Götz NN; Ittner LM; Eckert A, 2012, 'Alzheimer's disease models and functional genomics-How many needles are there in the haystack?', Frontiers in Physiology, vol. 3 AUG, http://dx.doi.org/10.3389/fphys.2012.00320
2012
Scarf AM; Luus C; da Pozzo E; Selleri S; Guarino C; Martini C; Ittner LM; Kassiou M, 2012, 'Evidence for complex binding profiles and species differences at the translocator protein (TSPO) (18 kDa)', Current Molecular Medicine, vol. 12, pp. 488 - 493
2012
Götz J; Ittner A; Ittner LM, 2012, 'Tau-targeted treatment strategies in Alzheimer's disease', British Journal of Pharmacology, vol. 165, pp. 1246 - 1259, http://dx.doi.org/10.1111/j.1476-5381.2011.01713.x
2012
Lu H-K; Zhang Z; Ke Y-H; He J-W; Fu W-Z; Zhang C-Q; Zhang Z-L, 2012, 'High Prevalence of Vitamin D Insufficiency in China: Relationship with the Levels of Parathyroid Hormone and Markers of Bone Turnover', PLOS ONE, vol. 7, http://dx.doi.org/10.1371/journal.pone.0047264
2012
Schonrock N; Matamalesb M; Ittner L; Gotz J, 2012, 'MicroRNA networks surrounding APP and amyloid-beta metabolism - Implications for Alzheimer's disease', Experimental Neurology, vol. 235, pp. 447 - 454, http://dx.doi.org/10.1016/j.expneurol.2011.11.013
2012
Ke Y; Dramiga J; Schütz U; Kril JJ; Ittner LM; Schröder H; Götz J, 2012, 'Tau-mediated nuclear depletion and cytoplasmic accumulation of SFPQ in Alzheimer's and Pick's disease.', PloS one, vol. 7, http://dx.doi.org/10.1371/journal.pone.0035678
2012
Ke YD; Suchowerska AK; Van Der Hoven J; De Silva DM; Wu CW; Van Eersel J; Ittner A; Ittner LM, 2012, 'Lessons from Tau-deficient mice', International Journal of Alzheimer's Disease, http://dx.doi.org/10.1155/2012/873270
2012
van Eersel J; Ke YD; Gladbach A; Bi M; Götz J; Kril JJ; Ittner LM, 2011, 'Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons', PLoS ONE, vol. 6, http://dx.doi.org/10.1371/journal.pone.0022850
2011
Liu X; Dobbie M; Tunningley R; Whittle B; Zhang Y; Ittner LM; Götz J, 2011, 'ENU mutagenesis screen to establish motor phenotypes in wild-type mice and modifiers of a pre-existing motor phenotype in tau mutant mice', Journal of Biomedicine and Biotechnology, vol. 2011, http://dx.doi.org/10.1155/2011/130947
2011
Lim YA; Grimm A; Giese M; Mensah-Nyagan AG; Villafranca JE; Ittner LM; Eckert A; Götz J, 2011, 'Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol', PLoS ONE, vol. 6, http://dx.doi.org/10.1371/journal.pone.0028887
2011
Götz J; Eckert A; Matamales M; Ittner LM; Liu X, 2011, 'Modes of Aβ toxicity in Alzheimer's disease', Cellular and Molecular Life Sciences, vol. 68, pp. 3359 - 3375, http://dx.doi.org/10.1007/s00018-011-0750-2
2011
Gotz J; Schonrock N; Vissel B; Ittner L, 2011, 'Alzheimer's disease selective vulnerability and modelling in transgenic mice', Advances in Alzheimer's Disease, vol. 1, pp. 49 - 58, http://dx.doi.org/10.3233/978-1-60750-733-8-49
2011
Bi M; Ittner A; Ke YD; Götz J; Ittner LM, 2011, 'Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice', PLoS ONE, vol. 6, http://dx.doi.org/10.1371/journal.pone.0026860
2011
