John Pimanda

Professor

We are a molecular and cell biology laboratory with a translational research focus. We study healthy blood stem cells and leukaemic cells. Our investigations are at genome-scale and in single cells. We use this knowledge to improve our biological understanding and management of blood stem disorders such as myelodysplasia and acute myeloid leukaemia. 

Our research interest lies in identifying critical components of the haematopoietic transcriptional network and how it governs stemness. How this network is perturbed in mutant blood stem cells and its impact on clonal dominance and maintenance of leukaemia is a focus. The role of stromal cells in the development of blood stem cells and maintenance of leukaemic cells is also an area of research interest. 

Journal articles
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Lee Q; Padula MP; Pinello N; Williams SH; O’Rourke MB; Fumagalli MJ; Orkin JD; Song R; Shaban B; Brenner O; Pimanda JE; Weninger W; de Souza WM; Melin AD; Wong JJL; Crim MJ; Monette S; Roediger B; Jolly CJ, 2020, 'Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys', PLoS Pathogens, vol. 16, pp. e1008262, http://dx.doi.org/10.1371/journal.ppat.1008262
2020
Khanna A; Thoms JAI; Stringer BW; Chung SA; Ensbey KS; Jue TR; Jahan Z; Subramanian S; Anande G; Shen H; Unnikrishnan A; McDonald KL; Day BW; Pimanda JE, 2020, 'Constitutive CHK1 expression drives a pSTAT3-CIP2A circuit that promotes glioblastoma cell survival and growth.', Mol Cancer Res, http://dx.doi.org/10.1158/1541-7786.MCR-19-0934
2020
Anande G; Deshpande NP; Mareschal S; Batcha AMN; Hampton HR; Herold T; Lehmann S; Wilkins MR; Wong JWH; Unnikrishnan A; Pimanda JE, 2020, 'RNA splicing alterations induce a cellular stress response associated with poor prognosis in Acute Myeloid Leukemia.', Clin Cancer Res, http://dx.doi.org/10.1158/1078-0432.CCR-20-0184
2020
Richards LA; Kumari A; Knezevic K; Thoms JA; von Jonquieres G; Napier CE; Ali Z; O'Brien R; Marks-Bluth J; Maritz MF; Pickett HA; Morris J; Pimanda JE; MacKenzie KL, 2019, 'DKC1 is a transcriptional target of GATA1 and drives upregulation of telomerase activity in normal human erythroblasts.', Haematologica, http://dx.doi.org/10.3324/haematol.2018.215699
2019
Chiu SK; Orive SL; Moon MJ; Saw J; Ellis S; Kile BT; Huang Y; Chacon D; Pimanda JE; Beck D; Hamilton JR; Tremblay CS; Curtis DJ, 2019, 'Shared roles for Scl and Lyl1 in murine platelet production and function', Blood, vol. 134, pp. 826 - 835, http://dx.doi.org/10.1182/blood.2019896175
2019
Poulos RC; Perera D; Packham D; Shah A; Janitz C; Pimanda JE; Hawkins N; Ward RL; Hesson LB; Wong JWH, 2019, 'Scarcity of Recurrent Regulatory Driver Mutations in Colorectal Cancer Revealed by Targeted Deep Sequencing', JNCI CANCER SPECTRUM, vol. 3, http://dx.doi.org/10.1093/jncics/pkz012
2019
Krivtsov AV; Evans K; Gadrey JY; Eschle BK; Hatton C; Uckelmann HJ; Ross KN; Perner F; Olsen SN; Pritchard T; McDermott L; Jones CD; Jing D; Braytee A; Chacon D; Earley E; McKeever BM; Claremon D; Gifford AJ; Lee HJ; Teicher BA; Pimanda JE; Beck D; Perry JA; Smith MA; McGeehan GM; Lock RB; Armstrong SA, 2019, 'A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia', Cancer Cell, vol. 36, pp. 660 - 673.e11, http://dx.doi.org/10.1016/j.ccell.2019.11.001
2019
Thoms JAI; Beck D; Pimanda JE, 2019, 'Transcriptional networks in acute myeloid leukemia', Genes Chromosomes and Cancer, vol. 58, pp. 859 - 874, http://dx.doi.org/10.1002/gcc.22794
2019
Kumar P; Beck D; Galeev R; Thoms JAI; Talkhoncheh MS; de Jong I; Unnikrishnan A; Baudet A; Subramaniam A; Pimanda JE; Larsson J, 2019, 'HMGA2 promotes long-term engraftment and myeloerythroid differentiation of human hematopoietic stem and progenitor cells', Blood Advances, vol. 3, pp. 681 - 691, http://dx.doi.org/10.1182/bloodadvances.2018023986
2019
Ali A; Penneroux J; Dal Bello R; Massé A; Quentin S; Unnikrishnan A; Hernandez L; Raffoux E; Ben Abdelali R; Renneville A; Preudhomme C; Pimanda J; Dombret H; Soulier J; Fenaux P; Clappier E; Adès L; Puissant A; Itzykson R, 2018, 'Granulomonocytic progenitors are key target cells of azacytidine in higher risk myelodysplastic syndromes and acute myeloid leukemia', Leukemia, vol. 32, pp. 1856 - 1860, http://dx.doi.org/10.1038/s41375-018-0076-2
2018
Chiu SK; Saw J; Huang Y; Sonderegger SE; Wong NC; Powell DR; Beck D; Pimanda JE; Tremblay CS; Curtis DJ, 2018, 'A novel role for Lyl1 in primitive erythropoiesis', Development (Cambridge), vol. 145, http://dx.doi.org/10.1242/dev.162990
2018
Unnikrishnan A; Vo ANQ; Pickford R; Raftery MJ; Nunez AC; Verma A; Hesson LB; Pimanda JE, 2018, 'AZA-MS: A novel multiparameter mass spectrometry method to determine the intracellular dynamics of azacitidine therapy in vivo', Leukemia, vol. 32, pp. 900 - 910, http://dx.doi.org/10.1038/leu.2017.340
2018
Jing D; Huang Y; Liu X; Sia KCS; Zhang JC; Tai X; Wang M; Toscan CE; McCalmont H; Evans K; Mayoh C; Poulos RC; Span M; Mi J; Zhang C; Wong JWH; Beck D; Pimanda JE; Lock RB, 2018, 'Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia', Cancer Cell, vol. 34, pp. 906 - 921.e8, http://dx.doi.org/10.1016/j.ccell.2018.11.002
2018
Liu Q; Thoms JAI; Nunez AC; Huang Y; Knezevic K; Packham D; Poulos RC; Williams R; Beck D; Hawkins NJ; Ward RL; Wong JWH; Hesson LB; Sloane MA; Pimanda JE, 2018, 'Disruption of a 35 KB enhancer impairs CTCF binding and MLH1 expression in colorectal cells', Clinical Cancer Research, vol. 24, pp. 4602 - 4611, http://dx.doi.org/10.1158/1078-0432.CCR-17-3678
2018
Smeets MF; Tan SY; Xu JJ; Anande G; Unnikrishnan A; Chalk AM; Taylor SR; Pimanda JE; Wall M; Purton LE; Walkley CR, 2018, 'Srsf2P95H initiates myeloid bias and myelodysplastic/ myeloproliferative syndrome from hemopoietic stem cells', Blood, vol. 132, pp. 608 - 621, http://dx.doi.org/10.1182/blood-2018-04-845602
2018
