Adam Hill

Senior Research Fellow

publications

Journal articles
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Li Z; Mirams GR; Yoshinaga T; Ridder BJ; Han X; Chen JE; Stockbridge NL; Wisialowski TA; Damiano B; Severi S; Morissette P; Kowey PR; Holbrook M; Smith G; Rasmusson RL; Liu M; Song Z; Qu Z; Leishman DJ; Steidl-Nichols J; Rodriguez B; Bueno-Orovio A; Zhou X; Passini E; Edwards AG; Morotti S; Ni H; Grandi E; Clancy CE; Vandenberg J; Hill A; Nakamura M; Singer T; Polonchuk L; Greiter-Wilke A; Wang K; Nave S; Fullerton A; Sobie EA; Paci M; Musuamba Tshinanu F; Strauss DG, 2020, 'General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy', Clinical Pharmacology and Therapeutics, vol. 107, pp. 102 - 111, http://dx.doi.org/10.1002/cpt.1647
2020
Ng CA; Perry MD; Liang W; Smith NJ; Foo B; Shrier A; Lukacs GL; Hill AP; Vandenberg JI, 2020, 'High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants', Heart Rhythm, vol. 17, pp. 492 - 500, http://dx.doi.org/10.1016/j.hrthm.2019.09.020
2020
Lee W; Windley MJ; Perry MD; Vandenberg JI; Hill AP, 2019, 'Protocol-dependent differences in IC50 values measured in human ether-á-go-go–related gene assays occur in a predictable way and can be used to quantify state preference of drug binding', Molecular Pharmacology, vol. 95, pp. 537 - 550, http://dx.doi.org/10.1124/mol.118.115220
2019
Hill AP, 2019, 'Introduction to the Australian Society for Biophysics', Biophysical Reviews, vol. 11, pp. 253 - 254, http://dx.doi.org/10.1007/s12551-019-00519-0
2019
Holliday M; Ross SB; Lim S; Mangala M; Hill A; Szappanos HC; Hool L; Semsarian C, 2018, 'Development of induced pluripotent stem cells from a patient with hypertrophic cardiomyopathy who carries the pathogenic myosin heavy chain 7 mutation p.Arg403Gln', Stem Cell Research, vol. 33, pp. 269 - 273, http://dx.doi.org/10.1016/j.scr.2018.11.011
2018
Beattie KA; Hill AP; Bardenet R; Cui Y; Vandenberg JI; Gavaghan DJ; de Boer TP; Mirams GR, 2018, 'Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics', Journal of Physiology, vol. 596, pp. 1813 - 1828, http://dx.doi.org/10.1113/JP275733
2018
Windley MJ; Lee W; Vandenberg JI; Hill AP, 2018, 'The temperature dependence of kinetics associated with drug block of hERG channels is compound-specific and an important factor for proarrhythmic risk prediction', Molecular Pharmacology, vol. 94, pp. 760 - 769, http://dx.doi.org/10.1124/mol.117.111534
2018
Munawar S; Windley MJ; Tse EG; Todd MH; Hill AP; Vandenberg JI; Jabeen I, 2018, 'Experimentally validated pharmacoinformatics approach to predict hERG inhibition potential of new chemical entities', Frontiers in Pharmacology, vol. 9, http://dx.doi.org/10.3389/fphar.2018.01035
2018
Windley MJ; Abi-Gerges N; Fermini B; Hancox JC; Vandenberg JI; Hill AP, 2017, 'Measuring kinetics and potency of hERG block for CiPA', Journal of Pharmacological and Toxicological Methods, vol. 87, pp. 99 - 107, http://dx.doi.org/10.1016/j.vascn.2017.02.017
2017
Beattie K; Hill A; Bardenet R; Cui Y; Vandenberg J; Gavaghan D; de Boer T; Mirams G, 2017, 'Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics', , http://dx.doi.org/10.1101/100677
2017
Bavi N; Bavi O; Vossoughi M; Naghdabadi R; Hill AP; Martinac B; Jamali Y, 2017, 'Nanomechanical properties of MscL α helices: A steered molecular dynamics study', Channels, vol. 11, pp. 209 - 223, http://dx.doi.org/10.1080/19336950.2016.1249077