Ittner LM; Götz J, 2011, 'Amyloid-β and tau - A toxic pas de deux in Alzheimer's disease', Nature Reviews Neuroscience, vol. 12, pp. 67 - 72, http://dx.doi.org/10.1038/nrn2967
2011
Ittner A; Ke YD; Van Eersel J; Gladbach A; Götz J; Ittner LM, 2011, 'Brief update on different roles of tau in neurodegeneration', IUBMB Life, vol. 63, pp. 495 - 502, http://dx.doi.org/10.1002/iub.467
2011
Krupka N; Strappe P; Götz J; Ittner LM, 2010, 'Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins', Plasmid, vol. 63, pp. 155 - 160, http://dx.doi.org/10.1016/j.plasmid.2010.01.002
2010
Lim YA; Rhein V; Baysang G; Meier F; Poljak A; Raftery MJ; Guilhaus M; Ittner LM; Eckert A; Götz J, 2010, 'Aβ and human amylin share a common toxicity pathway via mitochondrial dysfunction', Proteomics, vol. 10, pp. 1621 - 1633, http://dx.doi.org/10.1002/pmic.200900651
2010
Schonrock N; Yazi DK; Humphreys D; Staufenbiel M; Ittner LM; Preiss T; Gotz J, 2010, 'Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta', PLoS One, vol. 5, pp. e11070, http://dx.doi.org/10.1371/journal.pone.0011070
2010
Ittner LM; Ke YD; Delerue F; Bi M; Gladbach A; van Eersel J; Wolfing H; Chieng BC; Christie MJ; Napier IA; Eckert A; Staufenbiel M; Hardeman E; Gotz J, 2010, 'Dendritic function of Tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models', Cell, vol. 142, pp. 387 - 397, http://dx.doi.org/10.1016/j.cell.2010.06.036
2010
Van Eersel J; Ke YD; Liu X; Delerue F; Kril JJ; Götz J; Ittner LM, 2010, 'Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models', Proceedings of the National Academy of Sciences of the United States of America, vol. 107, pp. 13888 - 13893, http://dx.doi.org/10.1073/pnas.1009038107
2010
Götz J; Lim YA; Ke YD; Eckert A; Ittner LM, 2010, 'Dissecting Toxicity of Tau and β-Amyloid', Neurodegenerative Diseases, vol. 7, pp. 10 - 12, http://dx.doi.org/10.1159/000283475
2010
Götz J; Gladbach A; Pennanen L; van Eersel J; Schild A; David D; Ittner LM, 2010, 'Animal models reveal role for tau phosphorylation in human disease', Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1802, pp. 860 - 871, http://dx.doi.org/10.1016/j.bbadis.2009.09.008
2010
Ke YD; Delerue F; Gladbach A; Götz J; Ittner LM, 2009, 'Experimental diabetes mellitus exacerbates Tau pathology in a transgenic mouse model of Alzheimer's disease', PLoS ONE, vol. 4, http://dx.doi.org/10.1371/journal.pone.0007917
2009
Goetz J; Schonrock N; Vissel B; Ittner L, 2009, 'Alzheimer's Disease Selective Vulnerability and Modeling in Transgenic Mice', Journal of Alzheimer's Disease, vol. 18, pp. 243 - 251, http://dx.doi.org/10.3233/JAD-2009-1143
2009
Scarf AM; Ittner LM; Kassiou M, 2009, 'The translocator protein (18 kDa): Central nervous system disease and drug design', Journal of Medicinal Chemistry, vol. 52, pp. 581 - 592, http://dx.doi.org/10.1021/jm8011678
2009
Ittner LM; Ke YD; Götz J, 2009, 'Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease', Journal of Biological Chemistry, vol. 284, pp. 20909 - 20916, http://dx.doi.org/10.1074/jbc.M109.014472
2009