Jacquelin S; Straube J; Cooper L; Vu T; Song A; Bywater M; Baxter E; Heidecker M; Wackrow B; Porter A; Ling V; Green J; Austin R; Kazakoff S; Waddell N; Hesson LB; Pimanda JE; Stegelmann F; Bullinger L; Döhner K; Rampal RK; Heckl D; Hill GR; Lane SW, 2018, 'Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation', Blood, vol. 132, pp. 2707 - 2721, http://dx.doi.org/10.1182/blood-2018-04-846220
2018
Beck D; Thoms JAI; Palu C; Herold T; Shah A; Olivier J; Boelen L; Huang Y; Chacon D; Brown A; Babic M; Hahn C; Perugini M; Zhou X; Huntly BJ; Schwarzer A; Klusmann JH; Berdel WE; Wörmann B; Büchner T; Hiddemann W; Bohlander SK; To LB; Scott HS; Lewis ID; D'Andrea RJ; Wong JWH; Pimanda JE, 2018, 'A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients', Leukemia, vol. 32, pp. 263 - 272, http://dx.doi.org/10.1038/leu.2017.210
2018
Unnikrishnan A; Papaemmanuil E; Beck D; Deshpande NP; Verma A; Kumari A; Woll PS; Richards LA; Knezevic K; Chandrakanthan V; Thoms JAI; Tursky ML; Huang Y; Ali Z; Olivier J; Galbraith S; Kulasekararaj AG; Tobiasson M; Karimi M; Pellagatti A; Wilson SR; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen SEW; Mufti GJ; Hellstrom-Lindberg E; Wilkins MR; MacKenzie KL; Wong JWH; Campbell PJ; Pimanda JE, 2017, 'Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes', Cell Reports, vol. 20, pp. 572 - 585, http://dx.doi.org/10.1016/j.celrep.2017.06.067
2017
Liu K; Beck D; Thoms JAI; Liu L; Zhao W; Pimanda JE; Zhou X, 2017, 'Annotating function to differentially expressed LincRNAs in myelodysplastic syndrome using a network-based method', Bioinformatics, vol. 33, pp. 2622 - 2630, http://dx.doi.org/10.1093/bioinformatics/btx280
2017
Schwarzer A; Emmrich S; Schmidt F; Beck D; Ng M; Reimer C; Adams FF; Grasedieck S; Witte D; Käbler S; Wong JWH; Shah A; Huang Y; Jammal R; Maroz A; Jongen-Lavrencic M; Schambach A; Kuchenbauer F; Pimanda JE; Reinhardt D; Heckl D; Klusmann JH, 2017, 'The non-coding RNA landscape of human hematopoiesis and leukemia', Nature Communications, vol. 8, http://dx.doi.org/10.1038/s41467-017-00212-4
2017
Avellino R; Havermans M; Erpelinck C; Sanders MA; Hoogenboezem R; Van De Werken HJG; Rombouts E; Van Lom K; Van Strien PMH; Gebhard C; Rehli M; Pimanda J; Beck D; Erkeland S; Kuiken T; De Looper H; Gröschel S; Touw I; Bindels E; Delwel R, 2016, 'An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation', Blood, vol. 127, pp. 2991 - 3003, http://dx.doi.org/10.1182/blood-2016-01-695759
2016
Perera D; Poulos RC; Shah A; Beck D; Pimanda JE; Wong JWH, 2016, 'Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes', Nature, vol. 532, pp. 259 - 263, http://dx.doi.org/10.1038/nature17437
2016
Shields BJ; Jackson JT; Metcalf D; Shi W; Huang Q; Garnham AL; Glaser SP; Beck D; Pimanda JE; Bogue CW; Smyth GK; Alexander WS; McCormack MP, 2016, 'Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a', Genes and Development, vol. 30, pp. 78 - 91, http://dx.doi.org/10.1101/gad.268425.115
2016
Hesson LB; Ng B; Zarzour P; Srivastava S; Kwok CT; Packham D; Nunez AC; Beck D; Ryan R; Dower A; Ford CE; Pimanda JE; Sloane MA; Hawkins NJ; Bourke MJ; Wong JWH; Ward RL, 2016, 'Integrated genetic, epigenetic, and transcriptional profiling identifies molecular pathways in the development of laterally spreading tumors', Molecular Cancer Research, vol. 14, pp. 1217 - 1228, http://dx.doi.org/10.1158/1541-7786.MCR-16-0175
2016
Botezatu L; Michel LC; Makishima H; Schroeder T; Germing U; Haas R; Van der Reijden B; Marneth AE; Bergevoet SM; Jansen JH; Przychodzen B; Wlodarski M; Niemeyer C; Platzbecker U; Ehninger G; Unnikrishnan A; Beck D; Pimanda J; Hellström-Lindberg E; Malcovati L; Boultwood J; Pellagatti A; Papaemmanuil E; Le Coutre P; Kaeda J; Opalka B; Möröy T; Dührsen U; Maciejewski J; Khandanpour C, 2016, 'GFI136N as a therapeutic and prognostic marker for myelodysplastic syndrome', Experimental Hematology, vol. 44, pp. 590 - 595.e1, http://dx.doi.org/10.1016/j.exphem.2016.04.001
2016
Richmond J; Robbins A; Evans K; Beck D; Kurmasheva RT; Billups CA; Carol H; Heatley S; Sutton R; Marshall GM; White D; Pimanda J; Houghton PJ; Smith MA; Lock RB, 2016, 'Acute sensitivity of Ph-like acute lymphoblastic leukemia to the SMAC-mimetic birinapant', Cancer Research, vol. 76, pp. 4579 - 4591, http://dx.doi.org/10.1158/0008-5472.CAN-16-0523
2016
Nasrallah R; Fast EM; Solaimani P; Knezevic K; Eliades A; Patel R; Thambyrajah R; Unnikrishnan A; Thoms J; Beck D; Vink CS; Smith A; Wong J; Shepherd M; Kent D; Roychoudhuri R; Paul F; Klippert J; Hammes A; Willnow T; Göttgens B; Dzierzak E; Zon LI; Lacaud G; Kouskoff V; Pimanda JE, 2016, 'Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes', Blood, vol. 128, pp. 1928 - 1939, http://dx.doi.org/10.1182/blood-2016-02-697870
2016
Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A; Villanueva JE; Nunez AC; Knezevic K; Palu C; Nasrallah R; Carnell M; Macmillan A; Whan R; Yu Y; Hardy P; Grey ST; Gladbach A; Delerue F; Ittner L; Mobbs R; Walkley CR; Purton LE; Ward RL; Wong JWH; Hesson LB; Walsh W; Pimanda JE, 2016, 'Pdgf-ab and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113
2016
Khanna A; Pimanda JE, 2016, 'Clinical significance of cancerous inhibitor of protein phosphatase 2A in human cancers', International Journal of Cancer, vol. 138, pp. 525 - 532, http://dx.doi.org/10.1002/ijc.29431
2016
Unnikrishnan A; Guan YF; Huang Y; Beck D; Thoms JAI; Peirs S; Knezevic K; Ma S; De Walle IV; De Jong IDE; Ali Z; Zhong L; Raftery MJ; Taghon T; Larsson J; MacKenzie KL; Van Vlierberghe P; Wong JWH; Pimanda JE, 2016, 'A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network', Nucleic Acids Research, vol. 44, pp. 10644 - 10661, http://dx.doi.org/10.1093/nar/gkw804
2016
