Events

Dr Leo James: Trim-Away: Targeted degradation of pathogens and proteins by the cytosolic antibody receptor TRIM21

Event date: 
18 February 2019 - 2:00pm
Location: 
Berg Family Foundation Seminar Room, Level 6 Wallace Wurth Building, Kensington Campus, UNSW Sydney
Open to: 
All
Event Type: 
Seminar
Booking deadline: 

Dr Leo James received his Ph.D. from Cambridge University in 2000 and post-doc'ed with Prof Dan Tawfik and Sir Greg Winter, on antibody structure, function and evolution. In 2007, Leo established a lab at the LMB in Cambridge studying host-pathogen interactions using a broad range of in vitro and in vivo techniques.

In 2010, Leo discovered TRIM21, the most conserved and highest affinity antibody receptor in mammals and uniquely cytosolically expressed. Since then, his lab has shown that TRIM21 prevents infection by intercepting viruses, bacteria and pathogenic proteins inside the cell and targeting them for rapid degradation. This work has also led to the development of 'TrimAway', a technique which exploits TRIM21 for the rapid and specific degradation of cellular proteins.

Leo also investigates HIV post-fusion biology; recent work includes identifying the HIV capsid interface used to recruit import cofactors and dynamic pores in the capsid that are essential for HIV infection.

Contact for inquiries: 
David Jacques d.jacques@unsw.edu.au
Image - Dr Leo James: Trim-Away: Targeted degradation of pathogens and proteins by the cytosolic antibody receptor TRIM21

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20 March 2019

Room 305, Level 3, Samuels Building, UNSW Upper Campus, Kensington

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