Rhein V; Song X; Wiesner A; Ittner LM; Baysang G; Meier F; Ozmen L; Bluethmann H; Dröse S; Brandt U; Savaskan E; Czech C; Götz J; Eckert A, 2009, 'Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice', Proceedings of the National Academy of Sciences of the United States of America, vol. 106, pp. 20057 - 20062, http://dx.doi.org/10.1073/pnas.0905529106
2009
Fath T; Ke YD; Gunning P; Gotz J; Ittner LM, 2009, 'Primary support cultures of hippocampal and substantia nigra neurons', Nature Protocols, vol. 4, pp. 78 - 85, http://dx.doi.org/10.1038/nprot.2008.199
2009
Götz J; Ittner LM; Lim YA, 2009, 'Common features between diabetes mellitus and Alzheimer's disease', Cellular and Molecular Life Sciences, vol. 66, pp. 1321 - 1325, http://dx.doi.org/10.1007/s00018-009-9070-1
2009
Van Eersel J; Bi M; Ke Y; Hodges JR; Xuereb J; Gregory GC; Halliday GM; Gotz J; Kril J; Ittner L, 2009, 'Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains', Journal of Neural Transmission, vol. 116, pp. 1243 - 1251, http://dx.doi.org/10.1007/s00702-009-0293-y
2009
Deters N; Ittner LM; Götz J, 2009, 'Substrate-specific reduction of PP2A activity exaggerates tau pathology', Biochemical and Biophysical Research Communications, vol. 379, pp. 400 - 405, http://dx.doi.org/10.1016/j.bbrc.2008.12.140
2009
Götz J; Ittner LM; Schonrock N; Cappai R, 2008, 'An update on the toxicity of Aβ in Alzheimer's disease', Neuropsychiatric Disease and Treatment, vol. 4, pp. 1033 - 1042
2008
Ittner LM; Schwerdtfeger K; Kunz TH; Muff R; Husmann K; Grimm C; Hafezi F; Langh KS; Kurrer MO; Götz J; Born W; Fischer JA, 2008, 'Transgenic mice with ocular overexpression of an adrenomedullin receptor reflect human acute angle-closure glaucoma', Clinical Science, vol. 114, pp. 49 - 58, http://dx.doi.org/10.1042/CS20070163
2008
Lim YA; Ittner LM; Lim YL; Götz J, 2008, 'Human but not rat amylin shares neurotoxic properties with Aβ42 in long-term hippocampal and cortical cultures', FEBS Letters, vol. 582, pp. 2188 - 2194, http://dx.doi.org/10.1016/j.febslet.2008.05.006
2008
Götz J; Ittner LM, 2008, 'Animal models of Alzheimer's disease and frontotemporal dementia', Nature Reviews Neuroscience, vol. 9, pp. 532 - 544, http://dx.doi.org/10.1038/nrn2420
2008
Falk S; Wurdak H; Ittner LM; Ille F; Sumara G; Schmid MT; Draganova K; Lang KS; Paratore C; Leveen P; Suter U; Karlsson S; Born W; Ricci R; Götz M; Sommer L, 2008, 'Brain Area-Specific Effect of TGF-β Signaling on Wnt-Dependent Neural Stem Cell Expansion', Cell Stem Cell, vol. 2, pp. 472 - 483, http://dx.doi.org/10.1016/j.stem.2008.03.006
2008
Götz J; Ittner LM; Fändrich M; Schonrock N, 2008, 'Is tau aggregation toxic or protective: A sensible question in the absence of sensitive methods?', Journal of Alzheimer's Disease, vol. 14, pp. 423 - 429, http://dx.doi.org/10.3233/JAD-2008-14410
2008
Deters N; Ittner LM; Götz J, 2008, 'Divergent phosphorylation pattern of tau in P301L tau transgenic mice', European Journal of Neuroscience, vol. 28, pp. 137 - 147, http://dx.doi.org/10.1111/j.1460-9568.2008.06318.x
2008