Huang Y; Thoms JAI; Tursky ML; Knezevic K; Beck D; Chandrakanthan V; Suryani S; Olivier J; Boulton A; Glaros EN; Thomas SR; Lock RB; MacKenzie KL; Bushweller JH; Wong JWH; Pimanda JE, 2016, 'MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation', Leukemia, vol. 30, pp. 1552 - 1561, http://dx.doi.org/10.1038/leu.2016.55
2016
Poulos RC; Thoms JAI; Guan YF; Unnikrishnan A; Pimanda JE; Wong JWH, 2016, 'Functional Mutations Form at CTCF-Cohesin Binding Sites in Melanoma Due to Uneven Nucleotide Excision Repair across the Motif', Cell Reports, vol. 17, pp. 2865 - 2872, http://dx.doi.org/10.1016/j.celrep.2016.11.055
2016
Thoms JAI; Knezevic K; Liu JJ; Glaros EN; Thai T; Qiao Q; Campbell H; Packham D; Huang Y; Papathanasiou P; Tunningley R; Whittle B; Yeung AWS; Chandrakanthan V; Hesson L; Chen V; Wong JWH; Purton LE; Ward RL; Thomas SR; Pimanda JE, 2016, 'Arrested hematopoiesis and vascular relaxation defects in mice with a mutation in Dhfr', Molecular and Cellular Biology, vol. 36, pp. 1222 - 1236, http://dx.doi.org/10.1128/MCB.01035-15
2016
Kartalaei PS; Yamada-Inagawa T; Vink CS; de Pater E; van der Linden R; Marks-Bluth J; van der Sloot A; van den Hout M; Yokomizo T; Lucila van Schaick-Solernó M; Delwel R; Pimanda JE; van IJcken WFJ; Dzierzak E, 2015, 'Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation', Journal of Experimental Medicine, vol. 212, pp. 93 - 106, http://dx.doi.org/10.1084/jem.20140767
2015
Khanna A; Rane JK; Kivinummi KK; Urbanucci A; Helenius MA; Tolonen TT; Saramäki OR; Latonen L; Manni V; Pimanda JE; Maitland NJ; Westermarck J; Visakorpi T, 2015, 'CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations', Oncotarget, vol. 6, pp. 19661 - 19670, http://dx.doi.org/10.18632/oncotarget.3875
2015
Giotopoulos G; van der Weyden L; Osaki H; Rust AG; Gallipoli P; Meduri E; Horton SJ; Chan WI; Foster D; Prinjha RK; Pimanda JE; Tenen DG; Vassiliou GS; Koschmieder S; Adams DJ; Huntly BJP, 2015, 'A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression', Journal of Experimental Medicine, vol. 212, pp. 1551 - 1569, http://dx.doi.org/10.1084/jem.20141661
2015
Jing RBAB, 2015, 'Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells', Blood, vol. 125, pp. 273 - 283, http://dx.doi.org/10.1182/blood-2014-05-576470
2015
Marks-Bluth J; Khanna A; Chandrakanthan V; Thoms J; Bee T; Eich C; Kang YC; Knezevic K; Qiao Q; Fitch S; Oxburgh L; Ottersbach K; Dzierzak E; de Bruijn MFTR; Pimanda JE, 2015, 'SMAD1 and SMAD5 expression is coordinately regulated by FLI1 and GATA2 during endothelial development', Molecular and Cellular Biology, vol. 35, pp. 2165 - 2172, http://dx.doi.org/10.1128/MCB.00239-15
2015
Poulos RC; Thoms JAI; Shah A; Beck D; Pimanda JE; Wong JWH, 2015, 'Systematic screening of promoter regions pinpoints functional cis-regulatory mutations in a cutaneous melanoma genome', Molecular Cancer Research, vol. 13, pp. 1218 - 1226, http://dx.doi.org/10.1158/1541-7786.MCR-15-0146
2015
Woll PS; Kjaellquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstroem-Lindberg E; Linnarsson S; Jacobsen SEW, 2015, 'Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)', CANCER CELL, vol. 27, pp. 603 - 605, http://dx.doi.org/10.1016/j.ccell.2015.03.003
2015
Woll PS; Kjällquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark SA; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Göhring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellström-Lindberg E; Linnarsson S; Jacobsen SEW, 2015, 'Erratum to Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo, [Cancer Cell, 25, 2014, 794-808]', Cancer Cell, vol. 27, pp. 603 - 605, http://dx.doi.org/10.1016/j.ccell.2015.03.003
2015
Rao TN; Marks-Bluth J; Sullivan J; Gupta MK; Chandrakanthan V; Fitch SR; Ottersbach K; Jang YC; Piao X; Kulkarni RN; Serwold T; Pimanda JE; Wagers AJ, 2015, 'High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice', Stem Cell Research, vol. 14, pp. 307 - 322, http://dx.doi.org/10.1016/j.scr.2015.02.001
2015
Nasrallah R; Knezevic K; Thai T; Thomas SR; Göttgens B; Lacaud G; Kouskoff V; Pimanda JE, 2015, 'Endoglin potentiates nitric oxide synthesis to enhance definitive hematopoiesis', Biology Open, vol. 4, pp. 819 - 829, http://dx.doi.org/10.1242/bio.011494
2015
Tursky ML; Beck D; Thoms JAI; Huang Y; Kumari A; Unnikrishnan A; Knezevic K; Evans K; Richards LA; Lee E; Morris J; Goldberg L; Izraeli S; Wong JWH; Olivier J; Lock RB; MacKenzie KL; Pimanda JE, 2015, 'Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias', Leukemia, vol. 29, pp. 819 - 827, http://dx.doi.org/10.1038/leu.2014.299
2015
Tobiasson M; Karimi M; Dimitriou M; Qu Y; Lennartsson A; Ali HA; Unnikrishnan A; Jadersten M; Jansson M; Ben Azenkoud A; Pimanda JE; Ekwall K; Ungerstedt J; Lehmann S; Hellstrom-Lindberg E, 2014, 'Mutations in Histone Modulators and HOXA5 Methylation Levels Affects Survival in Azacitidine Treated MDS Patients', BLOOD, vol. 124, http://www.bloodjournal.org/content/124/21/4613
2014
Nasrallah R; Knezevic K; Gottgens B; Lacaud G; Kouskoff V; Pimanda J, 2014, 'ENDOGLIN MODULATES STAGE SPECIFIC CELL RESPONSES DURING LINEAGE COMMITMENT FROM EMBRYONIC STEM CELLS TO BLOOD AND ENDOTHELIUM', EXPERIMENTAL HEMATOLOGY, vol. 42, pp. S54 - S54, http://dx.doi.org/10.1016/j.exphem.2014.07.203
2014
Chacon D; Beck D; Perera D; Wong JWH; Pimanda JE, 2014, 'BloodChIP: A database of comparative genome-wide transcription factor binding profiles in human blood cells', Nucleic Acids Research, vol. 42, http://dx.doi.org/10.1093/nar/gkt1036
2014
Woll PS; Kjaellquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstroem-Lindberg E; Linnarsson S; Jacobsen SEW, 2014, 'Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)', CANCER CELL, vol. 25, pp. 861 - 861, http://dx.doi.org/10.1016/j.ccr.2014.05.027
2014
Sloane MA; Wong JWH; Perera D; Nunez AC; Pimanda JE; Hawkins NJ; Sieber OM; Bourke MJ; Hesson LB; Ward RL, 2014, 'Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia', Epigenetics, vol. 9, pp. 1092 - 1100, http://dx.doi.org/10.4161/epi.29222