2017
Nikolova-Krstevski V; Wagner S; Yu ZY; Cox CD; Cvetkovska J; Hill AP; Huttner IG; Benson V; Werdich AA; MacRae C; Feneley MP; Friedrich O; Martinac B; Fatkin D, 2017, 'Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk', JACC: Basic to Translational Science, vol. 2, pp. 575 - 590, http://dx.doi.org/10.1016/j.jacbts.2017.05.006
2017
Hill AP, 2017, 'Boosting the reserves: additive regulation of cardiac repolarisation', Journal of Physiology, vol. 595, pp. 2269 - 2270, http://dx.doi.org/10.1113/JP273940
2017
Bavi N; Martinac AD; Cortes DM; Bavi O; Ridone P; Nomura T; Hill AP; Martinac B; Perozo E, 2017, 'Structural Dynamics of the MscL C-terminal Domain', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-17396-w
2017
Lee W; Windley MJ; Vandenberg JI; Hill AP, 2017, 'In vitro and in silico risk assessment in acquired long QT syndrome: The devil is in the details', Frontiers in Physiology, vol. 8, http://dx.doi.org/10.3389/fphys.2017.00934
2017
Vandenberg JI; Perry MD; Hill AP, 2017, 'Recent advances in understanding and prevention of sudden cardiac death', F1000Research, vol. 6, http://dx.doi.org/10.12688/f1000research.11855.1
2017
Hill AP; Perry MD; Abi-Gerges N; Couderc JP; Fermini B; Hancox JC; Knollmann BC; Mirams GR; Skinner J; Zareba W; Vandenberg JI, 2016, 'Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century', Journal of Physiology, vol. 594, pp. 6893 - 6908, http://dx.doi.org/10.1113/JP272015
2016
Mann SA; Imtiaz M; Winbo A; Rydberg A; Perry MD; Couderc JP; Polonsky B; McNitt S; Zareba W; Hill AP; Vandenberg JI, 2016, 'Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes', Journal of Molecular and Cellular Cardiology, vol. 100, pp. 25 - 34, http://dx.doi.org/10.1016/j.yjmcc.2016.09.011
2016
Bavi N; Cortes DM; Cox CD; Rohde PR; Liu W; Deitmer JW; Bavi O; Strop P; Hill AP; Rees D; Corry B; Perozo E; Martinac B, 2016, 'The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels', Nature Communications, vol. 7, http://dx.doi.org/10.1038/ncomms11984
2016
Immanuel SA; Sadrieh A; Baumert M; Couderc JP; Zareba W; Hill AP; Vandenberg JI, 2016, 'T-wave morphology can distinguish healthy controls from LQTS patients', Physiological Measurement, vol. 37, pp. 1456 - 1473, http://dx.doi.org/10.1088/0967-3334/37/9/1456
2016
Lee W; Mann SA; Windley MJ; Imtiaz MS; Vandenberg JI; Hill AP, 2016, 'In silico assessment of kinetics and state dependent binding properties of drugs causing acquired LQTS', Progress in Biophysics and Molecular Biology, vol. 120, pp. 89 - 99, http://dx.doi.org/10.1016/j.pbiomolbio.2015.12.005
2016
Windley MJ; Mann SA; Vandenberg JI; Hill AP, 2016, 'Temperature effects on kinetics of KV11.1 drug block have important consequences for in silico proarrhythmic risk prediction', Molecular Pharmacology, vol. 90, pp. 1 - 11, http://dx.doi.org/10.1124/mol.115.103127
2016
Perry MD; Ng CA; Phan K; David E; Steer K; Hunter MJ; Mann SA; Imtiaz M; Hill AP; Ke Y; Vandenberg JI, 2016, 'Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations', Journal of Physiology, vol. 594, pp. 4031 - 4049, http://dx.doi.org/10.1113/JP271805
2016
Hodkinson EC; Neijts M; Sadrieh A; Imtiaz MS; Baumert M; Subbiah RN; Hayward CS; Boomsma D; Willemsen G; Vandenberg JI; Hill AP; De Geus E, 2016, 'Heritability of ECG biomarkers in the Netherlands twin registry measured from Holter ECGs', Frontiers in Physiology, vol. 7, http://dx.doi.org/10.3389/fphys.2016.00154
