Annemiek Beverdam

Senior Lecturer

Dr. Annemiek Beverdam is a developmental geneticist with special interest in epidermal development and regeneration in the mouse, and in the genetic basis of human regenerative skin disease. She obtained her PhD in the lab of Dr Frits Meijlink at the prestigious Hubrecht Institute in The Netherlands. Subsequently, she performed her postdoctoral research in the labs of Dr Giovanni Levi in Italy, Professor Peter Koopman at the IMB in Brisbane, and Professor Brian Key at UQ. Currently, she is Lecturer in Anatomy and Head of the Developmental and Regenerative Dermatology Laboratory at the University of New South Wales. The primary research focus of her lab is the genetic and molecular context in which Yes-associated protein (YAP) functions to control normal epidermal homeostasis, how these processes go awry in regenerative skin diseases such as skin cancer and eczema, and to identify avenues to cure these disorders. Her research is part of a larger, long-term and ambitious goal to identify key genes linking stem cell biology to organ size and growth and is currently funded by the NHMRC.

 

Link to Laboratory page: https://research.unsw.edu.au/projects/dr-annemiek-beverdam

 

Group members:

Ms Anne-Marie Mooney, BSc Hons. Research Assistant.

Mr Bassem Akladios, PhD student, University International Postgraduate Award (UIPA) 

Ms Veronica Mendoza, PhD student, FINCyT scholarship (Peru) and TFS scholarship (UNSW)