2014
Ju YSE; Alexandrov LB; Gerstung M; Martincorena I; Nik-Zainal S; Ramakrishna M; Davies HR; Papaemmanuil E; Gundem G; Shlien A; Bolli N; Behjati S; Tarpey PS; Nangalia J; Massie CE; Butler AP; Teague JW; Vassiliou GS; Green AR; Du MQ; Unnikrishnan A; Pimanda JE; Teh BTE; Munshi N; Greaves M; Vyas P; El-Naggar AK; Santarius T; Collins VP; Grundy R; Taylor JA; Hayes DN; Malkin D; Foster CS; Warren AY; Whitaker HC; Brewer D; Eeles R; Cooper C; Neal D; Visakorpi T; Isaacs WB; Bova GS; Flanagan AM; Futreal PA; Lynch AG; Chinnery PF; McDermott U; Stratton MR; Campbell PJ, 2014, 'Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer', eLife, vol. 3, http://dx.doi.org/10.7554/eLife.02935
2014
Diffner E; Beck D; Gudgin E; Thoms JAI; Knezevic K; Pridans C; Foster S; Goode D; Khong Lim W; Boelen L; Metzeler KH; Micklem G; Bohlander SK; Buske C; Burnett A; Ottersbach K; Vassiliou GS; Olivier J; Wong JWH; Gottgens B; Huntly BJ; Pimanda JE, 2014, 'Erratum: Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia (Blood (2013) 121:12 (2289-2300))', Blood, vol. 123, pp. 2901, http://dx.doi.org/10.1182/blood-2014-03-564831
2014
Perera D; Chacon D; Thoms JA; Poulos RC; Shlien A; Beck D; Campbell PJ; Pimanda JE; Wong JW, 2014, 'Oncocis: Annotation of cis-regulatory mutations in cancer', Genome Biology, vol. 15, http://dx.doi.org/10.1186/s13059-014-0485-0
2014
Oram SH; Thoms J; Sive J; Calero-Nieto FJ; Kinston SJ; Schuette J; Knezevic K; Lock RB; Pimanda JE; Gottgens B, 2013, 'Bivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia', Leukemia, vol. 27, pp. 1348 - 1357, http://dx.doi.org/10.1038/leu.2013.2
2013
Khanna A; Pimanda JE; Westermarck J, 2013, 'Cancerous inhibitor of protein phosphatase 2A, an emerging human oncoprotein and a potential cancer therapy target', Cancer Research, vol. 73, pp. 6548 - 6553, http://dx.doi.org/10.1158/0008-5472.CAN-13-1994
2013
Khanna A; Kauko O, Bockelman C, Laine A, Schreck I, Partanen JI, Szwajda A, Bormann S, Bilgen T, Helenius M, Pokharel YR, Pimanda J, Russel MR, Haglund C, Cole KA, Klefstrom J, Aittokallio T, Weiss C, Ristimaki A, Visakorpi T, Westermarck J. , 2013, 'Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cells.', Cancer Research, vol. 73, pp. 6757 - 6769, http://dx.doi.org/10.1158/0008-5472.CAN-13-1002
2013
Goldberg L; Tijssen MR; Birger Y; Hannah RL; Kinston SJ; Schütte J; Beck D; Knezevic K; Schiby G; Jacob-Hirsch J; Biran A; Kloog Y; Marcucci G; Bloomfield CD; Aplan PD; Pimanda JE; Göttgens B; Izraeli S, 2013, 'Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia', Blood, vol. 122, pp. 2694 - 2703, http://dx.doi.org/10.1182/blood-2013-01-477133
2013
Beck D; Thoms JAI; Perera D; Schütte J; Unnikrishnan A; Knezevic K; Kinston SJ; Wilson NK; O'Brien TA; Göttgens B; Wong JWH; Pimanda JE, 2013, 'Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes', Blood, vol. 122, pp. e12 - e22, http://dx.doi.org/10.1182/blood-2013-03-490425
2013
Hesson LB; Patil V; Sloane MA; Nunez AC; Liu J; Pimanda JE; Ward RL, 2013, 'Reassembly of Nucleosomes at the MLH1 Promoter Initiates Resilencing Following Decitabine Exposure', PLoS Genetics, vol. 9, http://dx.doi.org/10.1371/journal.pgen.1003636
2013
Narula J; Williams CJ; Tiwari A; Marks-Bluth J; Pimanda JE; Igoshin OA, 2013, 'Mathematical model of a gene regulatory network reconciles effects of genetic perturbations on hematopoietic stem cell emergence', Developmental Biology, vol. 379, pp. 258 - 269, http://dx.doi.org/10.1016/j.ydbio.2013.04.016
2013
Liu J; Hesson L; Meagher AP; Bourke MJ; Hawkins NJ; Rand KN; Molloy PL; Pimanda JE; Ward RL, 2012, 'Relative distribution of folate species is associated with global DNA methylation in human colorectal mucosa', CANCER PREVENTION RESEARCH, vol. 5, pp. 921 - 929, http://dx.doi.org/10.1158/1940-6207.CAPR-11-0577
2012
Beck D; Brandl MB; boelen L; Unnikrishnan A; Pimanda JE; Wong JWH, 2012, 'Signal analysis for genome-wide maps of histone modifications measured by ChIP-seq', Bioinformatics, vol. 28, pp. 1062 - 1069, http://dx.doi.org/10.1093/bioinformatics/bts085
2012
Pereira LA; Wong MS; Mossmann AK; Sourris K; Janes ME; Knezevic K; Hirst CE; Lim S; Pimanda JE; Stanley E; Elefanty A, 2012, 'Pdgfrá and Flk1 are direct target genes of Mixl1 in differentiating embryonic stem cells', Steam cell research, vol. 8, pp. 165 - 179, http://dx.doi.org/10.1016/j.scr.2011.09.007
2012
Pimanda JE, 2012, 'Concise Review: Blood Relatives: Formation and Regulation of Hematopoietic Stem Cells by the Basic Helix-Loop-Helix Transcription Factors Stem Cell Leukemia and Lymphoblastic Leukemia-Derived Sequence 1', Stem Cells, vol. 30, pp. 1053 - 1058, http://dx.doi.org/10.1002/stem.1093
2012
Pimanda JE, 2012, 'Cell signalling pathways that mediate haematopoietic stem cell specification', The International Journal of Biochemistry & Cell Biology, vol. 44, pp. 2175 - 2184, http://dx.doi.org/10.1016/j.biocel.2012.09.007
2012
Chong J; Chandrakanthan V; Xaymardan M; Asli NS; Li J; Ahmed I; Heffernan C; Menon M; Scarlett C; Rashidianfar A; Biben C; Zoellner H; Colvin EK; Pimanda JE; Biankin AV; Zhou B; Pu WT; Prall OWJ; Harvey RP, 2011, 'Adult cardiac-resident MSC-like stem cells with a proepicardial origin', Cell Stem Cell, vol. 9, pp. 527 - 540, http://dx.doi.org/10.1016/j.stem.2011.10.002
2011
Taoudi S; Bee T; Hilton A; Knezevic K; Scott J; Scott J; Willson TA; Collin C; Thomas T; Voss AK; Kile BT; Alexander WS; Pimanda JE; Hilton DJ, 2011, 'ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification', Genes and Development, vol. 25, pp. 251 - 262, http://dx.doi.org/10.1101/gad.2009211
2011
Thoms JAI; Birger Y; Foster S; Knezevic K; Kirshenbaum Y; Chandrakanthan V; Jonquieres G; Spensberger D; Wong JW; Oram SH; Kinston SJ; Groner Y; Lock RB; MacKenzie KL; Gottgens B; Izraeli S; Pimanda JE, 2011, 'ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer', Blood, vol. 117, pp. 7079 - 7089, http://dx.doi.org/10.1182/blood-2010-12-317990
