Jeremy Henson

Senior Research Fellow

Dr Henson’s first scientific interest was theoretical physics and he initially chose a university degree that allowed him to study both theoretical physics and medicine. In his first year at university he developed a fascination with cellular mortality/immortality mechanisms. Dr Henson graduated from UNSW in 1998 with an MBBS and a BSc that included two honours degrees (Pure Mathematics and Molecular Biology) and four majors. During this time he was also self-author/publisher, of the Don’t Panic study guide that sold over 10,000 copies. Since graduating, Dr Henson he has worked as a clinician for 15 years, and has been a Career Medical Officer at Westmead Private Hospital since 2005. In 2007, Dr Henson completed his PhD on the ALT cancer immortality mechanism at the University of Sydney School of Medicine, and worked as a post-doctoral fellow at the Children’s Medical Research Institute for 7 years, where he correctly predicted the presence of a completely novel type of biomarker for the ALT immortality mechanism and invented the only quantitative assay for ALT cancer activity. Dr Henson now leads the Cancer Cell Immortality group in the Adult Cancer Program, Prince of Wales Clinical School, UNSW Medicine, which is generating novel cancer therapeutics and diagnostics based on Dr Henson’s discoveries. Dr Henson is a member of the Translational Cancer Research Network. 

publications

Journal articles
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Udugama M; Sanij E; Voon HPJ; Son J; Hii L; Henson JD; Lyn Chan F; Chang FTM; Liu Y; Pearson RB; Kalitsis P; Mann JR; Collas P; Hannan RD; Wong LH, 2018, 'Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, pp. 4737 - 4742, http://dx.doi.org/10.1073/pnas.1720391115
2018
Henson JD; Lau LM; Koch S; Martin La Rotta N; Dagg RA; Reddel RR, 2017, 'The C-Circle Assay for alternative-lengthening-of-telomeres activity', Methods, vol. 114, pp. 74 - 84, http://dx.doi.org/10.1016/j.ymeth.2016.08.016
2017
Dagg RA; Pickett HA; Neumann AA; Napier CE; Henson JD; Teber ET; Arthur JW; Reynolds CP; Murray J; Haber M; Sobinoff AP; Lau LMS; Reddel RR, 2017, 'Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres', Cell Reports, vol. 19, pp. 2544 - 2556, http://dx.doi.org/10.1016/j.celrep.2017.05.087
2017
Sobinoff AP; Allen JAM; Neumann AA; Yang SF; Walsh ME; Henson JD; Reddel RR; Pickett HA, 2017, 'BLM and SLX4 play opposing roles in recombination-dependent replication at human telomeres', EMBO Journal, vol. 36, pp. 2907 - 2919, http://dx.doi.org/10.15252/embj.201796889
2017
Silva H; Halvorsen D; Henson JD, 2015, 'Control ALT, delete cancer', Scientist, vol. 29
2015
Lau LMS; Dagg RA; Henson JD; Au AYM; Royds JA; Reddel RR, 2013, 'Detection of alternative lengthening of telomeres by telomere quantitative PCR', Nucleic Acids Research, vol. 41, http://dx.doi.org/10.1093/nar/gks781
2013
Pickett HA; Henson JD; Au AYM; Neumann AA; Reddel RR, 2011, 'Normal mammalian cells negatively regulate telomere length by telomere trimming', Human Molecular Genetics, vol. 20, pp. 4684 - 4692, http://dx.doi.org/10.1093/hmg/ddr402
2011
Henson JD; Reddel RR, 2010, 'Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers', FEBS Letters, vol. 584, pp. 3800 - 3811, http://dx.doi.org/10.1016/j.febslet.2010.06.009
2010
Henson JD, 2010, 'For cancers there is more to life than a longer G-strand', Asian Journal of Andrology, vol. 12, pp. 779 - 782, http://dx.doi.org/10.1038/aja.2010.103
2010
McDonald KL; McDonnell J; Muntoni A; Henson JD; Hegi ME; Von Deimling A; Wheeler HR; Cook RJ; Biggs MT; Little NS; Robinson BG; Reddel RR; Royds JA, 2010, 'Presence of alternative lengthening of telomeres mechanism in patients with glioblastoma identifies a less aggressive tumor type with longer survival', Journal of Neuropathology and Experimental Neurology, vol. 69, pp. 729 - 736, http://dx.doi.org/10.1097/NEN.0b013e3181e576cf
2010
Henson JD; Cao Y; Huschtscha LI; Chang AC; Au AYM; Pickett HA; Reddel RR, 2009, 'DNA C-circles are specific and quantifiable markers of alternative- lengthening-of-telomeres activity', Nature Biotechnology, vol. 27, pp. 1181 - 1185, http://dx.doi.org/10.1038/nbt.1587
2009
Costa A; Daidone MG; Daprai L; Villa R; Cantù S; Pilotti S; Mariani L; Gronchi A; Henson JD; Reddel RR; Zaffaroni N, 2006, 'Telomere maintenance mechanisms in liposarcomas: Association with histologic subtypes and disease progression', Cancer Research, vol. 66, pp. 8918 - 8924, http://dx.doi.org/10.1158/0008-5472.CAN-06-0273
2006
