Krista Siefried

Clinical Research Lead
Senior Research Associate

Clinical Research Lead and Deputy Director of the National Centre for Clinical Research on Emerging Drugs (NCCRED). Lecturer at the UNSW National Drug and Alcohol Research Centre (NDARC), and Senior Research Associate at St Vincent's Hospital Sydney Centre for Applied Medical Research (SVHS AMR).

Dr Siefried is an emerging leader in clinical research and clinical trials in vulnerable populations. In her role as Clinical Research Lead and Deputy Director at NCCRED her extensive HIV, Infectious Diseases, Drug and Alcohol, and Public Health experience enable her to direct a program of clinical research; facilitate the establishment of a national clinical research network; and oversee the NCCRED clinical research capacity building grants, seed funding grants, and clinical research fellowships. 

Dr Siefried has extensive experience in clinical research, healthcare, and clinical project management. Prior senior leadership roles include: Senior Clinical Project Manager (SVHS AMR); Clinical Research Manager (SVHS AMR Clinical Research Program); and Nurse Unit Manager (Immunology and Infectious Diseases). Prior clinical experience includes Research Nurse and Clinical Trials Coordinator; Registered Nurse / Clinical Nurse Specialist; Heart/Lung Transplant Coordinator; ICU and CCU Registered Nurse (in Australia and Canada). 

Broad clinical research interests include comorbidities and treatment outcomes in people living with HIV, and pharmacotherapy for people with methamphetamine dependence.