Ms Lakshini Ranganathan, BHons student

Ms Yvonne Gathier, Research Intern from University of Groningen, The Netherlands

publications

Journal articles
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Mendoza-Reinoso V; Beverdam A, 2018, 'Epidermal YAP Activity Drives Canonical WNT16/β-catenin Signaling to Promote Keratinocyte Proliferation in vitro and in the Murine Skin', Stem Cell Research, vol. 29, pp. 15 - 23, http://dx.doi.org/10.1016/j.scr.2018.03.005
2018
Corley S; Mendoza-Reinoso V; Giles N; Singer ES; Common JE; Wilkins M; Beverdam A, 2018, 'Plau and Tgfbr3 are YAP-regulated genes that promote keratinocyte proliferation', Cell Death and Disease, vol. 9, pp. 1106, http://dx.doi.org/10.1038/s41419-018-1141-5
2018
Corley S; MacKenzie K; Beverdam A; Roddam LF; Wilkins , 2017, 'Differentially expressed genes from RNA-Seq and functional enrichment results are affected by the choice of single-end versus paired-end reads and stranded versus non-stranded protocols.', BMC Genomics, vol. 18, http://dx.doi.org/10.1186/s12864-017-3797-0
2017
Mendoza-Reinoso V; Corley S; Wilkins M; Beverdam A, 2017, 'Yap regulates wnt16 expression to activate the canonical wnt pathway in keratinocyte proliferation', MECHANISMS OF DEVELOPMENT, vol. 145, pp. S50 - S50, http://dx.doi.org/10.1016/j.mod.2017.04.092
2017
Akladios B; Mendoza-Reinoso V; Cain JE; Wang T; Lambie DL; Watkins DN; Beverdam A, 2017, 'Positive Regulatory Interactions between YAP and Hedgehog Signalling in Skin Homeostasis and BCC Development in Mouse Skin in vivo', PLoS One, vol. 12, pp. e0183178, http://dx.doi.org/10.1371/journal.pone.0183178
2017
Liang H; Akladios B; Canales CP; Francis R; Hardeman EH; Beverdam A, 2016, 'CUBIC protocol visualizes protein expression at single cell resolution in whole mount skin preparations', Journal of Visualized Experiments, vol. 2016, http://dx.doi.org/10.3791/54401
2016
Akladios B; Mendoza-Reinoso V; Samuel MS; Hardeman EC; Khosrotehrani K; Key B; Beverdam A, 2016, 'Epidermal YAP2-5SA-ΔC Drives β-Catenin Activation to Promote Keratinocyte Proliferation in the Mouse Skin in vivo', Journal of Investigative Dermatology, vol. 137, pp. 716 - 726, http://dx.doi.org/10.1016/j.jid.2016.10.029
2016
Corley SM; Canales CP; Carmona-Mora P; Mendoza-Reinosa V; Beverdam A; Hardeman EC; Wilkins MR; Palmer SJ, 2016, 'RNA-Seq analysis of Gtf2ird1 knockout epidermal tissue provides potential insights into molecular mechanisms underpinning Williams-Beuren syndrome', BMC Genomics, vol. 17, http://dx.doi.org/10.1186/s12864-016-2801-4
2016
James G; Key B; Beverdam A, 2014, 'The E3 ubiquitin ligase Mycbp2 genetically interacts with Robo2 to modulate axon guidance in the mouse olfactory system', Brain Structure and Function, vol. 219, pp. 861 - 874, http://dx.doi.org/10.1007/s00429-013-0540-8
2014
Beverdam A; Claxton C; Zhang X; James G; Harvey KF; Key B, 2013, 'Yap controls stem/progenitor cell proliferation in the mouse postnatal epidermis', Journal of Investigative Dermatology, vol. 133, pp. 1497 - 1505, http://dx.doi.org/10.1038/jid.2012.430
2013
James G; Foster SR; Key B; Beverdam A, 2013, 'The Expression Pattern of EVA1C, a Novel Slit Receptor, Is Consistent with an Axon Guidance Role in the Mouse Nervous System', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0074115
2013
James G; Key B; Beverdam A, 2013, 'The E3 ubiquitin ligase Mycbp2 genetically interacts with Robo2 to modulate axon guidance in the mouse olfactory system', Brain Structure and Function, pp. 1 - 14, http://dx.doi.org/10.1007/s00429-013-0540-8
2013
Beverdam A; Svingen T; Bagheri-Fam S; McClive P; Sinclair AH; Harley VR; Koopman P, 2010, 'Protein tyrosine kinase 2 Beta (PTK2B), but not focal adhesion kinase (FAK), is expressed in a sexually dimorphic pattern in developing mouse gonads', Developmental Dynamics, vol. 239, pp. 2735 - 2741, http://dx.doi.org/10.1002/dvdy.22396
2010
Beverdam A; Svingen T; Bagheri-Fam S; Bernard P; McGlive P; Robson M; Khojasteh MB; Salehi M; Sinclair AH; Harley VR; Koopman P, 2009, 'Sox9-dependent expression of Gstm6 in Sertoli cells during testis development in mice', Reproduction, vol. 137, pp. 481 - 486, http://dx.doi.org/10.1530/REP-08-0336
2009
Little MH; Brennan J; Georgas K; Davies JA; Davidson DR; Baldock RA; Beverdam A; Bertram JF; Capel B; Chiu HS; Clements D; Cullen-McEwen L; Fleming J; Gilbert T; Herzlinger D; Houghton D; Kaufman MH; Kleymenova E; Koopman PA; Lewis AG; McMahon AP; Mendelsohn CL; Mitchell EK; Rumballe BA; Sweeney DE; Valerius MT; Yamada G; Yang Y; Yu J, 2007, 'A high-resolution anatomical ontology of the developing murine genitourinary tract', Gene Expression Patterns, vol. 7, pp. 680 - 699, http://dx.doi.org/10.1016/j.modgep.2007.03.002
2007