Gotz J; David D; Hoerndli F; Ke YD; Schonrock N; Weisner A; Fath T; Bokhari L; Lim Y-A; Deters N; Ittner LM, 2008, 'Functional Genomics Dissects Pathomechanisms in Tauopathies: Mitosis Failure and Unfolded Protein Response', Neurodegenerative Diseases, vol. 5, pp. 179 - 181, http://dx.doi.org/10.1159/000113696
2008
Ittner LM; Ke YD; Fath T; Schonrock N; Gunning P; Gotz J, 2008, 'P2-129: Parkinsonism and memory impairment in tau transgenic mice with axonal transport defects', Alzheimer's & Dementia, vol. 4, pp. T408 - T408, http://dx.doi.org/10.1016/j.jalz.2008.05.1202
2008
Ke YD; Ittner LM; Gunning P; Gotz J; Fath T, 2008, 'P1-142: A new neurotrophic support culture technique for primary neurons', Alzheimer's & Dementia, vol. 4, pp. T248 - T248, http://dx.doi.org/10.1016/j.jalz.2008.05.729
2008
Ittner LM; Fath T; Ke YD; Bi M; van Eersel J; Li KM; Gunning P; Gotz J, 2008, 'Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia', Proceedings of the National Academy of Sciences of the United States of America, vol. 105, pp. 15997 - 16002, http://dx.doi.org/10.1073/pnas.0808084105
2008
Ille F; Atanasoski S; Falk S; Ittner LM; Märki D; Büchmann-Møller S; Wurdak H; Suter U; Taketo MM; Sommer L, 2007, 'Wnt/BMP signal integration regulates the balance between proliferation and differentiation of neuroepithelial cells in the dorsal spinal cord', Developmental Biology, vol. 304, pp. 394 - 408, http://dx.doi.org/10.1016/j.ydbio.2006.12.045
2007
Stanescu D; Iseli HP; Schwerdtfeger K; Ittner LM; Remé CE; Hafezi F, 2007, 'Continuous expression of the homeobox gene Pax6 in the ageing human retina', Eye, vol. 21, pp. 90 - 93, http://dx.doi.org/10.1038/sj.eye.6702166
2007
Götz J; Deters N; Doldissen A; Bokhari L; Ke Y; Wiesner A; Schonrock N; Ittner LM, 2007, 'A decade of tau transgenic animal models and beyond', Brain Pathology, vol. 17, pp. 91 - 103, http://dx.doi.org/10.1111/j.1750-3639.2007.00051.x
2007
Götz J; David DC; Ittner LM, 2007, 'Impact of β-amyloid on the tau pathology in tau transgenic mouse and tissue culture models', Abeta Peptide and Alzheimer's Disease: Celebrating a Century of Research, pp. 198 - 215, http://dx.doi.org/10.1007/978-1-84628-440-3_12
2007
Kunz TH; Mueller-Steiner S; Schwerdtfeger K; Kleinert P; Troxler H; Kelm JM; Ittner LM; Fischer JA; Born W, 2007, 'Interaction of receptor-activity-modifying protein1 with tubulin', Biochimica et Biophysica Acta - General Subjects, vol. 1770, pp. 1145 - 1150, http://dx.doi.org/10.1016/j.bbagen.2007.04.002
2007
Kunz TH; Scott M; Ittner LM; Fischer JA; Born W; Vogel J, 2007, 'Calcitonin gene-related peptide-evoked sustained tachycardia in calcitonin receptor-like receptor transgenic mice is mediated by sympathetic activity', American Journal of Physiology - Heart and Circulatory Physiology, vol. 293, http://dx.doi.org/10.1152/ajpheart.00629.2007
2007
Ittner LM; Götz J, 2007, 'Pronuclear injection for the production of transgenic mice', Nature Protocols, vol. 2, pp. 1206 - 1215, http://dx.doi.org/10.1038/nprot.2007.145
2007