Journal articles
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Siefried KJ; Acheson LS; Lintzeris N; Ezard N, 2020, 'Pharmacological treatment of methamphetamine/amphetamine dependence: a systematic review', CNS Drugs, http://dx.doi.org/10.1007/s40263-020-00711-x
2020
Siefried KJ; Kerr S; Richardson R; Mao L; Rule J; McAllister J; De Wit J; Carr A, 2019, 'Socioeconomic and psychosocial factors are associated with poor treatment outcomes in Australian adults living with HIV: A case-control study', Sexual Health, vol. 16, pp. 548 - 553, http://dx.doi.org/10.1071/SH18138
2019
Siefried KJ; Mao L; Cysique LA; Rule J; Giles ML; Smith DE; McMahon J; Read TR; Ooi C; Tee BK; Bloch M; De Wit J; Carr A, 2018, 'Concomitant medication polypharmacy, interactions and imperfect adherence are common in Australian adults on suppressive antiretroviral therapy', AIDS, vol. 32, pp. 35 - 48, http://dx.doi.org/10.1097/QAD.0000000000001685
2018
Siefried KJ; Mao L; Kerr S; Cysique LA; Gates TM; McAllister J; Maynard A; De Wit J; Carr A, 2017, 'Socioeconomic factors explain suboptimal adherence to antiretroviral therapy among HIV-infected Australian adults with viral suppression', PLoS ONE, vol. 12, http://dx.doi.org/10.1371/journal.pone.0174613
2017
Gates TM; Cysique LA; Siefried KJ; Chaganti J; Moffat KJ; Brew BJ, 2016, 'Maraviroc-intensified combined antiretroviral therapy improves cognition in virally suppressed HIV-associated neurocognitive disorder', AIDS, vol. 30, pp. 591 - 600, http://dx.doi.org/10.1097/QAD.0000000000000951
2016
Lu GM; Brew BJ; Siefried KJ; Draper B; Cysique LA, 2014, 'Is the HIV dementia scale a reliable tool for assessing HIV-relatedneurocognitive decline?', Journal of AIDS and Clinical Research, vol. 5, http://dx.doi.org/10.4172/2155-6113.1000269
2014
Conference Papers
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Siefried KJ; Nguyen QA; Ezard N; Christmass M; Ali R, 2019, 'A rapid clinical research priority setting study for substance use disorder due to methamphetamine and emerging drugs of concern in Australia', in Drug and Alcohol Review, Wiley, Hobart, Australia, presented at Australasian Professional Society on Alcohol and other Drugs (APSAD) Scientific Conference, Hobart, Australia, 10 November 2019 - 13 November 2019, http://dx.doi.org/10.1111/dar.12991
2019
Sandra S; Demerikol A; Branezac M; Ezard N; Siefried KJ; Acheson LS; Bascombe F; Tremonti C; Haber P; Lintzeris N, 2019, 'Are we detoxing the right people, in the right setting and in the right way? A rapid review of the literature on withdrawal management', in Drug and Alcohol Review, Wiley, Hobart, Australia, presented at Australasian Professional Society on Alcohol and other Drugs (APSAD) Scientific Conference, Hobart, Australia, 10 November 2019 - 13 November 2019, http://dx.doi.org/10.1111/dar.12991
2019
Acheson LS; Murray E; Clifford B; Siefried KJ; Matthews GV; Ezard N, 2019, 'Optimising care for people who inject drugs: A retrospective medical record review of staphylococcus aureus bactaraemia treatment', in Drug and Alcohol Review, Wiley, Hobart, Australia, presented at Australasian Professional Society on Alcohol and other Drugs (APSAD) Scientific Conference, Hobart, Australia, 10 November 2019 - 13 November 2019, http://dx.doi.org/10.1111/dar.12991
2019
Nguyen QA; Middleton P; Herman D; Li K; Grundy E; Li E; Siefried KJ; Malone V; Kay-Lambkin F; Ezard N, 2019, 'What's in an app? Incorporating an automated consent procedure to recruit those who use methamphetamine to a harm reduction and early intervention smartphone-based application clinical trial', in Drug and Alcohol Review, Wiley, Hobart, Australia, presented at Australasian Professional Society on Alcohol and other Drugs (APSAD) Scientific Conference, Hobart, Australia, 10 November 2019 - 13 November 2019, http://dx.doi.org/10.1111/dar.12991
2019
Siefried KJ; Mao L; Richardson R; Kerr S; Rule J; McAllister J; de Wit J; Carr A, 2017, 'Socioeconomic and psychosocial factors are associated with suboptimal outcomes in HIV-infected adults: a case-control analysis', in Antiviral Therapy, International Medical Press, Milan, Italy, presented at The 19th International Workshop on Co-morbidities and Adverse Drug Reaction in HIV, Milan, Italy, 23 October 2017 - 25 October 2017
2017
Siefried KJ; Mao L; Cysique LA; Rule J; Giles ML; Smith DE; McMahon J; Read TR; Ooi C; Tee BK; Bloch M; de Wit J; Carr A, 2017, 'Polypharmacy of concomitant medications in HIV-infected Australian adults is common, and associated with adverse effects', in Antiviral Therapy, International Medical Press, Milan, Italy, presented at The 19th International Workshop on Co-morbidities and Adverse Drug Reaction in HIV, Milan, Italy, 23 October 2017 - 25 October 2017
2017
Siefried KJ; Mao L; Riches R; Kerr S; Rule J; McAllister J; de Wit J; Carr A, 2017, 'Failure of antiretroviral therapy (ART) in Australian adults is mainly due to ART toxicity', in Antiviral Therapy, International Medical Press, Milan, Italy, presented at The 19th International Workshop on Co-morbidities and Adverse Drug Reaction in HIV, Milan, Italy, 23 October 2017 - 25 October 2017
2017