2016
Perry MD; Ng CA; Mann SA; Sadrieh A; Imtiaz M; Hill AP; Vandenberg JI, 2015, 'Getting to the heart of hERG K+ channel gating', Journal of Physiology, vol. 593, pp. 2575 - 2585, http://dx.doi.org/10.1113/JP270095
2015
Chaudhuri R; Sadrieh A; Hoffman NJ; Parker BL; Humphrey SJ; Stöckli J; Hill AP; James DE; Yang JYH, 2015, 'PhosphOrtholog: A web-based tool for cross-species mapping of orthologous protein post-translational modifications', BMC Genomics, vol. 16, http://dx.doi.org/10.1186/s12864-015-1820-x
2015
Ng CA; Phan K; Hill AP; Vandenberg JI; Perry MD, 2014, 'Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels', Journal of Biological Chemistry, vol. 289, pp. 25822 - 25832, http://dx.doi.org/10.1074/jbc.M114.558379
2014
Sadrieh A; Domanski L; Pitt-Francis J; Mann SA; Hodkinson EC; Ng CA; Perry MD; Taylor JA; Gavaghan D; Subbiah RN; Vandenberg JI; Hill AP, 2014, 'Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2', Nature Communications, vol. 5, http://dx.doi.org/10.1038/ncomms6069
2014
Hill AP; Perrin MJ; Heide J; Campbell TJ; Mann SA; Vandenberg JI, 2014, 'Kinetics of drug interaction with the Kv11.1 potassium channel', Molecular Pharmacology, vol. 85, pp. 769 - 776, http://dx.doi.org/10.1124/mol.114.091835
2014
Hodkinson EC; Hill AP; Vandenberg JI, 2014, 'The Romano-Ward syndrome--1964-2014: 50 years of progress.', Irish medical journal, vol. 107, pp. 122 - 124
2014
Hodkinson EC; Hill AP; Vandenberg JI, 2014, 'The romano-ward syndrome 1964 2014: 50 years of progress', Irish Medical Journal, vol. 107
2014
Ke Y; Ng CA; Hunter MJ; Mann SA; Heide J; Hill AP; Vandenberg JI, 2013, 'Trafficking defects in PAS domain mutant Kv11.1 channels: Roles of reduced domain stability and altered domain-domain interactions', Biochemical Journal, vol. 454, pp. 69 - 77, http://dx.doi.org/10.1042/BJ20130328
2013
Sadrieh A; Mann SA; Subbiah RN; Domanski L; Taylor JA; Vandenberg JI; Hill AP, 2013, 'Quantifying the origins of population variability in cardiac electrical activity through sensitivity analysis of the electrocardiogram', Journal of Physiology, vol. 591, pp. 4207 - 4222, http://dx.doi.org/10.1113/jphysiol.2013.251710
2013
Ng CA; Ke Y; Perry MD; Tan PS; Hill AP; Vandenberg JI, 2013, 'C-Terminal β9-Strand of the Cyclic Nucleotide-Binding Homology Domain Stabilizes Activated States of Kv11.1 Channels', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0077032
2013
Tan PS; Perry MD; Ng C; Vandenberg JI; Hill A, 2012, 'Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels', Journal of General Physiology, vol. 140, pp. 293 - 306, http://dx.doi.org/10.1085/jgp.201110761
2012
Yu Y; Hill AP; McCormick DA, 2012, 'Warm body temperature facilitates energy efficient cortical action potentials', PLoS Computational Biology, vol. 8, http://dx.doi.org/10.1371/journal.pcbi.1002456
2012
Pan D; Hill AP; Kashou A; Wilson KA; Tan-Wilson A, 2011, 'Electrophoretic transfer protein zymography', Analytical Biochemistry, vol. 411, pp. 277 - 283, http://dx.doi.org/10.1016/j.ab.2011.01.015
2011
Wang DT; Hill A; Mann SA; Tan P; Vandenberg JI, 2010, 'Mapping the sequence of conformational changes underlying selectivity filter gating in the K(v)11.1 potassium channel', Nature Structural and Molecular Biology, vol. 18, pp. 35 - 41, http://dx.doi.org/10.1038/nsmb.1966
2010