2011
Pimanda J; Thoms J; Birger Y; Foster S; Knezevic K; Kirschenbaum Y; Chandrakanthan V; Lock R; MacKenzie K; Gottgens B; Izraeli S, 2011, 'ERG PROMOTES T-ACUTE LYMPHOBLASTIC LEUKEMIA AND IS TRANSCRIPTIONALLY REGULATED IN LEUKEMIC CELLS BY A STEM CELL ENHANCER', EXPERIMENTAL HEMATOLOGY, vol. 39, pp. S108 - S108, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000293801700179&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2011
Knezevic K; Wilson N; Bee T; Janes M; Kinston SJ; Polderdijk S; Kolb-Kokocinski A; Ottersbach K; Pencovich N; Groner Y; De bruijn M; Gottgens B; Pimanda JE, 2011, 'A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis', Molecular and Cellular Biology, vol. 31, pp. 2817 - 2826, http://dx.doi.org/10.1128/MCB.01305-10
2011
Wilson N; Foster S; Wang XL; Knezevic K; Schutte J; Kaimakis P; Chilarska P; Kinston S; Ouwehand AC; Dzierzak E; Pimanda JE; De bruijn M; Gottgens B, 2010, 'Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.', Cell Stem Cell, vol. 7, pp. 532 - 544, http://dx.doi.org/10.1016/j.stem.2010.07.016
2010
Oram SH; Thoms JAI; Pridans C; Janes ME; Kinston SJ; Anand S; Landry JR; Lock RB; Jayaraman PS; Huntly BJ; Pimanda JE; Gottgens B, 2010, 'A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients', Oncogene, vol. 29, pp. 5796 - 5808, http://dx.doi.org/10.1038/onc.2010.320
2010
Bachmann PS; Piazza RG; Janes M; Wong NC; Davies C; Mogavero A; Bhadri V; Szymanska B; Geninson G; Magistroni V; Cazaniga G; Biondi A; Miranda-saavedra D; Gottgens B; Saffery R; Craig JM; Marshall GM; Gambacorti-passerini C; Pimanda JE; Lock RB, 2010, 'Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition', Blood, vol. 116, pp. 3013 - 3022, http://dx.doi.org/10.1182/blood-2010-05-284968
2010
Wang B; Chen J; Santiago FS; Janes ME; Kavurma MM; Chong BH; Pimanda JE; Khachigian LM, 2010, 'Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription.', Arteriosclerosis, Thrombosis and Vascular Biology, vol. 30, pp. 536 - 545, http://dx.doi.org/10.1161/ATVBAHA.109.193821
2010
Pimanda JE; Gottgens B, 2010, 'Gene regulatory networks governing etic stem cell development and identity', International Journal of Developmental Biology, vol. 54, pp. 1201 - 1211, http://dx.doi.org/10.1387/ijdb.093038jp
2010
Landry J; Kinston S; Knezevic K; De bruijn M; Wilson N; Nottingham W; Peitz M; Edenhofer F; Pimanda JE; Ottersbach K; Gottgens B, 2008, 'Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver.', Blood, vol. 111, pp. 3005 - 3014, http://dx.doi.org/10.1182/blood-2007-07-098830
2008
Pimanda JE; Chan W; Wilson N; Smith A; Kinston S; Knezevic K; Janes M; Landry J; Kolb-Kokocinski A; Frampton J; Tannahill D; Ottersbach K; Follows G; Goettgens B; Lacaud G; Kouskoff V, 2008, 'Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code', Blood, vol. 112, pp. 4512 - 4522, http://dx.doi.org/10.1182/blood-2008-05-157560
2008
Chan W; Follows G; Lacaud G; Pimanda JE; Landry J; Kinston S; Knezevic K; Piltz S; Donaldson I; Gambardella L; Sablitzky F; Green AR; Kouskoff V; Gottgens B, 2007, 'The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype.', Blood, vol. 109, pp. 1908 - 1916, http://dx.doi.org/10.1182/blood-2006-05-023226
2007
Pimanda JE; Ottersbach K; Knezevic K; Kinston S; Chan W; Wilson N; Landry J; Kolb-Kokocinski A; Green AR; Tannahill D; Gottgens B, 2007, 'The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity.', Proceedings of the National Academy of Sciences of the United States of America, vol. 104, pp. 840 - 845, http://dx.doi.org/10.1073/pnas.0607196104
2007
Pimanda JE; Ottersbach K; Knezevic K; Kinston S; Chan W; Wilson N; Landry J; Wood A; Kolb-Kokocinski A; Green AR; Tannahill D; Lacaud G; Kouskoff V; Gottgens B, 2007, 'Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development', Proceedings of the National Academy of Sciences of the United States of America, vol. 104, pp. 17692 - 17697, http://dx.doi.org/10.1073/pnas.0707045104
2007
Pimanda JE; Silberstein L; Dominici M; Dekel B; Bowen M; Oldham M; Brandt S; Tannahill D; Gottgens B; Green AR, 2006, 'Transcriptional link between blood and bone: the stem cell leukemia gene and its +19 stem cell enhancer are active in bone cells', Molecular and Cellular Biology, vol. 26, pp. 2615 - 2625, http://dx.doi.org/10.1128/MCB.26.7.2615-2625.2006
2006
Schneppenheim R; Kremer hovinga J; Becker T; Budder U; Karpman D; Brockhaus W; Hrachovinová I; Korczowski B; Oyen F; Rittich S; von Rosen J; Tjønnfjord G; Pimanda JE; Wienker G; Lämmle B, 2006, 'A common origin of the 4143insA ADAMTS13 mutation', Thrombosis and Haemostasis, vol. 96, pp. 3 - 6, http://dx.doi.org/10.1160/TH05-12-0817
2006
Pimanda JE; Chan W; Donaldson I; Bowen M; Green AR; Gottgens B, 2006, 'Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a -8-kb enhancer', Blood, vol. 107, pp. 4737 - 4745, http://dx.doi.org/10.1182/blood-2005-12-4929
2006
Rainis L; Toki T; Pimanda JE; Rosenthal E; Machol E; Strehl S; Gottgens B; Ito E; Izraeli S, 2005, 'The proto-oncogene ERG in megakaryoblastic leukemias.', Cancer research, vol. 65, pp. 7596 - 7602, http://dx.doi.org/10.1158/0008-5472.CAN-05-0147
2005
Pimanda JE; Ganderton TR; Maekawa A; Yap C; Lawler J; Kershaw G; Chesterman CN; Hogg PJ, 2004, 'Role of thrombospondin-1 in control of von Willebrand factor multimer size in mice', The Journal of Biological Chemistry, vol. 279, pp. 21439 - 21448, http://dx.doi.org/10.1074/jbc.M313560200
2004
Pimanda JE; Maekawa A; Wind T; Paxton J; Chesterman CN; Hogg PJ, 2004, 'Congenital thrombotic thrombocytopenic purpura in association with a mutation in the second CUB domain of ADAMTS13', Blood, vol. 103, pp. 627 - 629, http://dx.doi.org/10.1182/blood-2003-04-1346
2004