Little MH; Brennan J; Georgas K; Davies JA; Davidson DR; Baldock RA; Beverdam A; Bertram JF; Capel B; Chiu HS; Clements D; Cullen-McEwen L; Fleming J; Gilbert T; Herzlinger D; Houghton D; Kaufman MH; Kleymenova E; Koopman PA; Lewis AG; McMahon AP; Mendelsohn CL; Mitchell EK; Rumballe BA; Sweeney DE; Valerius MT; Yamada G; Yang Y; Yu J, 2007, 'Corrigendum to "A high-resolution anatomical ontology of the developing murine genitourinary tract" [Gene Expression Patterns 7 (2007) 680-699] (DOI:10.1016/j.modgep.2007.03.002)', Gene Expression Patterns, vol. 8, pp. 47 - 50, http://dx.doi.org/10.1016/j.modgep.2007.07.003
2007
Svingen T; Beverdam A; Verma P; Wilhelm D; Koopman P, 2007, 'Aard is specifically up-regulated in Sertoli cells during mouse testis differentiation', International Journal of Developmental Biology, vol. 51, pp. 255 - 258, http://dx.doi.org/10.1387/ijdb.062219ts
2007
Svingen T; Beverdam A; Bernard P; McClive P; Harley VR; Sinclair AH; Koopman P, 2007, 'Sex-specific expression of a novel gene Tmem184a during mouse testis differentiation', Reproduction, vol. 133, pp. 983 - 989, http://dx.doi.org/10.1530/REP-06-0379
2007
Levi G; Mantero S; Barbieri O; Cantatore D; Paleari L; Beverdam A; Genova F; Robert B; Merlo GR, 2006, 'Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation', Mechanisms of Development, vol. 123, pp. 3 - 16, http://dx.doi.org/10.1016/j.mod.2005.10.007
2006
Beverdam A; Koopman P, 2006, 'Expression profiling of purified mouse gonadal somatic cells during the critical time window of sex determination reveals novel candidate genes for human sexual dysgenesis syndromes', Human Molecular Genetics, vol. 15, pp. 417 - 431, http://dx.doi.org/10.1093/hmg/ddi463
2006
Loffler KA; Combes AN; Wilhelm D; Beverdam A; Bowles J; Koopman P, 2005, 'Pisrt1, a gene implicated in XX sex reversal, is expressed in gonads of both sexes during mouse development', Molecular Genetics and Metabolism, vol. 86, pp. 286 - 292, http://dx.doi.org/10.1016/j.ymgme.2005.06.013
2005
Kuijper S; Beverdam A; Kroon C; Brouwer A; Candille S; Barsh G; Meijlink F, 2005, 'Genetics of shoulder girdle formation: Roles of Tbx15 and aristaless-like genes', Development, vol. 132, pp. 1601 - 1610, http://dx.doi.org/10.1242/dev.01735
2005
Wilhelm D; Martinson F; Bradford S; Wilson MJ; Combes AN; Beverdam A; Bowles J; Mizusaki H; Koopman P, 2005, 'Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination', Developmental Biology, vol. 287, pp. 111 - 124, http://dx.doi.org/10.1016/j.ydbio.2005.08.039
2005
Beverdam A; Wilhelm D; Koopman P, 2003, 'Molecular characterization of three gonad cell lines', Cytogenetic and Genome Research, vol. 101, pp. 242 - 249, http://dx.doi.org/10.1159/000074344
2003
Merlo GR; Beverdam A; Levi G, 2003, 'Dlx genes in craniofacial and limb morphogenesis">Dlx genes in craniofacial and limb morphogenesis', Advances in Developmental Biology and Biochemistry, vol. 13, pp. 107 - 132, http://dx.doi.org/10.1016/S1569-1799(03)13004-3
2003
Beverdam A; Merlo GR; Paleari L; Mantero S; Genova F; Barbieri O; Janvier P; Levi G, 2002, 'Jaw transformation with gain of symmetry after Dlx5/Dlx6 inactivation: Mirror of the past?', Genesis, vol. 34, pp. 221 - 227, http://dx.doi.org/10.1002/gene.10156
2002
Merlo GR; Paleari L; Mantero S; Genova F; Beverdam A; Palmisano GL; Barbieri O; Levi G, 2002, 'Mouse model of split hand/foot malformation type I', Genesis, vol. 33, pp. 97 - 101, http://dx.doi.org/10.1002/gene.10098
2002
Beverdam A; Brouwer A; Reijnen M; Korving J; Meijlink F, 2001, 'Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice', Development, vol. 128, pp. 3975 - 3986
2001
Beverdam A; Meijlink F, 2001, 'Expression patterns of group-I aristaless-related genes during craniofacial and limb development', Mechanisms of Development, vol. 107, pp. 163 - 167, http://dx.doi.org/10.1016/S0925-4773(01)00450-6
2001
Meijlink F; Beverdam A; Brouwer A; Oosterveen TC; Ten Berge D, 1999, 'Vertebrate aristaless-related genes', International Journal of Developmental Biology, vol. 43, pp. 651 - 663
1999
Conference Papers
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Beverdam A; Koopman P, 2005, 'Identification of novel genes involved in male and female sex determination and early gonad development', in MECHANISMS OF DEVELOPMENT, ELSEVIER SCIENCE BV, pp. S69 - S69, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000207524100256&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2005
Bradford S; Wilhelm D; Jackson A; Beverdam A; Koopman P, 2005, 'A search for downstream targets of SRY', in MECHANISMS OF DEVELOPMENT, ELSEVIER SCIENCE BV, pp. S50 - S51, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000207524100184&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2005
Merlo G; Mantero S; Maggioni M; Beverdam A; Paleari L; Genova F; Levi G, 2003, 'Homeotic transformation of first branchial arch and cleft limbs in Dlx5/Dlx6 double mutant mice.', in DEVELOPMENTAL BIOLOGY, ACADEMIC PRESS INC ELSEVIER SCIENCE, BOSTON, MASSACHUSETTS, pp. 566 - 566, presented at 62nd Annual Meeting of the Society-for-Development-Biology, BOSTON, MASSACHUSETTS, 30 July 2003 - 02 August 2003, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000184373300499&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2003