Clarke O; Caputo A; Hill A; Vandenberg JI; Smith B; Gulbis J, 2010, 'Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels', Cell, vol. 141, pp. 1018 - 1029, http://dx.doi.org/10.1016/j.cell.2010.05.003
2010
Zhao JT; Hill A; Varghese A; Cooper A; Swan H; Laitinen-Forsblom P; Rees M; Skinner J; Campbell TJ; Vandenberg JI, 2009, 'Not all hERG pore domain mutations have a severe phenotype: G584S has an inactivation gating defect with mild phenotype compared to G572S, which has a dominant negative trafficking defect and a severe phenotype', Journal of Cardiovascular Electrophysiology, vol. 20, pp. 923 - 930, http://dx.doi.org/10.1111/j.1540-8167.2009.01468.x
2009
Perrin MJ; Subbiah RN; Vandenberg JI; Hill A, 2008, 'Human ether-a-go-go related gene (hERG) K+ channels: Function and dysfunction', Progress in Biophysics and Molecular Biology, vol. 98, pp. 137 - 148, http://dx.doi.org/10.1016/j.pbiomolbio.2008.10.006
2008
Hill A; Sunde M; Vandenberg JI, 2007, 'Mechanisms of block of the hERG K+ channel by the scorpion toxin CnErg1', Biophysical Journal, pp. 124A - 124A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000243972400570&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2007
Hill A; Campbell TJ; Bansal PS; Kuchel PW; Vandenberg JI, 2007, 'The S631A mutation causes a mechanistic switch in the block of hERG channels by CnErgl', Biophysical Journal, vol. 93, pp. 32 - 34, http://dx.doi.org/10.1529/biophysj.107.114561
2007
Hill A; Sunde M; Campbell TJ; Vandenberg JI, 2007, 'Mechanism of block of the hERG K+ channel by the scorpion toxin CnErg1', Biophysical Journal, vol. 92, pp. 3915 - 3929, http://dx.doi.org/10.1529/biophysj.106.101956
2007
Clarke CE; Hill A; Kondo M; Subbiah RN; Campbell TJ; Vandenberg JI, 2006, 'Effect of S5P alpha-helix charge mutants on inactivation of hERG K+ channels', The Journal of Physiology, vol. 573, pp. 291 - 304, http://dx.doi.org/10.1113/jphysiol.2006.108332
2006
Hill AP; Kingston O; Sitsapesan R, 2004, 'Functional regulation of the cardiac ryanodine receptor by suramin and calmodulin involves multiple binding sites', Molecular Pharmacology, vol. 65, pp. 1258 - 1268, http://dx.doi.org/10.1124/mol.65.5.1258
2004
Hill AP; Sitsapesan R, 2002, 'DIDS modifies the conductance, gating, and inactivation mechanisms of the cardiac ryanodine receptor', Biophysical Journal, vol. 82, pp. 3037 - 3047, http://dx.doi.org/10.1016/S0006-3495(02)75644-0
2002
Carriero D; Aberman J; Lin SY; Hill A; Makriyannis A; Salamone JD, 1998, 'A detailed characterization of the effects of four cannabinoid agonists on operant lever pressing', Psychopharmacology, vol. 137, pp. 147 - 156, http://dx.doi.org/10.1007/s002130050604
1998
Pertwee R; Griffin G; Fernando S; Li X; Hill A; Makriyannis A, 1995, 'AM630, a competitive cannabinoid receptor antagonist', Life Sciences, vol. 56, pp. 1949 - 1955, http://dx.doi.org/10.1016/0024-3205(95)00175-6
1995
Conference Abstracts
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Gulbis JM; Miller DM; Black K; Hill AP; Laver D, 2018, 'Can K+ be Conducted through a Narrow Pore? Investigating the role of Conformational Change in Gating Kir Channels', in BIOPHYSICAL JOURNAL, CELL PRESS, San Francisco, CA, Vol. 114, pp. 35A - 35A, presented at 62nd Annual Meeting of the Biophysical-Society, San Francisco, CA, 17 February 2018 - 21 February 2018, http://dx.doi.org/10.1016/j.bpj.2017.11.249