Schild A; Isenmann S; Tanimoto N; Tonagel F; Seeliger MW; Ittner LM; Kretz A; Ogris E; Götz J, 2006, 'Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice', Mechanisms of Development, vol. 123, pp. 362 - 371, http://dx.doi.org/10.1016/j.mod.2006.03.003
2006
Götz J; Ittner LM; Kins S, 2006, 'Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease?', Journal of Neurochemistry, vol. 98, pp. 993 - 1006, http://dx.doi.org/10.1111/j.1471-4159.2006.03955.x
2006
Kelm JM; Djonov V; Hoerstrup SP; Guenter CI; Ittner LM; Greve F; Hierlemann A; Sanchez-Bustamante CD; Perriard JC; Ehler E; Fussenegger M, 2006, 'Tissue-transplant fusion and vascularization of myocardial microtissues and macrotissues implanted into chicken embryos and rats', Tissue Engineering, vol. 12, pp. 2541 - 2553, http://dx.doi.org/10.1089/ten.2006.12.2541
2006
Kelm JM; Djonov V; Ittner LM; Fluri D; Born W; Hoerstrup SP; Fussenegger M, 2006, 'Design of custom-shaped vascularized tissues using microtissue spheroids as minimal building units', Tissue Engineering, vol. 12, pp. 2151 - 2160, http://dx.doi.org/10.1089/ten.2006.12.2151
2006
Wurdak H; Ittner LM; Sommer L, 2006, 'DiGeorge syndrome and pharyngeal apparatus development', BioEssays, vol. 28, pp. 1078 - 1086, http://dx.doi.org/10.1002/bies.20484
2006
Schild A; Schmidt K; Lim YA; Ke Y; Ittner LM; Hemmings BA; Götz J, 2006, 'Altered levels of PP2A regulatory B/PR55 isoforms indicate role in neuronal differentiation', International Journal of Developmental Neuroscience, vol. 24, pp. 437 - 443, http://dx.doi.org/10.1016/j.ijdevneu.2006.08.005
2006
David DJ; Ittner L; Gehrig P; Nergenau D; Shepherd CE; Halliday GM; Gotz J, 2006, 'Beta-amyloid treatment of two complementary P301L tau-expressing Alzheimer's disease models reveals similar deregulated cellular processes', Proteomics, vol. 6, pp. 6566 - 6577, http://dx.doi.org/10.1002/pmic.200600634
2006
Götz J; Ittner LM; Schonrock N, 2006, 'Alzheimer's disease and frontotemporal dementia: Prospects of a tailored therapy?', Medical Journal of Australia, vol. 185, pp. 381 - 384
2006
Tam CW; Husmann K; Clark NC; Clark JE; Lazar Z; Ittner LM; Götz J; Douglas G; Grant AD; Sugden D; Poston L; Poston R; McFadzean I; Marber MS; Fischer JA; Born W; Brain SD, 2006, 'Enhanced vascular responses to adrenomedullin in mice overexpressing receptor-activity-modifying protein 2', Circulation Research, vol. 98, pp. 262 - 270, http://dx.doi.org/10.1161/01.RES.0000200737.63865.58
2006
Kelm JM; Ittner LM; Born W; Djonov V; Fussenegger M, 2006, 'Self-assembly of sensory neurons into ganglia-like microtissues', Journal of Biotechnology, vol. 121, pp. 86 - 101, http://dx.doi.org/10.1016/j.jbiotec.2005.07.009
2006
Schild A; Ittner LM; Götz J, 2006, 'Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice', Biochemical and Biophysical Research Communications, vol. 343, pp. 1171 - 1178, http://dx.doi.org/10.1016/j.bbrc.2006.03.066
2006
Lang KS; Recher M; Junt T; Navarini AA; Harris NL; Freigang S; Odermatt B; Conrad C; Ittner LM; Bauer S; Luther SA; Uematsu S; Akira S; Hengartner H; Zinkernagel RM, 2005, 'Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease', Nature Medicine, vol. 11, pp. 138 - 145, http://dx.doi.org/10.1038/nm1176