Pimanda JE; Lowe HC; Hogg PJ; Chesterman CN; Khachigian LM, 2003, 'Novel and Emerging Therapies in Cardiology and Haematology', Current Drug Targets, vol. 3, pp. 101 - 103, http://dx.doi.org/10.2174/1568006033481465
2003
Pimanda JE; Chesterman CN; Hogg PJ, 2003, 'A perspective on the measurement of ADAMTS13 in thrombotic thrombocytopaenic purpura', European Journal of Haematology, vol. 70, pp. 257 - 262, http://dx.doi.org/10.1034/j.1600-0609.2003.00057.x
2003
Pimanda JE; Hogg PJ, 2002, 'Control of von Willebrand factor multimer size and implications for disease', Blood Reviews, vol. 16, pp. 185 - 192, http://dx.doi.org/10.1016/S0268-960X(02)00017-6
2002
Pimanda JE; Annis D; Raftery M; Mosher D; Chesterman CN; Hogg PJ, 2002, 'The von Willebrand factor-reducing activity of thrombospondin-1 is located in the calcium-binding/C-terminal sequence and requires a free thiol at position 974.', Blood, vol. 100, pp. 2832 - 2838, http://dx.doi.org/10.1182/blood-2002-03-0770
2002
Conference Papers
add
Jing D; Huang Y; Liu X; Sia K; Poulos RC; Span M; Zhang C; Mi J; Wong JWH; Beck D; Pimanda JE; Lock RB, 2018, 'Lymphocyte-specific chromatin accessibility predetermines glucocorticoid resistance in acute lymphoblastic leukemia', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Chicago, IL, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), Chicago, IL, 14 April 2018 - 18 April 2018, http://dx.doi.org/10.1158/1538-7445.AM2018-3173
2018
Ali A; Penneroux J; Dal Bello R; Masse A; Quentin S; Unnikrishnan A; Hernandez L; Raffoux E; Benabelali R; Renneville A; Preudhomme C; Pimanda J; Dombret H; Soulier J; Fenaux P; Clappier E; Ades L; Itzykson R, 2017, 'Granulomonocytic Progenitors (GMPs) Are Key Target Cells of Azacitidine in MDS and AML', in BLOOD, AMER SOC HEMATOLOGY, Atlanta, GA, presented at 59th Annual Meeting of the American-Society-of-Hematology (ASH), Atlanta, GA, 09 December 2017 - 12 December 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000432419401234&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2017
Kang YC; Glaros E; Thomas S; Qiao Q; Brownlee C; Pimanda J; Chandrakanthan V, 2017, 'Identification of Novel Embryonic Vascular Stem-like cells and their role in Coronary Vasculature development and repair', in MECHANISMS OF DEVELOPMENT, ELSEVIER SCIENCE BV, Natil Univ Singapore, Singapore, SINGAPORE, pp. S48 - S49, presented at 18th International Congress of Developmental Biology, Natil Univ Singapore, Singapore, SINGAPORE, 18 June 2017 - 22 June 2017, http://dx.doi.org/10.1016/j.mod.2017.04.088
2017
Unnikrishnan A; Papaemmanuil E; Beck D; Verma A; Kumari A; Woll P; Richards L; Knezevic K; Chandrakanthan V; Thoms J; Tursky ML; Huang Y; Ali Z; Olivier S; Galbraith S; Kulasekararaj A; Tobiasson M; Karimi M; Pellagatti A; Wilson S; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen S; Mufti G; Hellstrom-Lindberg E; MacKenzie K; Wong J; Campbell P; Pimanda J, 2016, 'Integrative genomics identifies the molecular basis of resistance to Azacitidine therapy in Myelodysplastic Syndromes', in Integrative genomics identifies the molecular basis of resistance to Azacitidine therapy in Myelodysplastic Syndromes, Ferrata Storti Foundation, Copenhagen, Denmark, pp. 157 - 158, presented at 21st Congress Of The European Hematology Association (EHA), Copenhagen, Denmark, 09 June 2016 - 12 June 2016, https://synapse.mskcc.org/synapse/works/97032
2016
Khanna A; Stringer B; Ensbey K; Jahaan Z; Boyd A; McDonald K; Day B; Pimanda J, 2015, 'Clinical relevance of DNA damage modulator checkpoint kinase 1 (CHK1) and cancerous inhibitor of protein phosphatase 2A (CIP2A) in human gliomas', in ANNALS OF ONCOLOGY, OXFORD UNIV PRESS, Singapore, SINGAPORE, pp. 34 - 34, presented at Asia Congress of the European-Society-for-Medical-Oncology (ESMO), Singapore, SINGAPORE, 18 December 2015 - 21 December 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000367158700117&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2015
Unnikrishnan A; Papaemmanuil E; Beck D; Kumari A, 2015, 'An Integrative Genomics Approach Uncovers the Basis of Resistance to AZA Therapy in MDS and CMML', in An Integrative Genomics Approach Uncovers the Basis of Resistance to, AMER SOC HEMATOLOGY, USA, presented at ASH Annual Meeting, USA, 05 December 2015 - 08 December 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000368019002147&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2015
Avellino R; Havermans M; Erpelinck C; Sanders M; Groeschel S; Vandewerken H; Hoogenboezem RM; Rombouts E; Van Lom K; Van Strien P; De Looper H; Gebhard CC; Rehli M; Beck D; Thoms JAI; Erkeland S; Touw I; Pimanda JE; Bindels EJM; Delwel R, 2015, 'A Tissue-Specific Transcriptional Element for C/ebpa Is Required for HSC Maintenance and Neutrophil Development', in BLOOD, AMER SOC HEMATOLOGY, Orlando, FL, presented at 57th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, 05 December 2015 - 08 December 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000368019001053&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2015
Unnikrishnan A; Beck D; Verma A; Richards LA; Thoms JAI; Kumari A; Galbraith S; Kulasekararaj A; Tobiasson M; Woll PS; Pellagatti A; Papaemmanuil E; Wilson SR; Lindeman R; Campbell PJ; Boultwood J; Lynch K; Jacobsen SEW; Mufti GJ; Hellstrom-Lindberg E; MacKenzie KL; Wong JWH; Pimanda JE, 2014, 'Identification of a Prognostic Gene Expression Signature for AZA Response in MDS and CMML Patients', in BLOOD, AMER SOC HEMATOLOGY, San Francisco, CA, presented at 56th Annual Meeting of the American-Society-of-Hematology, San Francisco, CA, 06 December 2014 - 09 December 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349243501166&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2014
