Chantelle Ahlenstiel

Senior Research Fellow

Dr Ahlenstiel completed her B.Adv.Sc (Hons) in 2000 at the University of Sydney and her PhD at the Westmead Institute for Medical Research, USyd in 2004.  Chantelle was awarded an NIH Visting Fellowship award to undertake postdoctoral training at the Vaccine Research Center, NIH.  In 2009, she moved to the University of New South Wales in the Immunvirology & Pathogenesis Program at the Kirby Institute, where she studies RNA-directed epigenetic silencing of HIV-1 and SIV.

Journal articles
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Read SA; Obeid S; Ahlenstiel C; Ahlenstiel G, 2019, 'The Role of Zinc in Antiviral Immunity', Advances in Nutrition, vol. 10, pp. 696 - 710, http://dx.doi.org/10.1093/advances/nmz013
2019
Ahlenstiel CL; Turville SG, 2019, 'Delivery of gene therapy to resting immune cells for an HIV cure', Current Opinion in HIV and AIDS, vol. 14, pp. 129 - 136, http://dx.doi.org/10.1097/COH.0000000000000531
2019
Tsukamoto T; Kariya R; Marks K; Hattori S; Ahlenstiel C; Symonds G; Okada S; Kelleher AD, 2018, 'Erratum: Transcriptional gene silencing limits CXCR4-associated depletion of bone marrow CD34R cells in HIV-1 infection (AIDS (2018) (2018) 32 (1737–1747) DOI: 10.1097/QAD.0000000000001882)', AIDS, vol. 32, pp. 2857 - 2858, http://dx.doi.org/10.1097/01.aids.0000547984.16868.93
2018
Tsukamoto T, 2018, 'Transcriptional gene silencing limits CXCR4-associated depletion of bone marrow CD34(+) cells in HIV-1 infection', AIDS, vol. 32, pp. 1737 - 1747, http://dx.doi.org/10.1097/QAD.0000000000001882
2018
Méndez C; Ledger S; Petoumenos K; Ahlenstiel C; Kelleher AD, 2018, 'RNA-induced epigenetic silencing inhibits HIV-1 reactivation from latency', Retrovirology, vol. 15, http://dx.doi.org/10.1186/s12977-018-0451-0
2018
Read SA; O'Connor KS; Suppiah V; Ahlenstiel CLE; Obeid S; Cook KM; Cunningham A; Douglas MW; Hogg PJ; Booth D; George J; Ahlenstiel G, 2017, 'Zinc is a potent and specific inhibitor of IFN-λ3 signalling', Nature Communications, vol. 8, http://dx.doi.org/10.1038/ncomms15245
2017
Klemm V; Mitchell J; Cortez-Jugo C; Cavalieri F; Symonds G; Caruso F; Kelleher AD; Ahlenstiel C, 2016, 'Achieving HIV-1 control through RNA-directed gene regulation', Genes, vol. 7, http://dx.doi.org/10.3390/genes7120119
2016
McAllery SA; Ahlenstiel CL; Suzuki K; Symonds GP; Kelleher AD; Turville SG, 2016, 'The feasibility of incorporating Vpx into lentiviral gene therapy vectors', Molecular Therapy - Methods and Clinical Development, vol. 3, pp. 16066, http://dx.doi.org/10.1038/mtm.2016.66
2016
Méndez C; Ahlenstiel CL; Kelleher AD, 2015, 'Post-transcriptional gene silencing, transcriptional gene silencing and human immunodeficiency virus.', World J Virol, vol. 4, pp. 219 - 244, http://dx.doi.org/10.5501/wjv.v4.i3.219
2015
Ahlenstiel C; Mendez C; Lim STH; Marks K; Turville S; Cooper DA; Kelleher AD; Suzuki K, 2015, 'Novel RNA duplex locks HIV-1 in a latent state via chromatin-mediated transcriptional silencing', Molecular Therapy - Nucleic Acids, vol. 4, pp. e261, http://dx.doi.org/10.1038/mtna.2015.31
2015
Ahlenstiel CL; Suzuki K; Marks K; Symonds GP; Kelleher AD, 2015, 'Controlling HIV-1: Non-coding RNA gene therapy approaches to a functional cure', Frontiers in Immunology, vol. 6, http://dx.doi.org/10.3389/fimmu.2015.00474
2015
Suzuki K; Ahlenstiel C; Marks K; Kelleher AD, 2015, 'Promoter targeting RNAs: Unexpected contributors to the control of HIV-1 transcription', Molecular Therapy - Nucleic Acids, vol. 4, http://dx.doi.org/10.1038/mtna.2014.67
2015
Suzuki K; Hattori S; Marks K; Ahlenstiel C; Maeda Y; Ishida T; Millington M; Boyd M; Symonds G; Cooper DA; Okada S; Kelleher AD, 2013, 'Promoter Targeting shRNA Suppresses HIV-1 Infection In vivo Through Transcriptional Gene Silencing', Molecular Therapy - Nucleic Acids, vol. 2, pp. e137, http://dx.doi.org/10.1038/mtna.2013.64
2013