Jiang WQ; Zhong ZH; Henson JD; Neumann AA; Chang ACM; Reddel RR, 2005, 'Erratum: Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex (Molecular and Cellular Biology (2005) 25:7 (2708-2721))', Molecular and Cellular Biology, vol. 25, pp. 4334, http://dx.doi.org/10.1128/MCB.25.10.4334.2005
2005
Henson JD; Hannay JA; McCarthy SW; Royds JA; Yeager TR; Robinson RA; Wharton SB; Jellinek DA; Arbuckle SM; Yoo J; Robinson BG; Learoyd DL; Stalley PD; Bonar SF; Yu D; Pollock RE; Reddel RR, 2005, 'A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas', Clinical Cancer Research, vol. 11, pp. 217 - 225
2005
Jiang WQ; Zhong ZH; Henson JD; Neumann AA; Chang ACM; Reddel RR, 2005, 'Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex', Molecular and Cellular Biology, vol. 25, pp. 2708 - 2721, http://dx.doi.org/10.1128/MCB.25.7.2708-2721.2005
2005
Jeyapalan JN; Varley H; Foxon JL; Pollock RE; Jeffreys AJ; Henson JD; Reddel RR; Royle NJ, 2005, 'Activation of the ALT pathway for telomere maintenance can affect other sequences in the human genome', Human Molecular Genetics, vol. 14, pp. 1785 - 1794, http://dx.doi.org/10.1093/hmg/ddi185
2005
Henson JD; Neumann AA; Yeager TR; Reddel RR, 2002, 'Alternative lengthening of telomeres in mammalian cells', Oncogene, vol. 21, pp. 598 - 610, http://dx.doi.org/10.1038/sj/onc/1205058
2002
Conference Abstracts
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Malykh AG; Doyle JR; Tian F; Lee JHY; Henson JD; Reddel RR, 2015, 'Identification of new alternative lengthening of telomeres (ALT)-positive cancer cell lines using the C-circle assay', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Philadelphia, PA, Vol. 75, presented at 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Philadelphia, PA, 18 April 2015 - 22 April 2015, http://dx.doi.org/10.1158/1538-7445.AM2015-3768
2015
Gupta R; Dong Y; Solomon PD; Wettersten HI; Cheng CJ; Min JN; Henson J; Dogra SK; Hwang SH; Hammock BD; Zhu LJ; Reddel RR; Saltzman WM; Weiss RH; Chang S; Green MR; Wajapeyee N, 2014, 'Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A', in Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, http://dx.doi.org/10.1073/pnas.1411370111
2014
Lee JH; Reddel RR; Henson JD, 2014, 'THE C-CIRCLE ASSAY AS A BLOOD TEST FOR ALT CANCER ACTIVITY', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, Vol. 10, pp. 12 - 12, http://dx.doi.org/10.1111/ajco.12284
2014
McDonald K; McDonnell J; Muntoni A; Henson J; Hegi M; Wheeler H; Cook R; Biggs M; Little N; Robinson B; Jellinek D; Reddel R; Royds J, 2010, 'LONGER SURVIVAL FOR PATIENTS WITH ALTERNATIVE LENGTHENING OF TELOMERES (ALT) GLIOBLASTOMA MULTIFORME IS DUE TO A LESS AGGRESSIVE PHENOTYPE AND NOT TO IMPROVED RESPONSE TO ADJUVANT THERAPY', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Glasgow, SCOTLAND, Vol. 12, pp. 3 - 3, presented at Meeting of the British-Neuro-Oncology-Society, Glasgow, SCOTLAND, 23 June 2010 - 25 June 2010, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000279583000012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2010
McDonald KL; McDonnell J; Henson J; Muntoni A; Wheeler HR; Robinson BG; Reddel RR; Royds J, 2009, 'PRESENCE OF AN ALTERNATIVE LENGTHENING OF TELOMERE (ALT) MECHANISM AS A FAVORABLE PROGNOSTIC MARKER IN PATIENTS WITH GLIOBLASTOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Yokohama, JAPAN, Vol. 11, pp. 928 - 928, presented at 3rd Quadrennial Meeting of the World-Federation-of-Neuro-Oncoloyg/6th Meeting of the Asian-Society-for-Neuro-Oncology, Yokohama, JAPAN, 11 May 2009 - 14 May 2009, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000272974100244&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2009
McDonald KL; McDonnell J; Henson J; Muntoni A; Wheeler HR; Robinson BG; Reddel RR; Royds J, 2009, 'PRESENCE OF AN ALTERNATIVE LENGTHENING OF TELOMERE (ALT) MECHANISM AS A FAVORABLE PROGNOSTIC MARKER IN PATIENTS WITH GLIOBLASTOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Yokohama, JAPAN, Vol. 11, pp. 897 - 897, presented at 3rd Quadrennial Meeting of the World-Federation-of-Neuro-Oncoloyg/6th Meeting of the Asian-Society-for-Neuro-Oncology, Yokohama, JAPAN, 11 May 2009 - 14 May 2009, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000272974100111&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2009
Jiang WQ; Zhong ZH; Nguyen A; Henson JD; Toouli CD; Braithwaite AW; Reddel RR, 2009, 'Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins', in Journal of Cell Biology, Vol. 185, pp. 797 - 810, http://dx.doi.org/10.1083/jcb.200810084
2009
Jiang WQ; Zhong ZH; Henson JD; Reddel RR, 2007, 'Identification of candidate alternative lengthening of telomeres genes by methionine restriction and RNA interference', in Oncogene, Vol. 26, pp. 4635 - 4647, http://dx.doi.org/10.1038/sj.onc.1210260
2007