Beck D; Palu C; Shah A; Herold T; Olivier J; Valk PJM; Delwel R; Bohlander SK; Wong JW; Pimanda JE, 2014, 'Integrative Analysis of Lincrna Expression and Clinical Annotations Reveals a Signature of 17 Genes with Prognostic Significance in Acute Myeloid Leukemia (AML)', in BLOOD, AMER SOC HEMATOLOGY, San Francisco, CA, presented at 56th Annual Meeting of the American-Society-of-Hematology, San Francisco, CA, 06 December 2014 - 09 December 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349243503093&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2014
Donald MR; Unnikrishnan A; Pimanda JE; Wilson S, 2013, 'Model Comparisons for RNA-Seq Data', in Proceedings of the 28th International Workshop on Statistical Modelling, 28th International Workshop on Statistical Modelling, Palermo, Italy, pp. 563 - 566, presented at 28th International Workshop on Statistical Modelling, Palermo, Italy, 08 July 2013 - 12 July 2014
2013
Beck D; Thoms J; Perera D; Unnikrishnan A; Knezevic K; O'Brien T; Gottgens B; Wong J; Pimanda J, 2013, 'GENOME-WIDE ANALYSIS OF TRANSCRIPTIONAL REGULATORS IN HUMAN HSCS REVEALS A DENSELY INTERCONNECTED NETWORK OF CODING AND NON-CODING GENES', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Vienna, AUSTRIA, pp. S17 - S17, presented at 42nd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology-and-Stem-Cells (ISEH), Vienna, AUSTRIA, 22 August 2013 - 25 August 2013, http://dx.doi.org/10.1016/j.exphem.2013.05.063
2013
Nasrallah R; Knezevic K; Janes M; Smith A; Gottgens B; Lacaud G; Kouskoff V; Pimanda J, 2013, 'ENRICHING HEMANGIOBLAST AND HEMOGENIC ENDOTHELIAL CELLS USING REGULATORY ELEMENTS OF THE ENDOGLIN GENE', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Vienna, AUSTRIA, pp. S72 - S72, presented at 42nd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology-and-Stem-Cells (ISEH), Vienna, AUSTRIA, 22 August 2013 - 25 August 2013, http://dx.doi.org/10.1016/j.exphem.2013.05.281
2013
Kumari A; Richards LA; Jonquieres G; Knezevic K; O'Brien R; Napier CE; Marks-Bluth J; Pickett H; Pimanda JE; MacKenzie KL, 2012, 'Dyskerin Is Upregulated During Erythroid Differentiation of Human Hematopoietic Progenitor Cells and Hyperactivates Telomerase in Erythroid Precursor Cells', in BLOOD, AMER SOC HEMATOLOGY, Atlanta, GA, presented at 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Atlanta, GA, 08 December 2012 - 11 December 2012, http://dx.doi.org/10.1182/blood.V120.21.980.980
2012
Pimanda J; Knezevic K; Bee T; Janes M; Thoms J; Wilson N; Kolb-Kokocinski A; Pencovic N; Groner Y; de Bruijn M; Goettgens B, 2010, 'A RUNX1-SMAD6 RHEOSTAT CONTROLS RUNX1 LEVELS AND REGULATES HEMATOPOIESIS IN THE DEVELOPING EMBRYO', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Melbourne, AUSTRALIA, pp. S17 - S18, presented at 39th Annual Scientific Meeting of the ISEH - Society-for-Hematology-and-Stem-Cells, Melbourne, AUSTRALIA, 15 September 2010 - 18 September 2010, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000281168900035&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2010
Lock RB; Bachmann PS; Piazza RG; Davies C; James M; Wong NC; Bhadri VA; Mogavero A; Magistroni V; Gambacorti-Passerini C; Saffery R; Craig JM; Pimanda JE; Marshall GM, 2009, 'Epigenetic Silencing of the Pro-Apoptotic Bim Gene in Glucocorticoid Poor-Responsive Pediatric Acute Lymphoblastic Leukemia, and Its Reversal by Histone Deacetylase Inhibition', in BLOOD, AMER SOC HEMATOLOGY, New Orleans, LA, pp. 387 - 388, presented at 51st Annual Meeting of the American-Society-of-Hematology, New Orleans, LA, 05 December 2009 - 08 December 2009, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000272725801119&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2009
Pimanda J; Ottersbach K; Knezevic K; Kinston S; Landry J; Wood A; Kolb-Kokocinsky A; Green A; Tannahill D; Gottgens B, 2007, 'GATA2, Fli1 and SCL form a recursively wired gene regulatory circuit in developing blood stem cells', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Hamburg, GERMANY, pp. 55 - 56, presented at 36th Annual Meeting of the International-Society-for-Experimental-Hematology, Hamburg, GERMANY, 28 September 2007 - 30 September 2007, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000249535200149&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2007
Pimanda J; Ottersbach K; Knezevic K; Kinston S; Landry T; Wood A; Kolb-Kolocinsky A; Green A; Tannahill D; Gottgens B, 2007, 'GATA2, FLI1 and SCL form a recursively wired gene regulatory circuit in developing blood stem cells', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Hamburg, GERMANY, pp. 25 - 25, presented at 36th Annual Meeting of the International-Society-for-Experimental-Hematology, Hamburg, GERMANY, 28 September 2007 - 30 September 2007, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000249535200059&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2007
Pimanda JE; Donaldson IJ; de Bruijn MFTR; Kinston S; Knezevic K; Huckle L; Piltz S; Landry J-R; Green AR; Tannahill D; Goettgens B, 2007, 'Genome-wide computational screen for bloon stem cell enhancers integrates RUNX1 and the BMP signaling pathway into the SCL transcriptional network', in BLOOD CELLS MOLECULES AND DISEASES, ACADEMIC PRESS INC ELSEVIER SCIENCE, St Johns Coll, Oxford, ENGLAND, pp. 172 - 173, presented at 15th Conference on Hemoglobin Switching, St Johns Coll, Oxford, ENGLAND, 14 September 2006 - 18 September 2006, http://dx.doi.org/10.1016/j.bcmd.2006.10.119
2007
Pimanda JE; Donaldson IJ; Bruijn MF; Kinston SJ; Knezevic K; Huckle L; Piltz S; Landry J-R; Green AR; Tannahill D; Gottgens B, 2006, 'Genome-wide computational screen for blood stem cell enhancers integrates RUNX1 and the BMP signaling pathway into the SCL transcriptional network.', in BLOOD, AMER SOC HEMATOLOGY, Orlando, FL, pp. 129B - 129B, presented at 48th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, 09 December 2006 - 12 December 2006, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000242440400476&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2006