2005
Kléber M; Lee HY; Wurdak H; Buchstaller J; Riccomagno MM; Ittner LM; Suter U; Epstein DJ; Sommer L, 2005, 'Neural crest stem cell maintenance by combinatorial Wnt and BMP signaling', Journal of Cell Biology, vol. 169, pp. 309 - 320, http://dx.doi.org/10.1083/jcb.200411095
2005
Ittner LM; Koller D; Muff R; Fischer JA; Born W, 2005, 'The N-terminal extracellular domain 23-60 of the calcitonin receptor-like receptor in chimeras with the parathyroid hormone receptor mediates association with receptor activity-modifying protein 1', Biochemistry, vol. 44, pp. 5749 - 5754, http://dx.doi.org/10.1021/bi048111o
2005
Kelm JM; Sanchez-Bustamante CD; Ehler E; Hoerstrup SP; Djonov V; Ittner L; Fussenegger M, 2005, 'VEGF profiling and angiogenesis in human microtissues', Journal of Biotechnology, vol. 118, pp. 213 - 229, http://dx.doi.org/10.1016/j.jbiotec.2005.03.016
2005
Wurdak H; Ittner LM; Lang KS; Leveen P; Suter U; Fischer JA; Karlsson S; Born W; Sommer L, 2005, 'Inactivation of TGFβ signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome', Genes and Development, vol. 19, pp. 530 - 535, http://dx.doi.org/10.1101/gad.317405
2005
Ittner LM; Wurdak H; Schwerdtfeger K; Kunz T; Ille F; Leveen P; Hjalt TA; Suter U; Karlsson S; Hafezi F; Born W; Sommer L, 2005, 'Compound developmental eye disorders following inactivation of TGFβ signaling in neural-crest stem cells', Journal of Biology, vol. 4, http://dx.doi.org/10.1186/jbiol29
2005
Götz J; Ittner LM; David DC, 2005, 'Role of the protein tau in Alzheimer's disease', Drug Discovery Today: Disease Mechanisms, vol. 2, pp. 395 - 400, http://dx.doi.org/10.1016/j.ddmec.2005.11.008
2005
Lang KS; Recher M; Junt T; Navarini AA; Harris NL; Freigang S; Odermatt B; Conrad C; Ittner LM; Bauer S; Luther SA; Uematsu S; Akira S; Hengartner H; Zinkernagel RM, 2005, 'Erratum: Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease (Nature Medicine (2005) 11 (138-145))', Nature Medicine, vol. 11, pp. 1256, http://dx.doi.org/10.1038/nm1105-1256
2005
Ittner LM; Luessi F; Koller D; Born W; Fischer JA; Muff R, 2004, 'Aspartate69 of the calcitonin-like receptor is required for its functional expression together with receptor-activity-modifying proteins 1 and -2', Biochemical and Biophysical Research Communications, vol. 319, pp. 1203 - 1209, http://dx.doi.org/10.1016/j.bbrc.2004.05.103
2004
Koller D; Ittner LM; Muff R; Husmann K; Fischer JA; Born W, 2004, 'Selective Inactivation of Adrenomedullin over Calcitonin Gene-related Peptide Receptor Function by the Deletion of Amino Acids 14-20 of the Mouse Calcitonin-like Receptor', Journal of Biological Chemistry, vol. 279, pp. 20387 - 20391, http://dx.doi.org/10.1074/jbc.M313058200
2004
Ittner L; Born W; Rau B; Steinbach G; Fischer JA, 2002, 'Circulating procalcitonin and cleavage products in septicaemia compared with medullary thyroid carcinoma', European Journal of Endocrinology, vol. 147, pp. 727 - 731, http://dx.doi.org/10.1530/eje.0.1470727
2002