Siefried KJ; Mao L; Kerr S; Gates T; Maynard A; Cysique LA; McAllister J; de Wit J; Carr A, 2016, 'Concomitant medication use in ART-experienced Australian adults: data from the PAART study', in Antiviral Therapy, International Medical Press, New York City, USA, presented at The 18th International Workshop on Co-morbidities and Adverse Drug Reactions in HIV, New York City, USA, 12 September 2016 - 13 September 2016
2016
Lu G; Brew B; Siefried K; Draper B; Cysique L, 2013, 'Moderate neurocognitive decline can be detected over a four-month period using the HIV-dementia scale', in JOURNAL OF NEUROVIROLOGY, SPRINGER, Washington, DC, pp. S51 - S51, presented at 12th International Symposium on NeuroVirology, Washington, DC, 29 October 2013 - 02 November 2013, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000325777200107&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2013
Conference Presentations
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Siefried K; Nguyen Q; Ezard N, 2019, 'An Australian clinical research priority setting study for substance use disorder due to methamphetamine and emerging drugs of concern', presented at Lisbon Addictions 2019: The Third European Conference on Addictive Behaviours and Dependencies, Lisbon, Portugal, 23 October 2019 - 25 October 2019
2019
Ezard N; Acheson LS; Siefried KJ; Leicester OM; Rodgers C; Malone V; Clifford B; Bruno R, 2019, 'Substance use sex index (SUSI): A new behaviour change assessment tool', presented at Lisbon Addictions 2019: The Third European Conference on Addictive Behaviours and Dependencies, Lisbon, Portugal, 23 October 2019 - 25 October 2019
2019
Siefried KJ; Mao L; Rule J; de Wit J; Carr A, 2018, 'Hospitalisations over a year follow-up in a cohort of adults living with HIV with sustained viral suppression in Australia', presented at The Australasian HIV&AIDS Conference, Sydney, Australia, 24 September 2018 - 26 September 2018
2018
Siefried KJ; Mao L; Riches S; Kerr S; Rule J; McAllister J; de Wit J; Carr A, 2017, 'Failure of antiretroviral therapy (ART) in Australian adults is mainly due to ART toxicity', presented at The Australasian HIV&AIDS Conference, Canberra, Australia, 06 November 2017 - 08 November 2017
2017
Siefried KJ; Mao L; Cysique LA; Rule J; Giles ML; Smith DE; McMahon J; Read TR; Ooi C; Tee BK; Bloch M; de wit J; Carr A, 2017, 'Polypharmacy of concomitant medications in HIV-infected Australian adults is common, and associated with adverse effects', presented at The Australasian HIV&AIDS Conference, Canberra Australia, 06 November 2017 - 08 November 2017
2017
Mao L; Siefried KJ; Carr A; de Wit J, 2016, 'Perceptions of TasP among HIV-positive gay men with sustained viral suppression', presented at 2016 Australasian HIV & AIDS Conference, Adelaide, 16 November 2016 - 18 November 2016
2016
Siefried KJ; Mao L; Kerr S; Gates T; Maynard A; Cysique LA; McAllister J; de Wit J; Carr A, 2016, 'Concomitant medication use in ART-experienced adults: data from the PAART study', presented at The Australasian HIV&AIDS Conference, Adelaide, Australia, 16 November 2016 - 18 November 2016
2016
Siefried KJ; Mao L; Kerr S; Gates T; Cysique LA; de Wit J; Carr A, 2015, 'Parameters associated with adherence to antiretroviral therapy in HIV-infected Australian adults: the PAART study', presented at The Australasian HIV&AIDS Conference, Brisbane, Australia, 16 September 2015 - 18 September 2015
2015
Conference Posters
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Carr M; Martin SJ; Foster R; Finlayson R; Rule J; Smith DE; de Wit J; Carr A; Siefried KJ, 2019, 'STI incidence and risk factors in HIV-infected adults on antiretrovrial therapy (ART) in the PAART study', Perth, Australia, presented at Joint Australasian Sexual Health and HIV&AIDS Conference, Perth, Australia, 16 September 2019 - 19 September 2019
2019
Ezard N; Siefried KJ; Peacock A, 2019, 'Developing a national prompt response network for Australia', Amsterdam, The Netherlands, presented at The 11th International Conference on Nightlife, Substance Use and Related Health Issues, Amsterdam, The Netherlands, 15 May 2019 - 17 May 2019
2019
Siefried KJ; Peacock A; Ezard N, 2019, 'Towards a prompt response network for Australia: coordinated and rapid communication of information about events of concerns related to emerging substances', Maastricht, The Netherlands, presented at Sixth International Conference on Novel Psychoactive Substances, Maastricht, The Netherlands, 08 April 2019 - 09 April 2019
2019
Siefried KJ; Mao L; Riches S; Kerr S; Rule J; de Wit J; Carr A, 2018, 'Failure of antiretroviral therapy (ART) in adults in Australia is mainly due to ART toxicity (an updated report with predictors of ART failure)', Sydney, Australia, presented at The Australasian HIV&AIDS Conference, Sydney, Australia, 24 September 2018 - 26 September 2018
2018
Siefried KJ; Mao L; Riches S; Kerr S; Rule J; McAllister J; de Wit J; Carr A, 2018, 'Failure of antiretroviral therapy (ART) in adults in Australia is mainly due to ART toxicity (updated report with predictors of ART failure)', Amsterdam, the Netherlands, presented at 22nd International AIDS Conference, Amsterdam, the Netherlands, 23 July 2018 - 27 July 2018
2018