Silberstein L; Pimanda JE; Piltz S; Delaney L; Oldham S; Kallianpur A; Dominici M; Brandt S; Gottgens B; Green A, 2004, 'A role for SCL in developing bone? the SCL+19 core enhancer targets expression to cells of developing bone, osteocytes, chondrocytes and bone lining cells', in BLOOD, AMER SOC HEMATOLOGY, San Diego, CA, pp. 136B - 136B, presented at 46th Annual Meeting of the American-Society-of-Hematology, San Diego, CA, 04 December 2004 - 07 December 2004, http://dx.doi.org/10.1182/blood.V104.11.4199.4199
2004
Pimanda JE; Annis DS; Raftery MJ; Mosher DF; Chesterman CN; Hogg PJ, 2002, 'The von Willebrand factor reducing activity of thrombospondin-1 centers around a free thiol at position 974.', in BLOOD, AMER SOC HEMATOLOGY, PHILADELPHIA, PENNSYLVANIA, pp. 257A - 258A, presented at 44th Annual Meeting of the American-Society-of-Hematology, PHILADELPHIA, PENNSYLVANIA, 06 December 2002 - 10 December 2002, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000179184700981&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2002
Conference Abstracts
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Schwarzer A; Emmrich S; Beck D; Schmidt F; Ng M; Adams FF; Witte D; Kaebler S; Wong JWH; Shah A; Jammal R; Maroz A; Reimer C; Pimanda JE; Reinhardt D; Heckl D; Klusmann J-H, 2017, 'Mapping the Lncrna-Landscape of Human Hematopoiesis and Leukemia Reveals Stem Cell Non-Coding Gene Expression Programs', in ANNALS OF HEMATOLOGY, SPRINGER, Vol. 96, pp. S51 - S51, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000394105400047&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2017
Unnikrishnan A; Quynh AVN; Pickford R; Nunez A; Hesson L; Pimanda J, 2017, 'A NOVEL MASS SPECTROMETRY METHOD REVEALS THE INTRACELLULAR PHARMACOKINETICS OF AZACYTIDINE THERAPY IN VIVO', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, Madrid, SPAIN, Vol. 102, pp. 258 - 259, presented at 22nd Congress of the European-Hematology-Association, Madrid, SPAIN, 22 June 2017 - 25 June 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000404127002145&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2017
Beck D; Thoms J; Palu C; Herold T; Shah A; Olivier J; Boelen L; Huang Y; Chacon D; Brown A; Babic M; Hahn C; Perugini M; Zhou X; Huntly B; Berdel W; Woermann B; Buechner T; Hiddemann W; Bohlander S; Scott H; Lewis I; D'Andrea R; Wong J; Pimanda J, 2016, 'INTEGRATIVE ANALYSIS OF LINCRNA EXPRESSION IN 922 ACUTE MYELOID LEUKEMIA PATIENTS REVEALS MULTIPLE PROGNOSTIC GENE SIGNATURES', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, Copenhagen, DENMARK, Vol. 101, pp. 208 - 209, presented at 21st Congress of the European-Hematology-Association, Copenhagen, DENMARK, 09 June 2016 - 12 June 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484600457&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2016
Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A; Villanueva JE; Nunez AC; Knezevic K; Palu C; Nasrallah R; Carnell M; Macmillan A; Whan R; Yu Y; Hardy P; Grey ST; Gladbach A; Delerue F; Ittner L; Mobbs R; Walkley CR; Purton LE; Ward RL; Wong JWH; Hesson LB; Walsh W; Pimanda JE, 2016, 'PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 113, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113
2016
Qiao Q; Chandrakanthan V; Pimanda J, 2015, 'CHARACTERISTICS OF STROMAL STEM CELLS IN THE FOETAL LIVER', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Kyoto, JAPAN, Vol. 43, pp. S90 - S90, presented at 44th Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Kyoto, JAPAN, 17 September 2015 - 19 September 2015, http://dx.doi.org/10.1016/j.exphem.2015.06.234
2015
Chandrakanthan V; Knezevic K; Kang YC; Qiao Q; Pimanda J, 2015, 'GENETIC FATE MAPPING OF MESENCHYMAL STEM-LIKE CELLS IN THE AORTA-GONAD MESONEPHROS (AGM) AND THEIR CONTRIBUTION TO DEVELOPMENTAL HEMATOPMESIS', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Kyoto, JAPAN, Vol. 43, pp. S46 - S46, presented at 44th Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Kyoto, JAPAN, 17 September 2015 - 19 September 2015, http://dx.doi.org/10.1016/j.exphem.2015.06.054
2015
Khanna A; Stringer B; Day B; Ensbey K; Shen H; Boyd A; McDonald KL; Pimanda J, 2014, 'Keeping GBM in check by targeting CHK1-CIP2A axis', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, Chicago, IL, Vol. 32, presented at 50th Annual Meeting of the American-Society-of-Clinical-Oncology, Chicago, IL, 30 May 2014 - 03 June 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000358613202702&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2014
Conference Presentations
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Khanna A; Stringer B; Day B; Ensbey K; Shen H; Boyd A; McDonald K; Pimanda JE, 2014, 'Keeping glioblastoma (GBM) in check by targeting the CHK1-STAT3-CIP2A axis', Vol. 74, presented at 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), San Diego, CA, 05 April 2014 - 09 April 2014, http://dx.doi.org/10.1158/1538-7445.AM2014-1600
2014
Diffner E; Beck D; Gudgin E; Thoms J; Knezevic K; Pridans C; Foster S; Goode D; Lim WK; Boelen L; Metzeler KH; Micklem G; Bohlander SK; Buske C; Burnett AK; Ottersbach K; Vassiliou G; Olivier J; Wong JWH; Gottgens B; Huntly B; Pimanda JE, 2012, 'Activity of a Heptad of Transcription Factors Is Associated with Stem Cell Programs and Clinical Outcome in Acute Myeloid Leukaemia', Vol. 120, presented at 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Atlanta, GA, 08 December 2012 - 11 December 2012, http://dx.doi.org/10.1182/blood.V120.21.3525.3525
2012

Epigenetic Changes Associated with Pharmacotherapy in Myelodysplasia, identifying critical components of the haematopoietic and mesenchymal stem cell transcriptional network and their interactions with cell surface receptors and cell signalling pathways.