2018
Beattie KA; Bardenet R; Louttit JB; Vandenberg JI; Hill AP; Gavaghan DJ; de Boer TP; Mirams GR, 2017, 'Mathematical Modelling of hERG Channel Kinetics Using Sinusoidal Voltage Protocols', in JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, ELSEVIER SCIENCE INC, Vol. 88, pp. 195 - 196, http://dx.doi.org/10.1016/j.vascn.2017.09.089
2017
Bavi N; Cox CD; Rohde PR; Hill AP; Corry B; Martinac B, 2016, 'The N-Terminal Helix Acts as a Dynamic Membrane Coupler in the Gating Cycle of the Mechanosensitive Channel MscL', in BIOPHYSICAL JOURNAL, CELL PRESS, Los Angeles, CA, Vol. 110, pp. 116A - 116A, presented at 60th Annual Meeting of the Biophysical-Society, Los Angeles, CA, 27 February 2016 - 02 March 2016, http://dx.doi.org/10.1016/j.bpj.2015.11.677
2016
Mann SA; Vandenberg JI; Hill AP, 2016, 'Sudden Infant Death and Modulation of Late Sodium Current by Hypoxia, Investigated in Induced Pluripotent Stem Cells', in BIOPHYSICAL JOURNAL, CELL PRESS, Los Angeles, CA, Vol. 110, pp. 30A - 30A, presented at 60th Annual Meeting of the Biophysical-Society, Los Angeles, CA, 27 February 2016 - 02 March 2016, http://dx.doi.org/10.1016/j.bpj.2015.11.227
2016
Hill AP; Mann SA; Imtiaz MS; Perry MD; Vandenberg JI, 2014, 'Using Clinical Datasets to Optimize Models of Human Ventricular Electrophysiology: Implications for In Silico Drug Screening', in BIOPHYSICAL JOURNAL, CELL PRESS, San Francisco, CA, Vol. 112, pp. 465A - 465A, presented at 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, 15 February 2014 - 19 February 2014, http://dx.doi.org/10.1016/j.bpj.2016.11.2493
2014
El-Ajouz S; Hill AP; Gulbis JM; Vandenberg JI, 2013, 'Understanding the Molecular Gates of KirBac3.1', in BIOPHYSICAL JOURNAL, CELL PRESS, Philadelphia, PA, Vol. 104, pp. 128A - 128A, presented at 57th Annual Meeting of the Biophysical-Society, Philadelphia, PA, 02 February 2013 - 06 February 2013, http://dx.doi.org/10.1016/j.bpj.2012.11.737
2013
Szekely D; Dokos S; Vandenberg JI; Hill AP, 2010, 'An Improved Curvilinear Gradient Method for Parameter Estimation in Complex Model Systems: Application to Gating of A Cardiac Ion Channel', in BIOPHYSICAL JOURNAL, CELL PRESS, Vol. 98, pp. 140A - 141A, http://dx.doi.org/10.1016/j.bpj.2009.12.758
2010
Other
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Vandenberg JI; Hill AP, 2016, An 'alternans' way to quantify arrhythmogenic substrates, http://dx.doi.org/10.1113/JP271838
2016
Vandenberg JI; Hill AP; Campbell TJ; Clarke CE, 2006, Reply from Jamie I. Vandenberg, Adam P. Hill, Terence J. Campbell, Catherine E. Clarke [2], http://dx.doi.org/10.1113/jphysiol.2006.577102
2006
Conference Papers
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Sadrieh A; Charissis S; Hill AP, 2013, 'An on-chip heterogeneous implementation of a general sparse linear solver', in Proceedings - IEEE 27th International Parallel and Distributed Processing Symposium Workshops and PhD Forum, IPDPSW 2013, pp. 54 - 63, http://dx.doi.org/10.1109/IPDPSW.2013.51
2013
Tan PS; Perry M; Chai AN; Vandenberg JI; Hill AP, 2012, 'Bimodal Regulation of hERG Gating by the N-Terminal Tail Revealed by Voltage Clamp Fluorometry', in BIOPHYSICAL JOURNAL, CELL PRESS, San Diego, CA, pp. 328A - 328A, presented at 56th Annual Meeting of the Biophysical-Society, San Diego, CA, 25 February 2012 - 29 February 2012, http://dx.doi.org/10.1016/j.bpj.2011.11.1800
2012