Siefried KJ; Mao L; Rule J; de Wit J; Carr A, 2018, 'Hospitalisations over a year follow-up in a cohort of adults living with HIV with sustained viral suppression in Australia', Amsterdam, the Netherlands, presented at 22nd International AIDS Conference, Amsterdam, the Netherlands, 23 July 2018 - 27 July 2018
2018
Siefried KJ; Mao L; Richardson R; Kerr S; Rule J; McAllister J; Carr A, 2017, 'Socioeconomic and psychosocial factors are associated with suboptimal outcomes in HIV-infected adults: a case-control analysis', Canberra, Australia, presented at The Australasian HIV&AIDS Conference, Canberra, Australia, 06 November 2017 - 08 November 2017
2017
Siefried KJ; Mao L; Richardson R; Kerr S; Rule J; McAllister J; de Wit J; Carr A, 2017, 'Socioeconomic and psychosocial factors are associated with suboptimal outcomes in HIV-infected adults: a case-control analysis', Milan, Italy, presented at The 16th European AIDS Conference, Milan, Italy, 25 October 2017 - 27 October 2017
2017
Siefried KJ; Mao L; Riches S; Kerr S; Rule J; McAllister J; de Wit J; Carr A, 2017, 'Failure of antiretroviral therapy (ART) in Australian adults is mainly due to ART toxicity', Milan, Italy, presented at The 16th European AIDS Conference, Milan, Italy, 25 October 2017 - 27 October 2017
2017
Siefried KJ; Mao L; Cysique LA; Rule J; Giles ML; Smith DE; McMahon J; Read TR; Ooi C; Tee BK; Bloch M; de Wit J; Carr A, 2017, 'Polypharmacy of concomitant medications in HIV-infected Australian adults is common, and associated with adverse effects', Milan, Italy, presented at The 16th European AIDS Conference, Milan, Italy, 25 October 2017 - 27 October 2017
2017
Gates T; Cysique LA; Chaganti J; Siefried KJ; Brew BJ, 2015, 'Maraviroc-enhanced CART improves cognition in virally suppressed HAND: a pilot study', Seattle, USA, presented at The 22nd Conference on Retroviruses and Opportunistic Infections (CROI), Seattle, USA, 23 February 2015 - 26 February 2015
2015
Siefried KJ; McAllister J; McNulty A; Read TR; Pearce A; Richardson R; Carr A, 2014, 'Safety and tolerability of, and adherence to, co-formulated emtricitabine-rilpivirine-tenofovir used as HIV non-occupational post-exposure prophylaxis in men who have sex with men', Sydney, Australia, presented at The St Vincent’s and Mater Health Research Symposium, Sydney, Australia, 11 September 2014 - 11 September 2014
2014
Siefried KJ; Mao L; McAllister J; Richardson R; Watson J; de Wit J; Carr A, 2013, 'Predictors of adherence to antiretroviral therapy in HIV-infected adults (the PAART pilot study)', Darwin, Australia, presented at The Australasian HIV&AIDS Conference, Darwin, Australia, 21 October 2013 - 23 October 2013
2013
Lu G; Siefried KJ; Draper B; Brew BJ; Cysique LA, 2013, 'Moderate neurocognitive decline can be detected over a four-month period using the HIV-dementia scale (HDS)', Atlanta, USA, presented at The 20th Conference on Retroviruses and Opportunistic Infections (CROI), Atlanta, USA, 03 March 2013 - 06 March 2013
2013
Ezard N; Dunlop AJ; Clifford B; Bruno R; Siefried KJ; Carr A; Lintzeris N, 'Safety of oral lisdexamfetamine in adults with methamphetamine dependence: a dose-escalating phase-2 study', San Antonio, Texas, USA, presented at The College on Problems of Drug Dependence 81st Annual Scientific Meeting, San Antonio, Texas, USA, 15 June 2019 - 19 July 2019
Reports
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Lintzeris N; Sunjic S; Demirkol A; Branezac M; Ezard N; Siefried K; Acheson LS; Bascombe F; Tremonti C; Haber P, 2019, Management of withdrawal from alcohol and other drugs: an evidence check rapid review brokered by the Sax Institute for the NSW Ministry of Health, Sax Institute
2019
Conference Abstracts
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Black E; Deacon RM; Mills L; Dunlop A; Ezard N; Bruno R; Shakeshaft A; Farrell M; Holmes J; Cretikos MA; Montebello M; Reid D; Childs S; Siefried KJ; Mammen K; Lintzeris N, 2019, 'Characteristics and treatment outcomes of the drug treatment population in New South Wales: Focus on amphetamine type stimulants', in Drug and Alcohol Review, Wiley, Hobart, Australia, Vol. 38, presented at Australasian Professional Society on Alcohol and other Drugs (APSAD) Scientific Conference, Hobart, Australia, 10 November 2019 - 13 November 2019, http://dx.doi.org/10.1111/dar.12991
2019
Theses / Dissertations
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Siefried KJ, 2018, Antiretroviral therapy and treatment cascade outcomes in a cohort of adults living with HIV in Australia
2018

NHMRC: $2,928,298

Other Public and Industry: $1,821,824

 

Current - UNSW Medicine Hons Project

Oliver Harris (2021)

Current - Notre Dame Medicine Year 2 Research Project

Rhiannon Lindsey - A retrospective audit of gamma-hydroxybuterate (GHB) withdrawal in an inner-city Sydney hospital (Co-supervising with Jonathan Brett) (2020)

Completed - UNSW Medicine Year 4 Research Project

Amy Healey - Drug use at music festivals (Co-supervised with Jonathan Brett) (2020)

Angus Tolhurst-McKiernan - Methamphetamine use and its associations with insomnia and psychosis (Co-supervised with Nadine Ezard and Jonathan Brett) (2019) 

Clinical

Nursing preceptorships; Clinical Psychology Students (research supervision and clinical supervision); Nursing student supervision (clinical)