Ahlenstiel C; Lim HGW; Cooper DA; Ishida T; Kelleher AD; Suzuki K, 2012, 'Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinary in human cells', Nucleic Acids Research, vol. 40, pp. 1579 - 1595, http://dx.doi.org/10.1093/nar/gkr891
2012
Swaminathan S; Suzuki K; Seddiki N; Kaplan W; Cowley MJ; Hood CL; Clancy JL; Murray DD; Mendez Ortega C; Gelgor L; Anderson B; Roth N; Cooper DA; Kelleher AD, 2012, 'Differential regulation of the Let-7 family of microRNAs in CD4+ T cells alters IL-10 expression.', Journal of Immunology, vol. 188, pp. 6238 - 6246, http://dx.doi.org/10.4049/jimmunol.1101196
2012
Suzuki K; Yamagishi M; Ahlenstiel C; Swaminathan S; Marks K; Murray D; McCartney EM; Beard MR; Alexander M; Purcell DFJ; Cooper DA; Watanabe T; Kelleher AD, 2011, 'Transcriptional gene silencing of HIV-1 through promoter targeted RNA is highly specific', RNA Biology, vol. 8, pp. 1035 - 1046, http://dx.doi.org/10.4161/rna.8.6.16264
2011
Suzuki K; Ishida T; Yamagishi M; Ahlenstiel C; Swaminathan S; Marks K; Murray D; McCartney EM; Beard MR; Alexander M; Purcell DF; Cooper DA; Watanabe T; Kelleher AD, 2011, 'Transcriptional gene silencing of HIV-1 through promoter targeted RNA is highly specific.', RNA biology, vol. 8, pp. 1035 - 1046
2011
Hood CL; Abraham J; Boyington JC; Leung K; Kwong PD; Nabel GJ, 2010, 'Biochemical and structural characterization of cathepsin L-processed Ebola virus glycoprotein: Implications for viral entry and immunogenicity', Journal of Virology, vol. 84, pp. 2972 - 2982, http://dx.doi.org/10.1128/JVI.02151-09
2010
Swaminathan S; Hood CL; Suzuki K; Kelleher AD, 2010, 'RNA duplexes in transcriptional regulation', Biomolecular Concepts, vol. 1, pp. 285 - 296, http://dx.doi.org/10.1515/bmc.2010.021
2010
Kong WP; Hood C; Yang ZY; Wei CJ; Xu L; García-Sastre A; Tumpey TM; Nabel GJ, 2006, 'Protective immunity to lethal challenge of the 1918 pandemic influenza virus by vaccination', Proceedings of the National Academy of Sciences of the United States of America, vol. 103, pp. 15987 - 15991, http://dx.doi.org/10.1073/pnas.0607564103
2006
Hood C; Cunningham AL; Slobedman B; Arvin AM; Sommer MH; Kinchington PR; Abendroth A, 2006, 'Varicella-Zoster virus ORF63 inhibits apoptosis of primary human neurons', Journal of Virology, vol. 80, pp. 1025 - 1031, http://dx.doi.org/10.1128/JVI.80.2.1025-1031.2006
2006
Hood C; Cunningham AL; Slobedman B; Boadle RA; Abendroth A, 2003, 'Varicella-Zoster Virus-Infected Human Sensory Neurons Are Resistant to Apoptosis, yet Human Foreskin Fibroblasts Are Susceptible: Evidence for a Cell-Type-Specific Apoptotic Response', Journal of Virology, vol. 77, pp. 12852 - 12864, http://dx.doi.org/10.1128/JVI.77.23.12852-12864.2003
2003
Conference Abstracts
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Suzuki K; Ahlenstiel C; Marks K; Cooper DA; Kelleher A, 2015, 'RNA TARGETING PROMOTER REGION INHIBITS ACTIVATION OF LATENTLY INFECTED HIV-1', in JOURNAL OF GENE MEDICINE, WILEY-BLACKWELL, Univ Melbourne, Univ Coll, Parkville, AUSTRALIA, Vol. 17, pp. 185 - 185, presented at 9th Biennial Meeting of the Australasian-Gene-and-Cell-Therapy-Society (AGCTS), Univ Melbourne, Univ Coll, Parkville, AUSTRALIA, 29 April 2015 - 01 May 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000362592700020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2015
Conference Papers
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Suzuki K; Swaminathan S; Hood C; Cooper DA; Watanebe T; Kelleher AD, 2011, 'SEQUENCE SPECIFIC INDUCTION OF HIV-1 TRANSCRIPTIONAL GENE SILENCING TARGETING NF-kappa B SEQUENCES BY SIRNA WITHOUT ANY OFF-TARGET EFFECTS OF OTHER NF-kappa B DRIVEN GENES', in JOURNAL OF GENE MEDICINE, WILEY-BLACKWELL, Univ Melbourne, Bio21 Inst, Parkville, AUSTRALIA, pp. 425 - 425, presented at 7th Biennial Meeting of the Australasian-Gene-Therapy-Society, Univ Melbourne, Bio21 Inst, Parkville, AUSTRALIA, 04 May 2011 - 06 May 2011, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000297950900031&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2011

NHMRC Project Grant APP1128012.

HIV-1, gene therapy approaches